A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 12, Issue 3, 1995, Pages 413-420

  Amidon, Gordon L ^a   Lennernäs, Hans ^b   Shah, Vinod P ^c   Crison, John R ^d  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UPPSALA UNIVERSITY   (Sweden)

^c Division of Cellular and Gene Therapies   (United States)

^d TSRL INC   (United States)

Author keywords

bioavailability; drug absorption; in vitro in vivo correlation; intestinal permeability; mathematical modeling

Indexed keywords

CARBAMAZEPINE; CHLOROTHIAZIDE; CIMETIDINE; DIGOXIN; GLIBENCLAMIDE; GRISEOFULVIN; PIROXICAM;

ARTICLE; DISSOLUTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLASSIFICATION; DRUG SOLUBILITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; MATHEMATICAL MODEL; PRIORITY JOURNAL; THEORY;

NON-PROGRAMMATIC;

BIOLOGICAL AVAILABILITY; CIMETIDINE; GASTRIC EMPTYING; IN VITRO; JEJUNUM; MATHEMATICS; MODELS, THEORETICAL; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; PIROXICAM; SOLUBILITY; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028948839     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1016212804288     Document Type: Article

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