α and α Interferons and Their Receptor and Their Friends and Relations

Journal of Interferon and Cytokine Research

Volumn 15, Issue 1, 1995, Pages 3-26

  Uzé, Gilles ^a   Lutfalla, Georges ^a   Mogensen, Knud E ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; CYTOKINE RECEPTOR; INTERFERON RECEPTOR;

AMINO ACID SEQUENCE; GENETICS; HUMAN; MOUSE; NOMENCLATURE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

AMINO ACID SEQUENCE; ANIMAL; CHROMOSOME MAPPING; CYTOKINES; HUMAN; INTERFERON TYPE I; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, INTERFERON; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TERMINOLOGY;

EID: 0028944489     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.1995.15.3     Document Type: Article

References (189)

1. AGUET, M., and MOGENSEN, K.E. (1983). Interferon receptors. In: Interferon, Vol. 5. I. Gresser (ed.) London: Academic Press, pp. 1–22.
2. ZOON, K.C., and ARNHEITER, H. (1984). Studies of the interferon receptors. Pharmacol. Ther. 24, 259-278.
3. RUBINSTEIN, M., and ORCHANSKY, P. (1986). The interferon receptors. CRC Crit. Rev, Biochem. 21, 249-275.
4. LANGER, J.A., and PESTKA, S. (1988). Interferon receptors. Immunol. Today 9, 393-399.
5. BRANCA, A.A. (1988). Interferon receptors. In Vitro Cell. Dev. Biol. 24, 155-165.
6. GROSSBERG, S.E., TAYLOR, J.L., and KUSHNARYOV, V.M. (1989). Interferon receptors and their role in interferon action. Experientia 45, 508-513.
7. MOGENSEN, K.E., UZ6, G., and EID, P. (1989). The cellular receptor of the alpha-beta interferons. Experientia 45, 500-508.
8. COLAMONICI, O.R., and PFEFFER, L.M. (1991). Structure of the human interferon alpha receptor. Pharmacol. Ther. 52, 227-233.
9. MARIANO, T.M., DONNELLY, R.J., SOH, J., and PESTKA, S. (1992). Structure and function of the type I interferon receptor. In: Interferon Principles and Medical Applications. S. Baron, D. Coppenhaver, F. Diazani, W.R. Fleischman, T.K. Hughes, G.R. Klimpel, D.W. Niesel, G.T. Stanton, and S.K. Tyring (eds.) Galveston: University of Texas Medical Branch, pp. 129–138.
10. LEVY, D., and DARNELL, I.E. (1990). Interferon-dependent transcriptional activation: signal transduction without second messenger involvement? New Biol. 2, 923-928.
11. KERR, I.M., and STARK, G.R. (1991). The control of inter-feron-inducibie gene expression. FEBS Lett. 285, 194-198.
12. PELLEGRINI, S., and SCHINDLER, C. (1993). Early events in signalling by interferons. Trends Biochem. Sci. 18, 338-342.
13. DARNELL, I.E., JR., KERR, I.M., and STARK, G.R. (1994). Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421.
14. BAZAN, J.F. (1989). A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors and the p75 IL-2 receptor P-chain. Biochem. Biophys. Res. Commun. 164, 788-795.
15. COSMAN, D., LYMAN, S.D., IDZERDA, R.L., BECKMANN, M.P., PARK, L.S., GOODWIN, R.G., and MARCH, C.J. (1990). A new cytokine receptor family. Trends Biochem. Sci. 15, 265-270.
16. BAZAN, J.F. (1990). Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87,6934-6938.
17. BAZAN, J.F. (1990). Haemopoietic receptors and helical cytokines. Inmiunol. Today 11, 350-354.
18. THOREAU, E., PETRIDOU, B., KELLY, P.A., DJIANE, J., and MORNON, J.-P. (1991). Structural symmetry of the extracellular domain of the cytokine/growth hormone/prolactin receptor family and interferon receptors revealed by hydrophobic cluster analysis. FEBS Lett. 282, 16-31.
19. NICOLA, N.A., and METCALF, D. (1991). Subunit promiscuity among hemapoietic growth factor receptors. Cell 67,1-4.
20. LUTFALLA, G., GARDINER, K., PROUDHON, D., VIELH, E., and UZE, G. (1992). The structure of the human interferon alpha/beta receptor gene. J. Biol. Chem. 267, 2802-2809.
21. SPRANG, S.R., and BAZAN, J.F. (1993). Cytokine structural taxonomy and mechanisms of receptor engagement. Curr. Opin. Struct. Biol. 3, 815-827.
22. STAHL, N., and YANCOPOULOS, G.D. (1993). The alphas, betas, and kinases of cytokine receptor complexes. Cell 74, 587-590.
23. STAHL, N., BOULTON, T.G., FARRUGGELLA, T., IP, N.Y., DAVIS, S., WITTHUHN, B.A., QUELLE, F.W., SIL-VENNOINEN, O., BARBIERI, G., PELLEGRINI, S., IHLE, J.N., and YANCOPOULOS, G.D. (1994). Association and activation of Jak-Tyk kinases by CNTF-LIF-0SM-IL6 beta receptor components. Science 263,92-95.
24. WEISSMANN, C., and WEBER, H. (1986). The interferon genes. Prog. Nucleic Acid Res. Mol. Biol. 33, 251-300.
25. MITSUI, Y., SENDA, T., SHIMAZU, T., MATSUDA, S., and UTSUMI, J. (1993). Structural, functional and evolutionary implications of the three-dimensional crystal structure of murine interferon beta. Pharmacol. Ther. 58, 93-132.
26. SENDA, T., SHIMAZU, T., MATSUDA, S., KAWANO, G., SHIMIZU, H., NAKAMURA, K.T., and MITSUI, Y. (1992). Three-dimensional crystal structure of recombinant murine interferon-beta. EMBO J. 11, 3193-3201.
27. MURGOLO, N.J., WINDSOR, W.T., HRUZA, A., REICHERT, P., TSARBOPOULOS, A., BALDWIN, S., HUANG, E.H., PRAMANIK, B., EALICK, S., and TROTTA, P.P. (1993). A homology model of human interferon alpha-2. Proteins 17,62-74.
28. KORN, A.P., ROSE, D.R., and FISH, E.N. (1994). Threedimensional model of a human interferon alpha consensus sequence. J. Interferon Res. 14, 1-9.
29. DIMARCO, S., GRUTTER, M.G., PRIESTLE, J.P., and HO-RISBERGER, M.A. (1994). Mutational analysis of the stnicture-function relationship in interferon-alpha. Biochem. Biophys. Res. Commun. 202, 1445-1451.
30. HORISBERGER, M.A., and DIMARCO, S. (1994). IFN-alpha hybrids. Pharmacol. Ther. In Press.
31. UZE, G., LUTFALLA, G., and GRESSER, I. (1990). Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. Cell. 60, 225-234.
32. UZE, G., LUTFALLA, G., EID, P., MAURY, C., BANDU, M.-T., GRESSER, 1., and MOGENSEN, K.E. (1991). Murine tumor cells expressing the gene for the human interferon alpha beta receptor elicit antibodies in syngeneic mice to the active form of the receptor. Eur. J. Immunol. 21, 447-451.
33. UZE, G., LUTFALLA, G., BANDU, M.-T., PROUDHON, D., and MOGENSEN, K.E. (1992). Behavior of a cloned murine interferon alpha beta receptor expressed in homospecific or heterospecific background. Proc. Natl. Acad. Sci. USA 89, 4774-4778.
34. VAN DEN BROECKE, C., and PFEFFER, L.M. (1988). Characterization of interferon-alpha binding sites on human cell lines. J. Interferon Res. 8, 803-811.
35. CONSTANTINESCU, S.N., CROZE, E, WANG, C., MURTI, A., BASU, L., MULLERSMAN, J.E., and PFEFFER, L.M. (1994). The role of the IFNaRl chain in the structure and transmembrane signaling of the IFN o/p receptor complex. Proc. Natl. Acad. Sci. USA 91,9602-9606.
36. PFEFFER, L.M. (1994) Personal communication. University of Tennessee Health Science Center, Department of Pathology, Memphis, TN.
37. COLAMONICI, O.R., and DOMANSKI. P. (1993). Identification of a novel subunit of the type I interferon receptor localized to chromosome 21. J. Biol. Chem. 268, 10895-10899.
38. EID, P., and MOGENSEN, K.E. (1990). Detergent extraction of the human alpha-beta interferon receptor: a soluble form capa- ble of binding interferon. Biochim. Biophys. Acta 1034, 114-117.
39. EID, P., and TOVEY, M.G. (1995). Characterization of a domain of the human type I interferon receptor involved in ligand binding. J. Interferon Res. In press.
40. NOVICK, D., COHEN, B., and RUBINSTEIN, M. (1994). The human interferon alpha/beta receptor: characterization and molecular cloning. Cell 77, 391-400.
41. SLATE, D.L., RUDDLE, F.H., and TAN, Y.H. (1981). Genetic control of the interferon system. In: Interferon, Vol. 3.1. Gresser (ed.) London: Academic Press, pp. 65–76.
42. LANGER, J.A., RASHIDBAIGI, A., LAI, L.-W., PATTERSON, D., and JONES, C. (1990). Sublocalization on chromosome 21 of human interferon-alpha receptor gene and the gene for an interferon-gamma response protein. Somat. Cell Mol. Genet. 16,231-240.
43. HERTZOG, P.J., HWANG, S.Y., HOLLAND, K.A., TYMMS, M.J., Lanello, R., and KOLA, I. (1994). A gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons. J. Biol. Chem. 269, 14088-14093.
44. GABORIAUD, C., UZÉ, G., LUTFALLA, G., and MOGENSEN, K.E. (1990). Hydrophobic cluster analysis reveals duplication in the external structure of human alpha interferon receptor and homology with gamma interferon receptor external domain. FEBS Lett. 269, 1-3.
45. LUTFALLA, G., ROECKEL, N., MOGENSEN, K.E., MATTEI, M.-G., and UZÉ, G. (1990). Assignment of the human interferon alpha receptor gene to chromosome 21q22.1 by in situ hybridization. J. Interferon Res. 10, 515-517.
46. MCINNIS, M.G., LUTFALLA, G., SLAUGENHAUPT, S., PETERSON, M.B., UZÉ, G., CHAKRAVARTI, A., and AN-TONARAKIS, S.E. (1991). Linkage mapping of highly informative DNA polymorphisms within the human interferon alpha receptor gene on chromosome 21. Genomics 11, 573-576.
47. O'BRIEN, S.J., WOMACK, J.E., LYONS, L.A., MOORE, K.J., JENKINS, N.A., and COPELAND, N.G. (1993). Anchored reference loci for comparative genome mapping in mammals. Nature Genet. 3, 103-112.
48. NAKAGAWA, Y., KOSUGI, H., MIYAJIMA, A., ARAI, K., and YOKOTA, T. (1994). Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. J. Biol. Chem. 269, 10905-10912.
49. LUTFALLA, G., GARDINER, K., and UZÉ, G. (1993). A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. Genomics 15, 366-373.
50. KREMER, E., BAKER, E., D'ANDREA, R.J., SLIM, R., PHILLIPS, H., MORETTI, P.A.B., LOPEZ, A.F., PETIT, C., VADAS, M.A., SUTHERLAND, G.R., and GOODAL, G.J. (1993). A cytokine receptor gene cluster in the X-Y pseudoautosomal region? Blood 82, 22-28.
51. SOH, J., DONNELLY, R.J., KOTENKO, S., MARIANO, T.M., COOK, J.R., WANG, N., EMANUEL, S.L., SCHWARTZ, B., MIKI, T., and PESTKA, S. (1994). Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. Cell 76, 793-802.
52. SOH, J., MARIANO, T.M., LIM, J.K., IZOTOVA, L., MI-ROCHNITCHENKO, O., SCHWARTZ, B., LANGER, J.A., and PESTKA, S. (1994). Expression of a functional type I interferon receptor in hamster cells: application of functional Y AC screening. J. Biol. Chem. 269, 18102-18110.
53. CLEARY, C M., DONNELLY, R.J., SOH, J., MARIANO, T.M., and PESTKA, S. (1994). Knockout and reconstitution of a functional human type I receptor complex. J. Biol. Chem., 269, 18747-18749.
54. GARDINER, K. (1994). Personal communication. Eleanor Roosevelt Cancer Institute, Denver, CO.
55. AGUET, M., DEMBIC, Z., and MERLIN, G. (1988). Molecular cloning and expression of the human interferon-7 receptor. Cell 55, 273-280.
56. HEMMl, S., BOHNI, R., STARK, G., DI MARCO, F., and AGUET, M. (1994). A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. Cell 76, 803-810.
57. COOK, J.R., EMANUEL, S.L., DONNELLY, R.J., SOH, J., MARIANO, T.M., SCHWARTZ, B., RHEE, S., and PETSKA, S. (1994). Sublocalization of the human interferon gamma receptor accessory factor gene and characterization of accessory factor activity by yeast artificial chromosomal fragmentation. J. Biol. Chem. 269, 7013-7018.
58. CHENG, S., LUTFALLA, G., UZE, G., CHUMAKOV, I.M., and GARDINER, K. (1993). GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome
59. Mammal. Genome 4, 338-342.
60. LANGER, J.A., PUVANAKRISHNAN, R., and WOMACK, J.E. (1992). Somatic cell mapping of the bovine interferon-alpha receptor. Mammal. Genome 3, 237-240.
61. BENOIT, P., MAGUIRE, D., PLAVEC, L, KOCHER, H., TOVEY, M., and MEYER, F. (1993), A monoclonal antibody to recombinant human interferon alpha receptor inhibits biological activity of several species of IFN alpha, IFN beta, and IFN omega. J. Immunol. 150,707-716.
62. MOUCHEL-VIELH, E., LUTFALLA, G., MOGENSEN, K.E., and UZE, G. (1992). Specific antiviral activities of the human alpha interferons are determined at the level of receptor (IFNAR) structure. FEBS Lett. 313, 255-259.
63. MÜLLER, U., STEINHOFF, U., REIS, L.F.L., HEMMI, S., PAVLOVIC, J., ZINKERNAGEL, R.M., and AGUET, M. (1994). Functional role of type I and type II interferons in antiviral defense. Science 264, 1918-1921.
64. NOVICK, D., COHEN, B., and RUBINSTEIN, M. (1992). Soluble interferon-α receptor molecules are present in body fluids. FEBS Lett. 314, 445-448.
65. HERTZOG, P. (1994). Personal communication, Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia.
66. COLAMONICI, O.R., PFEFFER, L.M., D'ALESSANDRO, F., PLATANIAS, L.C., GREGORY, S., ROSOLEN, A., NOR-DAN, R., CRUCIANI, R.A., and DIAZ, M.O. (1992). Multichain structure of the IFN-α receptor on haematopoietic cells. J. Immunol. 14g, 2126-2132.
67. LIM, J.-K., and LANGER, J.A. (1993). Cloning and characterization of a bovine alpha interferon receptor. Biochim. Biophys. Acta 1173, 314-319.
68. LANGER, J. A. (1994). Personal communication. Dept. Molecular Genetics Microbiology, UMDNJ, New Jersey.
69. LIM, J.-K., XIONG, J., CARRASCO, N., and LANGER, J.A. (1994). Intrinsic ligand binding properties of the human and bovine alpha interferon receptors. FEBS Lett. 350, 281-286.
70. JOSHI, A.R., SARKAR, F.H., and GUPTA, S.L. (1982). Interferon receptors: cross-linking of human leukocyte interferon alpha 2 to its receptor on human cells. J. Biol. Chem. 257,13884-13887.
71. FALTYNEK, C.R., BRANCA, A.A., MCCANDLESS, S., and BAGLIONI, C. (1983). Characterization of an interferon receptor on human lymphoblastoid cells, Proc. Natl. Acad. Sei. USA 80, 3269-3273.
72. EID, P., BANDU, M.-T., UZÉ, G., and MOGENSEN, K.E. (1988). Interferon removes its own receptors as it blocks the division of Daudi cells. Eur. J. Biochem. 171, 675-682.
73. VELAZQUEZ, L., FELLOUS, M., STARK, G.R., and PELLEGRINI, S. (1992). A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 70, 313-322.
74. COLAMONICI, O.R., DOMANSKI, P., KROLEWSKI, J.J., FU, X. Y., REICH, N.C., PFEFFER, L.M., SWEET, M E., and PLATANIAS, L.C. (1994). Interferon a (IFNa) signaling in cells expressing the variant form of the type I IFN receptor. J. Biol. Chem. 269, 5660-5665.
75. ABRAMOVICH, C., RATOVITSKI, E., LUNDGREN, E., and REVEL, M. (1994). Identification of mRNAs encoding two different soluble forms of the human interferon a-receptor. FEBS Lett. 338,295-300.
76. HANNIGAN, G.E., and WILLIAMS, B.R.G. (1986). Transcriptional regulation of interferon-responsive genes is closely linked to interferon receptor occupancy. EMBO J. 5, 1607-1613.
77. WILLIAMS, B.R.G. (1991). Transcriptional regulation of interferon-stimulated genes. Eur. J. Biochem. 200, 1-11.
78. KISHIMOTO, T., TAGA, T., and AKIRA, S. (1994). Cytokine signal transduction. Cell 76, 253-262.
79. PELLEGRINI, S., JOHN, J., SHEARER, M., KERR, I.M., and STARK, G.R. (1989). Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol. Cell, Biol. 9, 4605-4612.
80. MULLER, M., BRISCOE, J., LAXTON, C., GUSCHIN, D., ZIEMIECKI, A., SILVENNOINEN, O., HARPUR, A.G., BARBIERI, G., WITTHUHN, B.A., SCHINDLER, C., PELLEGRINI, S., WILKS, A.F., IHLE, J.N., STARK, G.R., and KERR, I.M. (1993). The protein tyrosine kinase JAKl complements defects in interferon alpha:beta and gamma signal transduction. Nature 366, 129-135.
81. NICHOLSON, S.E., OATES, AC., HARPUR, A.G., ZIEMIECKI, A., WILKS, A.F., and LAYTON, J.E. (1994). Tyrosine kinase JAKl is associated with granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. Proc. Natl. Acad. Sci. USA 91, 2985-2988.
82. TANAKA, N., ASAO, H., OHBO, K., ISHII, N., TAKE-SHITA, T., NAKAMURA, M., SASAKI, H., and SUG-AMURA, K. (1994). Physical association of JAKl and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains. Proc. Natl. Acad. Sci. USA 91, 7271-7275.
83. IMPROTA, T., SCHINDLER, C., HORVATH, C.M., KERR, I.M., STARK, G.R., and DARNELL, J.E. (1994). Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Statll3 protein is phosphorylated independently of Stat91 protein. Proc. Natl. Acad. Sci. USA 91,4776-4780.
84. LEUNG, S., QURESHI, S.A., KERR, I.M., DARNELL, J.E., and STARK, G.R. (1994). Role of STAT2 in the interferon a/p signaling pathway. Mol. Cell. Biol. In press.
85. DAVID, M., and LARNER, A.C. (1992). Activation of transcription factors by interferon-alpha in a cell-free system. Science 257, 813-815.
86. DAVID, M., ROMERO, G., ZHANG, Z. Y., DIXON, J.E., and LARNER, A.C. (1993). In vitro activation of the transcription factor ISGF3 by interferon a involves a membrane-associated tyrosine phosphatase and tyrosine kinase. J. Biol. Chem. 268, 6593-6599.
87. BARBIERI, G., VELAZQUEZ, L., SCROBOGNA, M., FELLOUS, M., and PELLEGRINI, S. (1994). Activation of the protein kinase tyk2 by interferon a/p. Eur. J. Biochem. 223, 427-435.
88. COLAMONICI, O R, UYTTENDAELE, H., DOMANSKI, P., YAN, H., and KROLEWSKI, J.J. (1994). pl35tyk2, an inter- feron-a-activated tyrosine kinase, is physically associated with an interferon-α receptor. J. Biol. Chem. 269, 3518-3522.
89. VELAZQUEZ, L., MOGENSEN, K.E., BARBIERI, G., FEL-LOUS, M., UZE, G., and PELLEGRINI, S. Distinct domains of the tyrosine Kinase tyk2 required for high affinity binding of a/p IFNs and for signal transduction. J. Biol. Chem. In press.
90. IHLE, J.N., WITTHUHN, B.A., QUELLE, F.W., YAMAMOTO, K., THIERELDER, W.E., KREIDER, B., and SIL-VENNOINEN, O. (1994). Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem. Sci. 19,222-227.
91. HANKS, S.K., and QUINN, A.-M. (1991). Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol. 200, 38-42.
92. VELAZQUEZ, L., BARBIERI, G., MOGENSEN, K.E., UZE, G., FELLOUS, M., and PELLEGRINI, S. (1994). How does interferon tickle Tyk. J. Cell. Biochem. S18B, 203.
93. PLATANIAS, L.C., UDDIN, S., and COLAMONICI, O.R. (1994). Tyrosine phosphorylation of the a and P subunits of the type I interferon receptor. J. Biol. Chem. 269, 17761-17764.
94. SEKELLICK, M.J., FERRANDINO, A.F., HOPKINS, D.A., and MARCUS, P.I. (1994). Chicken interferon gene: cloning, expression and analysis. J. Interferon Res. 14, 71-79.
95. WILSON, V., JEFFREYS, A.J., BARRIE, P.A., BOSELEY, P.G., SLOCOMBE, P.M., EASTON, A., and BURKE, D.C. (1983). A comparison of vertebrate gene families detected by hybridization with human IFN-P mRNA. J. Mol. Biol. 166, 457-475.
96. DE VOS, A.M., ULTSH, M., and KOSSIAKOFF, A.A. (1992). Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255, 306-312.
97. WELLS, J.A., FUH, G., LOWMAN, H., CLACKSON, T., and CUNNINGHAM, B. (1994). Probing and designing growth hor-mone-receptor interactions. J. Cell. Biochem. S18B, 199.
98. CUNNINGHAM, B.C., and WELLS, J.A. (1989). High-resolu-tion epitope mapping of hGH receptor interactions by alanine scanning mutagenesis. Science 224, 1081-1084.
99. CUNNINGHAM, B.C., ULTSCH, M., DE VOS, A.M., MULKERRIN, M.G., CLAUSE, K.R., and WELLS, J.A. (1991). Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 254, 821-825.
100. BASS, S.H., MULKERRIN, M.G., and WELLS, J.A. (1991). A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor. Proc. Natl. Acad. Sci. USA 88,4498-4502.
101. ROBINSON, R.C., GREY, L.M., STAUNTON, D., VAN-KELECOM, H., VERNALLIS, A.B., MOREAU, J.F., STUART, D.L. HEATH, J.K., and JONES, E.Y. (1994). The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. Cell 77,1101-1116.
102. ROZWARSKI, D.A., GRONENBORN, A.M., CLORE, G.M., BAZAN, J.F., BOHM, A., WLODAWER, A., HATADA, M., and KARPLUS, P.A. (1994). Structural comparisons among the short-chain helical cytokines. Structure 15, 159-173.
103. SENDA, T., MATSUDA, S., KURIHARA, H., NAKAMURA, K.T., KAWANO, G., SHIMIZU, H., MIZUNO, H., and MITSUI, Y. (1990). Three-dimensional structure of recombinant murine interferon beta. Proc. Jpn. Acad. Sci. 66B, 77-80.
104. SHAFFERMAN, A., VELAN, B., COHAN, S., LEITNER, M., and GROSFELD, H. (1987). Specific residues within an amino-terminal domain of 35 residues of interferon alpha are responsible for recognition of the human interferon alpha cell receptor and for triggering biological effects. J. Biol, Chem. 262, 6227-6237.
105. CAPON, D.J., SHEPARD, H,M., and GOEDDEL, D.V. (1985). Two distinct families of human and bovine interferon- alpha genes are coordinately expressed and encode functional polypeptides. Mol. Cell. Biol. 5,768-779.
106. STEWART, H.J., MCCANN, S.H.E., BARKER, P.J., LEE, K.E., GAMMING, G.E., and FLINT, A.P.F. (1987), Interferon sequence homology and receptor binding activity of ovine trophoblast antiluteolytic protein. J. Endocrinol. 115, R13-R15.
107. WEBER, H., VALENZUELA, D., LUJBER, G., GUBLER, M., and WEISSMANN, C, (1987). Single amino acid changes that render human interferon alpha2 biologically active on mouse cells. EMBOJ. 6, 591-598.
108. NAKAMURA, N., SUDO, T., MATSUDA, S., and YANAI, A, (1992). Molecular cloning of feline interferon cDNA by direct expression. Biosci. Biotechnol. Biochem. 56, 211-214.
109. MEGE, D., LEFEVRE, F., and LABONNARDIÉRE, C. (1991). The porcine family of interferon-omega: cloning, structural analysis and functional studies of five related genes. J, Interferon Res, 11, 341-350.
110. GRESSER, I., BANDU, M.-T., BROUTY-BOYE, D., and TOVEY, M.G. (1974). Pronounced antiviral activity of human interferon on bovine and porcine cells. Nature (Lond.) 251, 543-545.
111. DESMYTER, J., and STEWART, W.E., II (1976). Molecular modification of interferon: attainment of human interferon in a conformation active on cat cells but inactive on human cells. Virology 70, 451-458.
112. MEISTER, A., UZÉ, G., MOGENSEN, K.E., GRESSER, I., TOVEY, M.G., GRÜTTER, M., and MEYER, F. (1986). Biological activities and receptor binding of two human recombinant interferons and their hybrids. J, Gen, Virol. 67, 1633-1643.
113. HOCHKEPPEL, H.K., GRÜTTER, M., HORISBERGER, M.A., and LAZDINS, J.K. (1992). Human IFN-alpha hybrids. Drugs Future 17, 899-914.
114. STREULI, M., HALL, A., BOLL, W., STEWART, W.E., II, NAGATA, S., and WEISSMANN, C. (1981). Target cell specificity of two species of human interferon alpha produced in E. coli and of hybrid molecules derived from them. Proc. Natl. Acad. Sci. USA 78, 2848-2852.
115. WECK, P.K., APPERSON, S., STEBBING, N., GRAY, P.W., LEUNG, D., SHEPARD, M.H., and GEODDEL, D.V. (1981). Antiviral activities of hybrids of two major human leukocyte interferons. Nucleic Acids Res. 9, 6153-6166.
116. REHBERG, E., KELDER, B., HOAL, E.G., and PESTKA, S. (1982). Specific molecular activities of recombinant and hybrid leukocyte interferons. J. Biol. Chem. 257, 11497-11502.
117. FRANKE, A.E., SHEPARD, M., HOUCK, C.M., LEUNG, D,W., GOEDDEL, D.V., and LAWN, R.M. (1982). Carboxy-terminal region of hybrid leukocyte interferons affects antiviral specificity. DNA 1, 223-230.
118. MOREHEAD, H., JOHNSTON, P.D., and WETZEL, R. (1984). Roles of the 29-138 disulphide bond of subtype A of human alpha interferon in its antiviral activity and conformational stability. Biochemistry 23, 2500-2507.
119. BEILHARZ, M.W., NISBET, I T., TYMMS, M.J., HERT-ZOG, P.J., and LINNANE, A.W. (1986). Antiviral and antiproliferative activities of interferon a,: the role of cysteine residues. J, Interferon Res. 6, 677-685.
120. CAMBLE, R., PETTER, N.N., TRUEMAN, P., NEWTON, C.R., CARR, F.J., HOCKNEY, R.C., MOORE, V.E., GREENE, A.R., HOLLAND, D., and EDGE, M.D. (1986). Functionally important conserved amino-acids and interferon al-pha>2 identified with analogues produced from synthetic genes. Biochem. Biophys. Res. Conmiun. 134, 1404-1411.
121. TYMMS, M.J., MCINNES, B., WAINE, G.J., CHEETHAM, B.F., and LINNANE, A.W. (1989). Functional significance of amino acid residues within conserved hydrophilic regions in human interferons-alpha. Antiviral Res. 12, 37-48.
122. MCMULLEN, G.L., SATTAYASAI, N., HIBBS, A.R., and MARZUKI, S. (1990). Antipeptide antibodies against conserved regions of human interferons-a: evidence for conformational variation between IFN-α subtypes. Biochem. Int. 21,261-269.
123. WAINE, G.J., TYMMS, M.J., BRANDT, E.R., CHEETHAM, B.F., and LINNANE, A.W. (1992). Structure-function study of the region encompassing residues 26-40 of human interferon alpha4: identification of residues important for antiviral and antiproliferative activities. J. Interferon Res. 12,43-48.
124. CHEETHAM, B.F., MCINNES, B., MANTAMADIOTIS, T., MURRAY, P.J., AALIN, P., BOURKE, P., LINNANE, A.W., and TYMMS, M.J. (1991). Structure-function studies of human interferons-alpha: enhanced activity on human and murine cells. Antiviral Res. 15, 27-40.
125. MCINNES, B., CHAMBERS, P.J., CHEETHAM, B.F., BEILHARZ, M.W., and TYMMS, M.J. (1989). Structure-function studies of interferon-alpha; amino acid substitutions at the conserved residue tyrosine 123 in human interferon-alpha 1. J. Interferon Res. 9, 305-314.
126. UZÉ, G., BANDU, M.-T., EID, P., GRÜTTER, M., and MOGENSEN, K.E. (1988). Electrostatic interactions in the cellular dynamics of the interferon-receptor complex. Eur. J. Biochem. 171, 683-691.
127. HSH, E.N., BANERJEE, K., and STEBBING, N. (1989). The role of three domains in the biological activity of human interferon-alpha, J. Interferon Res. 9, 97-114.
128. FISH, E.N. (1992). Definition of receptor binding domains in interferon alpha. J. Interferon Res. 12, 257-266.
129. KERRY, J.A., TYMMS, M.J., and LINNANE, A.W. (1988). Conserved amino acid residues arginine 33 and tyrosine 123 are critical for the antiviral activity of murine interferon alpha-1. Biochem. Biophys. Res. Commun. 155, 714-719.
130. UZÉ, G., DI MARCO, S., MOUCHEL-VIELH, E., MON-NERON, D., BANDU, M.-T., HORISBERGER, M.A., DORQUES, A., LUTFALLA, G., and MOGENSEN, K.E. (1994). Eomains of interaction between alpha interferon and its receptor components. J. Mol. Biol. 243, 245-257.
131. EDGE, M.D., GAMBLE, R., MOORE, V.E., HOCKNEY, R.C., CARR, F.J., and FITTON, J.E. (1986). Interferon analogues from synthetic genes: an approach to protein stnicture-activity studies. In: Interferon, Vol. 7. I. Gresser (ed.) London: Academic Press, pp. 1–46.
132. PONTZER, C.H., OTT, T.L., BAZER, F.W., and JOHNSON, H.M. (1994). Structure function studies with interferon tau: evidence for multiple active sites. J. Interferon Res. 14,133-141.
133. MOGENSEN, K.E., and CANTELL, K. (1974). Loss of specific antigenicity on carbamidomethylation of mercaptoethanol-re-duced interferon of human leukocyte origin. Intervirology 2,52-55.
134. LIM, J.-K., and LANGER, J.A. (1993). Generation and characterization of antiidiotypic antibodies recognizing the interferonalpha receptor: implications for ligand-receptor interactions. J. Interferon Res. 13, 295-301.
135. RUF, W., SCHULLECK, J.R., STONE, M.J., and EDGING-TON, T.S. (1994). Mutational mapping of functional residues in tissue factor: identification of factor VII recognition determinants in both structural modules of the predicted cytokine receptor homology domain. Biochemistry 33, 1565-1572.
136. LING, L.E., ZAFARI, M., REARDON, D., BRICKELMEIER, M., GOELZ, S.E., and BENJAMIN, C.D. (1994). Personal communication. Biogen, Inc., Cambridge, MA.
137. COHEN, A., HANNIGAN, G.E., WILLIAMS, B.R.G., and LINGWOOD, C.A. (1987). Roles of globotriaosyl- and galabio-sylceramide in verotoxin binding and high affinity interferon receptors. J. Biol. Chem. 262, 17088-17091.
138. LINGWOOD, C.A., and SHIU, S.K. (1992). Glycolipidmodification of alpha2 interferon binding. Biochem. J. 283,25-26.
139. GHISLAIN, J., LINGWOOD, C.A., and FISH, E.N. (1994). Evidence for glycosphingolipid modification of the type 1 interferon receptor. J. Immunol. 153, 3655-3663.
140. STEIN, P.E., BOODHOO, A., TYRELL, G.J., BRUNTON, J.L., and READ, R.J. (1992). Crystal structure of the cell-binding B oligomer from E. coli. Nature 355, 748-750.
141. BERG, H., and PURCELL, E.M. (1977). The physics of chemoreception. Biophys. J. 20, 193-219.
142. DELISI, C. (1980). The biophysics of ligand-receptor interactions. Q. Rev, Biophys. 13, 201-230.
143. RYAN, T.A., MYERS, J., HOLOWKA, D., BAIRD, B., and WEBB, W.W. (1988). Molecular crowding on the cell surface. Science 239, 61-64.
144. LANGER, J.A., RASHIDBAIGI, G., and KEMPNER, E. (1994). Radiation inactivation of human gamma-interferon: cellular activation requires two dimers. Proc. Natl. Acad. Sci. USA 91,5818-5822.
145. HIMMLER, A., HAUPTMANN, R., ADOLF, G.R., and SWETLY, P. (1986). Molecular cloning and expression in Escherichia coli of equine type I interferons. DNA 5, 345-356.
146. SENDA, T., and MITSUI, Y. (1994). Crystal structure refinement of recombinant murine interferon-β. Protein Engineer. In press.
147. DRON, M., TOVEY, M.G., and UZÉ, G. (1986). Isolation of Daudi cells with reduced sensitivity to interferon. IV. Characterization of clones with altered binding of human interferon alpha subspecies. J. Gen. Virol. 67, 663-669.
148. SCHWABE, M., PRINCLER, G.L., and FALTYNEK, C.R. (1988). Characterization of the human type I interferon receptor by ligand blotting. Eur. J. Immunol. 18, 2009-2014.
149. MARCUCCI, F., and DE MAEYER, E. (1986). An interferon analogue, Ala 30,32,33 HuIFN-alpha2, acting as a HuIFN-al-pha2 antagonist on bovine cells. Biochem. Biophys. Res. Commun. 134, 1412-1418.
150. ABDEL-MEGUID, S.S., SHIEH, H. S., SMITH, W.W., DAY-RINGER, H E., VIOLAND, B.N., and BENTLE, L A. (1987). Three-dimensional structure of a genetically engineered variant of porcine growth hormone. Proc. Natl. Acad. Sci. USA 84, 6434-6437.
151. STRANDER, H., and EINHORN, S. (1977). Effect of human leukocyte interferon on the growth of osteosarcoma cells in tissue culture. Int. J. Cancer 19, 468-473.
152. OVERALL, M.L., CHAMBERS, P., and HERTZOG, P.J. (1992). Different interactions of interferon-α subtypes at the surface of epithelial and lymphoid cells. J. Interferon Res. 12,281-288.
153. OVERALL, M L., and HERTZOG, P.J. (1992), Functional analysis of interferon-α subtypes using monoclonal antibodies to interferon-a-4a: subtype reactivity, neutralisation of biological activities and epitope analysis. Mol. Immunol. 29, 391-399.
154. WANG, L., HERTZOG, P.J., GALANIS, M., OVERALL, M.L., WAINE, G.J., and LINNANE, A.W. (1994). Strucmre-function analysis of human IFN-a; mapping of a conformational epitope by homologue scanning. J. Immunol. 152, 705-715.
155. EALICK, S.E., COOK, W.J., VUAY-KUMAR, S., CARSON, M., NAGABUSHAN, T.L., TROTTA, P.P., and BUGG, C.E. (1991). Three dimensional structure of recombinant human interferon gamma. Science 252, 698-702.
156. MILBURN, M.V., HASSEL, A.M., LAMBERT, M.H., JORDAN, S R., PROUDFOOT, A.E., GRABER, P., and WELLS, T.N. (1993). A novel dimer configuration revealed by the crystal structure at 2,4 A resolution of human interleukin-5. Nature 363, 172-176.
157. PRESNELL, S.R., and COHEN, F.E. (1989). Topological distribution of the four-a-helix bundles. Proc. Natl. Acad. Sci. USA 86, 6592-6596.
158. DURIEZ, B., SOBRIER, M.L., DUQUESNOY, P., TIXIER-BOICHARD, M., DECUYPERE, E., COQUERELLE, G., ZEMAN, M., GOOSSENS, M., and AMSELEM, S. (1993). A naturally occurring growth hormone receptor mutation: in vivo and in vitro evidence for the functional importance of the WS motif common to all the cytokine receptor superfamily. Mol. Endocrinol. 7, 806-814.
159. STUBER, D., FRIEDLEIN, A., FOUNTOULAKIS, M., LAHM, H.W., and GAROTTA, G. (1993). Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity. Biochemistry 32, 2423-2430.
160. HARLOS, K., MARTIN, D.M.A., O'BRIEN, D.P., JONES, E.Y., STUART, D.I., POLIKARPOV, I., MILLER, A., TUD-DENHAM, E.G.D., and BOYS, C.W.G. (1994). Crystal structure of the extracellular region of human tissue factor. Nature 370, 662-666.
161. WOLF, S.F., TEMPLE, P.A., KOBAYASHI, M., YOUNG, D., DICIG, M., LOWER, L., DZIALO, R., FITZ, L., FER-ENZ, C., HEWICK, R.M., KELLEHER, K., HERRMANN, S.H., CLARK, S.C., AZZONI, L., CHAN, S.H., TRIN-CHIERI, G., and PERUSSIA, B. (1991). Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 145, 3074-3081.
162. DAVIES, T.L., ALDRICH, T.H., VALENZUELA, D., WONG, V., FURTH, M E., SQUINTO, S.P., and YANCO-POULOS, G.D. (1991). The receptor for ciliary neutrophic factor. Science 253, 59-63.
163. HARA, T., and MIYAJIMA, A. (1992). Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3). EMBO J. 11,1875-1884.
164. BURCH, P.R.J. (1976). The Biology of Cancer: A New Approach. Lancaster: MTP Press, pp. 51–54.
165. NIALL, H.D., HOGAN, M.L., SAUER, R., ROSENBLUM, I.Y., and GREENWOOD, F.C. (1971). Sequences of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication, Proc. Natl. Acad. Sci. USA(W, 866-869.
166. COOKE, N.E., COIT, D., SHINE, J., BAXTER, J.D., and MARTIAL, J.A. (1981). Human prolactin cDNA structural analysis and evolutionary comparisons. J. Biol. Chem. 256, 4007-4016.
167. ERICKSON, B.W., MAY, L., and SEHGAL, P.B. (1984). Internal duplication in the a, and P, interferons. Proc. Natl. Acad. Sci. USA 81,7171-7175.
168. TAMAI, T., SHIRAHATA, S., NOGUCHI, T., SAT, N., KIMURA, S., and MURAKAMI, H. (1993). Cloning and expression of flatfish (Paralichthys olivaceous) interferon cDNA. Biochim. Biophys. Acta 1174, 182-186.
169. MOYLE, W.R., CAMPBELL, R.K., MYERS, R.V., BERNARD, M.P., HAN, Y., and WANG, X. (1994). Co-evolution of ligand-receptor pairs. Nature 368, 251-255.
170. DE MAEYER, D., and DE MAEYER-GUIGNARD, J. (1988). Interferons and Other Regulatory Cytokines. New York: Wiley.
171. GRUNFELD, C., SOUED, M., MOSER, A.H., FIERS, W., DINARELLO, C.A., and FEINGOLD, K.R. (1991). Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1 and interleukin 6 but not by interferon alpha. Cancer Res. 51,2803-2807.
172. BENVENISTE, E.N. (1992). Inflammatory cytokines within the central nervous system: sources, function and mechanism of action. Am. J. Physiol. 263, Cl-16.
173. STRUIK, D.J. (1986). A Source Book In Mathematics, 1200-1800. Princeton, NJ: Princeton University Press, pp. 183–187.
174. PRICE, W.L. (1971). Graphs and Networks: An Introduction. London: Butterworths, Chap. 2.
175. MOGENSEN, K.E., and BANDU, M.-T. (1983). Kinetic evi- dence for an activation step following binding of human interferon alpha 2 to the membrane receptors of Daudi cells. Eur. J. Biochem. 134, 355-364.
176. THOM, R. (1977). Stabilité Structurelle et Morphogénèse. Paris Intereditions, p. 23, 32-33.
177. WAHLI, W., and MARTINEZ, E. (1991). Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression. FASEB J. 5, 2243-2249.
178. NOVICK, D., ENGELMANN, H., WALLACH, D., and RUBINSTEIN, M. (1989). Soluble cytokine receptors are present in normal human urine. J. Exp, Med. 170, 476-488.
179. GEARING, D.P., and COSMAN, D. (1991). Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell 66, 9-10.
180. TA VERNIER, J., TUYPENS, T., PLAETINCK, G., VERHEE, A., FIERS, W., and DEVOS, R. (1992). Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor a subunit. Proc. Natl. Acad. Sci. USA 89, 7041-7045.
181. SKODA, R.C., SELDIN, D.C., CHIANG, M.K., PEICHEL, C.L., VOGT, T.F., and LEDER, P. (1993). Murine c-mlp: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J. 12, 2645-2653.
182. IP, N.Y., NYE, S.H., BOULTON, T.G., DAVIS, S., TAGA, T., LI, Y., BIRREN, S.J., YASUKAWA, K., KISHIMOTO, T., ANDERSON, D.J., STAHL, N., and YANCOPOULOS, G.D. (1992). CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gpl30. Cell 69, 1121-1132.
183. TAKEUCHI, Y., SATOW, Y., NAKAMURA, K.T., and MITSUI, Y. (1991). Refined crystal structure of the complex of sub-tilisin BPN and Streptomyces subtilisin inhibitor at 1.8 A resolution. J. Mol. Biol. 221, 309-325.
184. MOGENSEN, K.E., BANDU, M.-T., VIGNAUX, F., UZÉ, G., and EID, P. (1984). Receptor-mediated pathways for interferon action: in vivo implications. Med. Oncol. Tumor Pharmaco-ther. 1, 77-85.
185. TANAKA, M., MAEDA, K., OKUBO, T., and NAKASHIMA, K. (1992). Double antenna structure of chicken prolactin receptor deduced from the cDNA sequence. Biochem. Biophys. Res. Commun. 188, 490-496.
186. LEMESLE-VARLOT, L., HENRISSAT, B., GABORIAUD, C., BISSERY, V., MORGAT, A., and MORNON, J.P. (1990). Hydrophobic cluster analysis: procedures to derive structural and functional information from 2-D-representation of protein sequences. Biochimie 72, 555-574.
187. TAYLOR, W.R. (1986). The classification of amino-acid conservation. J. Theor. Biol. 119, 205-215.
188. YASUDA, A., KAWAUCHI, H., and PAPKOFF, H. (1990). The complete amino acid sequence of prolactin from turtle (Che-loniamydas). Gen. Comp. Endocrinol. 80, 363-371.
189. NOSO, T., NICOLL, C.S., and KAWAUCHI, H. (1993). Lung-fish prolactin exhibits close tetrapod relationships. Biochim. Biophys. Acta 1164, 159-165.