Evidence that Aβ42 is the real culprit in alzheimer's disease

Annals of Neurology

Volumn 37, Issue 3, 1995, Pages 287-288

  Younkin, Steven G ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; CHROMOSOME 21; DEMENTIA; EDITORIAL; GENE LOCUS; GENE MUTATION; HUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SENILE PLAQUE; TRISOMY 21;

ADULT; ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMAL; APOLIPOPROTEINS E; CEREBRAL CORTEX; DOWN SYNDROME; HUMAN;

EID: 0028945660     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.410370303     Document Type: Editorial

References (15)

1. Genetic linkage evidence for a familial Alzheimer's disease locus on chromo some 14
2. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
3. Production of the Alzheimer amyloid β protein by normal proteolytic processing
4. Amyloid β‐peptide is produced by cultured cells during normal metabolism
5. Isolation and quantitation of soluble Alzheimer's β‐peptide from biological fluids
6. Characterization of β amyloid peptide from human cerebrospinal fluid
7. An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (βAPP717) mutants
8. Mutation of the β‐amyloid precursor protein in familial Alzheimer's disease increases β‐protein production
9. Release of excess amyloid β protein from a mutant amyloid β protein precursor
10. Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome
11. Structural alterations in the peptide backbone of β‐amyloid core protein may account for its deposition and stability in Alzheimer's disease
12. Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease
13. Visualization of Aβ42(43) and Aβ40 in senile plaques with end‐specific Aβ monoclonals: evidence that an initially deposited species is Aβ42(43)
14. Most amyloid β protein (Aβ) in Alzheimer's disease brain ends at Aβ42,43
15. Amyloid‐associated proteins al‐antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β‐protein into filaments