-
2
-
-
0027535559
-
Toward an understanding of the molecular mechanisms of physiological cell death
-
edn 2
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 786-789
-
-
Vaux1
-
3
-
-
0025899138
-
Programmed cell death: apoptosis and oncogenesis
-
(1991)
Cell
, vol.65
, pp. 1097-1098
-
-
Williams1
-
4
-
-
0027532285
-
Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene
-
of special interest, These authors demonstrated that Sindbis virus, a type of alphavirus, causes cytopathic effect in non-neuronal cells by inducing apoptosis. Expression of the cellular bcl-2 oncogene can prevent Sindbis virus induced apoptosis and transform an acute lytic infection into a persistent infection.
-
(1993)
Nature
, vol.361
, pp. 739-742
-
-
Levine1
Huang2
Isaacs3
Reed4
Griffin5
Hardwick6
-
5
-
-
0027325778
-
Biochemical events in naturally occuring forms of cell death
-
(1993)
FEBS Lett
, vol.328
, pp. 1-5
-
-
Fesus1
-
6
-
-
0027146334
-
Death defying acts: a meeting review on apoptosis
-
(1993)
Genes Dev
, vol.7
, pp. 2277-2284
-
-
White1
-
8
-
-
0028278094
-
Apoptosis: a mechanism of cell killing by influenza A and B viruses
-
of special interest, This paper and [7•] present evidence that influenza A and B viruses induce apoptosis in cultured cells, and this virally induced apoptosis correlates with the development of the cytopathic effects during viral infection. Expression of the cellular bcl-2 oncogene can protect infected cells from the apoptotic cell death. The authors suggest that apoptosis may be a general mechanism of cell death in hosts infected with influenza viruses.
-
(1994)
J Vrol
, vol.68
, pp. 3667-3673
-
-
Hinshaw1
Olsen2
Dybdahl-Sissoko3
Evans4
-
12
-
-
0027236910
-
Programmed cell death of T lymphocytes during acute viral infection- a mechanism for virus-induced immune deficiency
-
(1993)
J Virol
, vol.67
, pp. 5754-5765
-
-
Razvi1
Welsh2
-
13
-
-
0028349060
-
Murine retrovirus-induced depletion of T cells is mediated through activation4nduced death by apoptosis
-
(1994)
J Virol
, vol.68
, pp. 2735-2740
-
-
Saha1
Yuen2
Wong3
-
19
-
-
0028181091
-
HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by ‘tissue’ transglutaminase expression and prevented by cyclosporin A
-
of special interest, Induction of apoptosis in CD4+ T cells by treatment with HIV gp120 is accompanied by the increased expression of ‘tissue’ transglutaminase, a characterized mediator of apoptosis. CsA, an immunosuppressor which can prevent gp120-induced apoptosis, blocks the activation of transglutaminase. It is suggested that transglutaminase might mediate the apoptotic effects induced by HIV infection.
-
(1994)
FEBS Lett
, vol.339
, pp. 258-264
-
-
Amendola1
Lombardi2
Oliverio3
Colizzi4
Piacentini5
-
20
-
-
0028283577
-
HIV1 induces down-regulation of bcl-2 expression and death by apoptosis of EBV-immortalized B cells: a model for a persistent ‘self-limiting’ HIV-1 infection
-
of special interest, HIV-infected EBV-positive B cells die of apoptosis when they are plated in culture. It is shown in this paper that bcl-2 expression is down-regulated in HIV-infected cells as compared to uninfected cells. This may suggest a possible mechanism by which HIV causes apoptosis in infected cells.
-
(1994)
Virology
, vol.198
, pp. 234-244
-
-
de Rossi1
Ometto2
Roncella3
D'Andrea4
Menin5
Calderazzo6
Rowe7
Ferrarini8
Chieco-Bianchi9
-
21
-
-
23444435250
-
Prevention of vertebrate neuronal death by the crmA gene
-
of outstanding interest, This paper shows that expression of the cowpox virus crmA gene in chicken neuronal cells protects these cells from apoptosis induced by deprivation of nerve growth factor. As the crmA gene product is a specific inhibitor of ICE, a mediator of apoptosis in mammalian fibroblasts, it is suggested that ICE is likely to also participate in neuronal death in vertebrates.
-
(1994)
Science
, vol.263
, pp. 826-828
-
-
Gagliardini1
Fernandez2
Lee3
Drexler4
Rotello5
Fishman6
Yuan7
-
22
-
-
0027449187
-
Induction of apoptosis in fibroblasts by IL-1f~-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
-
of outstanding interest, ICE is a protease that has sequence similarity to the C. elegans ced-3 cell death gene product. Overexpression of either ICE or Ced-3 in mammalian fibroblasts leads to apoptosis which can be blocked by overexpression of the cellular bcl-2 proto-oncogene. The protease activity of ICE is required for its ability to induce apoptosis, as crmA gene product, a specific inhibitor of ICE protease activity encoded by cowpox virus, can block ICE-induced apoptosis.
-
(1993)
Cell
, vol.75
, pp. 653-660
-
-
Miura1
Zhu2
Rotello3
Hartwieg4
Yuan5
-
23
-
-
0028224556
-
Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53
-
of outstanding interest, edn 2, These authors demonstrate that the SV40 large T antigen, when expressed in thymocytes of transgenic mice, can block p53-dependent apoptosis (irradiation-induced apoptosis), but not p53-independent apoptosis (clonal depletion of autoreactive thymocytes). The ability of T antigen to block p53-dependent apoptosis depends apparently on its ability to bind to and inactivate p53—mutants of T antigen that fail to bind to p53 are unable to block irradiation-induced apoptosis.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3979-3983
-
-
McCarthy1
Symonds2
Van Dyke3
-
24
-
-
0028169994
-
p53-dependent apoptosis suppresses tumor growth and progression in vivo
-
of outstanding interest, The authors studied the functions of p53 and SV40 T antigen in brain tumorigenesis using a transgenic mouse model. Expression of a mutant SV40 T antigen, that interacts with pRb but not with p53 leads to slow tumor formation as compared to wild-type T antigen, which causes rapid and aggressive tumor formation. It is suggested that p53 induces apoptosis of the transformed cells, thereby suppressing tumor formation. Wild-type T antigen may block p53-mediated apoptosis by binding to and inactivating p53.
-
(1994)
Cell
, vol.78
, pp. 703-711
-
-
Symonds1
Krall2
Remington3
Saenz-Robles4
Lowe5
Jacks6
Van Dyke7
-
25
-
-
0028334011
-
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implication for tumor suppressor gene function in development
-
of outstanding interest, Using transgenic mouse models, these authors demonstrated that expression, of the human papilloma virus (HPV)-l6 E7 protein alone can induce cell proliferation, inhibit differentiation, and cause apoptosis. The E7-induced apoptosis appears to be mediated by p53, as expression of the HPV-16 E6 protein, a viral oncoprotein that binds to and mediates the degradation of p53, can block the E7-induced apoptosis. Tumors develop only in E6×E7 double transgenic mice, but not in E6 or E7 transgenic mice.
-
(1994)
Genes Dev
, vol.8
, pp. 1285-1299
-
-
Pan1
Griep2
-
26
-
-
0028087776
-
p52, guardian of Rb
-
(1994)
Nature
, vol.371
, pp. 21-22
-
-
White1
-
27
-
-
0021739589
-
Deletion of the gene encoding the adenovirus 5 early region 1111 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA
-
(1984)
J Virol
, vol.52
, pp. 664-671
-
-
Pilder1
Logan2
Shenk3
-
28
-
-
0021684759
-
Mutations in the gene encoding the adenovirus early region 1B 19000-molecularweight tumor antigen cause the degradation of chromosomal DNA
-
(1984)
J Vrol
, vol.52
, pp. 410-419
-
-
White1
Grodzicker2
Stillman3
-
29
-
-
0021752891
-
Cyt gene of adenovirus 2 and 5 is an oncogene for transforming function in early region E1111 and encodes the E111 19,000 molecular-weight polypeptide
-
(1984)
J Vrol
, vol.52
, pp. 793-805
-
-
Takemori1
Cladaras2
Bhat3
Conley4
Wold5
-
32
-
-
0026063253
-
Transcriptional and transforming activities of the adenovirus EIA proteins
-
(1991)
Adv Cancer Res
, vol.57
, pp. 47-85
-
-
Shenk1
Flint2
-
33
-
-
0001424128
-
Adenoviridae, the viruses and their replication
-
B. Fields, P. Howley, D. Knipe, Raven Press, New York, in press
-
(1995)
Virology
-
-
Shenk1
-
34
-
-
0027251720
-
Wild-type pS3 mediates apoptosis by EIA, which is inhibited by E1B
-
of outstanding interest, A temperature-sensitive p53 mutant was used to demonstrate that wild-type p53 is required for ElA-induced apoptosis. Mutant p53 blocks induction of apoptosis by ElA and therefore may cooperate with EIA to transform primary cells. Induction of apoptosis by El A and wild-type p53 can be blocked by ElB 19 kDa or ElB 55 kDa protein.
-
(1993)
Genes Dev
, vol.7
, pp. 546-554
-
-
Debbas1
White2
-
35
-
-
0027262606
-
Stabilization of the pS3 tumor suppressor is induced by adenovirus EIA and accompanies apoptosis
-
of outstanding interest, Expression of adenovirus El A protein stabilizes pS3 in a variety of cell types. Stabilized pS3 is indistinguishable from wild-type pS3 with respect to its nuclear localization and its interaction with a number of cellular and viral proteins.
-
(1993)
Genes Dev
, vol.7
, pp. 535-545
-
-
Lowe1
Ruley2
-
37
-
-
0028299320
-
Induction of apoptosis by adenovirus type 5 EIA in rat cells requires a proliferation block
-
of outstanding interest, The authors demonstrated that the adenovirus El A protein can efficiently induce apoptosis only when cell proliferation is inhibited, either by serum starvation or by cell-cell contacts in confluent cultures, and not when cells are actively growing. Regions of the El A protein essential for induction of apoptosis overlap the regions required for binding to p300 and pRb. The authors suggest that apoptosis may result from conflicting cell growth signals; induction of proliferation by ElA and proliferation block by unfavorable growth conditions.
-
(1994)
Oncogene
, vol.9
, pp. 1187-1193
-
-
Mymryk1
Shire2
Bayley3
-
39
-
-
0028227260
-
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
-
of outstanding interest, Inactivation of pRb by expressing the HPV-16 E7 protein in retinal photoreceptor cells of transgenic mice leads to unchecked cell proliferation and apoptosis. Apoptosis occurs only in the presence of functional p53. In the absence of p53, apoptosis does not occur and tumors develop.
-
(1994)
Genes Dev
, vol.8
, pp. 1300-1310
-
-
Howes1
Ransom2
Papermaster3
Lasudry4
Albert5
Windle6
-
41
-
-
0026526437
-
E2F: a link between the Rb tumor suppressor protein and viral oncoproteins
-
(1992)
Science
, vol.258
, pp. 424-429
-
-
Nevins1
-
42
-
-
0028222124
-
p53 and E2F-1 cooperate to mediate apoptosis
-
of outstanding interest, edn 2, The first demonstration that co-expression of the wild-type pS3 and E2F-1 in mammalian cells results in apoptotic cell death.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3602-3606
-
-
Wu1
Levine2
-
43
-
-
0020079972
-
Adenovirus ElB-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54kd cellular protein
-
(1982)
Cell
, vol.28
, pp. 387-394
-
-
Sarnow1
Ho2
Williams3
Levine4
-
44
-
-
0026560315
-
Inhibition of pS3 transactivation required for transformation by adenovirus early 1 B protein
-
(1992)
Nature
, vol.357
, pp. 82-85
-
-
Yew1
Berk2
-
45
-
-
0028089283
-
Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.
-
of special interest, The El B 55 kDa protein of adenovirus can serve as a transcriptional repressor when it is artificially anchored to a promoter. It is suggested that the interaction of the El B 55 kDa protein with pS3 not only blocks the transcriptional activation activity of pS3, but also serves to bring the viral protein to the promoters that contain p53-responsive elements. The E1B 55 kDa protein may then actively repress transcription.
-
(1994)
Genes & Development
, vol.8
, pp. 190-202
-
-
Yew1
Liu2
Berk3
-
46
-
-
0028575705
-
Relief of p53-mediated transcriptional repression by the adenovirus El B 19 kDa protein or the cellular Bcl-2 protein
-
of outstanding interest, edn 2, This report shows that the adenovirus El B 19 kDa protein and the cellular Bcl-2 protein not only abrogate pS3 transcriptional repression activity, but also cause pS3 to activate promoters that it normally represses. Transcriptional activation by pS3, on the other hand, still occurs in the presence of either protein.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8940-8944
-
-
Shen1
Shenk2
-
48
-
-
0021706440
-
Nuclear envelope localization of an adenovirus tumor antigen maintains the integrity of cellular DNA
-
(1984)
Mol Cell Biol
, vol.4
, pp. 2865-2875
-
-
White1
Blose2
Stillman3
-
49
-
-
0024811105
-
Specific disruption of intermediate filaments and the nuclear lamina by the 19-kDa product of the adenovirus E1B oncogene
-
edn 2
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 9886-9890
-
-
White1
Cipriani2
-
50
-
-
0028222955
-
Bcl-2 blocks p53-dependent apoptosis
-
of special interest, The authors show that induction of apoptosis by co-expression of EIA and wild-type pS3 is effectively blocked by expression of the bcl-2 gene. Bcl-2 diverts the activity of pS3 from induction of apoptosis to induction of growth arrest.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 2556-2563
-
-
Chiou1
Rao2
White3
-
51
-
-
0028274733
-
Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes
-
(1994)
Cancer Res
, vol.54
, pp. 2468-2471
-
-
Akao1
Otsuki2
Kataoka3
Ito4
Tsujimoto5
-
52
-
-
0028238213
-
Immediate early up-regulation of bax expression by p53 but not TGFβ1: a paradigm for distinct apoptotic pathways
-
of outstanding interest, Both p53 and TGFβ1 can induce apoptosis in M1 myeloid leukemia cells, with p53-induced apoptosis showing a more rapid kinetics than TGFβ1-induced apoptosis. Both p53 and TGFβ1 down-regulate endogenous bcl-2 expression, but only p53 activates bax expression. This difference may be, at least partially, responsible for the more rapid rate of apoptosis induced by p53 compared to by TGFβ1.
-
(1994)
Oncogene
, vol.9
, pp. 1791-1798
-
-
Selvakumaran1
Lin2
Miyashita3
Wang4
Krajewski5
Reed6
Hoffman7
Liebermann8
-
53
-
-
0028335717
-
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
-
of outstanding interest, These authors show that p53 knockout mice exhibit increases in Bcl-2 level and decreases in Bax level in a number of tissues and cell types. This provides in vivo evidence that p53 down-regulates bcl-2 expression and up-regulates bax expression.
-
(1994)
Oncogene
, vol.9
, pp. 1799-1805
-
-
Miyashita1
Krajewski2
Krajewska3
Wang4
Lin5
Liebermann6
Hoffman7
Reed8
-
54
-
-
0028070989
-
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
-
of outstanding interest, Apoptosis induced by ultraviolet radiation is dependent on wild-type p53. It is shown in this paper that p53 can mediate radiation-induced apoptosis even in the presence of RNA synthesis or protein synthesis inhibitors, suggesting that the transcriptional activation by p53 is not required for its activity in mediating ultraviolet radiation induced apoptosis.
-
(1994)
Nature
, vol.370
, pp. 220-223
-
-
Caelles1
Helmberg2
Karin3
-
55
-
-
0023697978
-
Tumor necrosis factor can induce both apoptotic and necrotic forms of cell lysis
-
(1988)
J Immunol
, vol.141
, pp. 2629-2634
-
-
Laster1
Wood2
Gooding3
-
57
-
-
0026726631
-
Virus proteins that counteract host immune defenses
-
(1992)
Cell
, vol.71
, pp. 5-7
-
-
Gooding1
-
61
-
-
0025950667
-
Programmed cell death in the immune system
-
(1991)
Adv Immunol
, vol.50
, pp. 55-85
-
-
Cohen1
-
64
-
-
0027260656
-
Epstein-Barr virus-encoded BHRFI protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death
-
of outstanding interest, These authors present evidence that an EBV early lytic cycle protein, BHRFI, which has limited amino acid sequence similarity to Bcl-2 protein, acts like Bcl-2 in that it can enhance cell survival under conditions that induce apoptosis (serum depletion or ionophore treatment). BHRFI also resembles Bcl-2 in its subcellular localization.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 8479-8483
-
-
Henderson1
Huen2
Rowe3
Dawson4
Johnson5
Rickinson6
-
65
-
-
0022971142
-
Cloning and structural analysis of cDNA for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
-
of outstanding interest
-
(1986)
Cell
, vol.47
, pp. 19-28
-
-
Cleary1
Smith2
Sklar3
-
66
-
-
0028304644
-
Epstein-Ban virus BHRFI protein protects against cell death induced by DNAdamaging agents and heterologous viral infection
-
of outstanding interest, This paper shows that the BHRFI protein of EBV can protect against apoptotic cell death induced by DNA-damaging agents or by an E1B 19 kDa defective mutant of adenovirus. This suggests that BHRFI is functionally similar to the adenovirus El B 19 kDa protein.
-
(1994)
Virology
, vol.201
, pp. 404-407
-
-
Tarodi1
Subramanian2
Chinnadurai3
-
67
-
-
0026344133
-
Prevention of apoptosis by a baculovirus gene during infection of insect cells
-
(1991)
Science
, vol.254
, pp. 1388-1390
-
-
Clem1
Fechheimer2
Miller3
-
68
-
-
0026800707
-
Site-specific mutagenesis of the 35-kilodalton protein gene encoded by Autographa califomica nuclear polyhedrosis virus: cell line-specific effects on virus replication
-
(1992)
J Virol
, vol.66
, pp. 5525-5533
-
-
Hershberger1
Dickson2
Friesen3
-
69
-
-
0027215907
-
Apoptosis reduces both the in vitro replication and the in vivo infectivity of a baculovirus
-
of special interest, This paper describes the effects of mutations in the p35 gene on baculovirus infection of either insect larvae or cultured cell lines.
-
(1993)
J Virol
, vol.67
, pp. 3730-3738
-
-
Clem1
Miller2
-
70
-
-
0025820485
-
Identification of upstream promoter elements mediating early transcription from the 35,000molecular-weight protein gene of Autographa califomica nuclear polyhedrosis virus
-
(1991)
J Virol
, vol.65
, pp. 4006-4016
-
-
Dickson1
Friesen2
-
71
-
-
0028175963
-
The apoptotic suppressor p35 is required early during baculovirus replication and is targeted to the cytosol of infected cells
-
of special interest, This paper characterizes the timing of p35 expression and subcellular localization of p35 during baculovirus infection. Early expression of the p35 gene during viral infection is required for it to prevent apoptosis. The protein is localized predominantly to the cytosol.
-
(1994)
J Virol
, vol.68
, pp. 3467-3477
-
-
Hershberger1
LaCount2
Friesen3
-
72
-
-
0028271740
-
Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorbabdids elegans
-
of outstanding interest, Expression of the AcMNPV p35 gene inhibits programmed cell death during normal G elegans development, and it can also rescue a ced-9 loss-of-function mutant.
-
(1994)
EMBO J
, vol.13
, pp. 2023-2028
-
-
Sugimoto1
Friesen2
Rothman3
-
74
-
-
0027537461
-
An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif
-
••] annotation
-
(1993)
J Virol
, vol.67
, pp. 2168-2174
-
-
Crook1
Clem2
Miller3
-
75
-
-
0028274132
-
An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs
-
This paper and [74••] describe the cloning and initial characterization of the iap gene from two baculoviruses. Either iap gene product can substitute functionally for p35 to prevent apoptosis. The two iap gene products share similar amino acid sequence, but neither has sequence homology to p35.
-
(1994)
J Virol
, vol.68
, pp. 2521-2528
-
-
Birnbaum1
Clem2
Miller3
-
76
-
-
0024706911
-
Characterization of the genetic organization of the Hind-111 M region of the multicapsid nuclear polyhedrosis virus of Orgyia-pseudotsugata reveals major differences among baculoviruses
-
(1989)
J Gen Virol
, vol.70
, pp. 1815-1828
-
-
Gombart1
Blissard2
Rohrmann3
-
77
-
-
0026539149
-
134.5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 3266-3270
-
-
Chou1
Roizman2
|