SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 5, Issue 8, 1995, Pages 853-856

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

(8) Adachi, Kunitomo a Kohara, Toshiyuki a Nakao, Noriyoshi a Arita, Masafumi a Chiba, Kenji a Mishina, Tadashi d Sasaki, Shigeo b Fujita, Tetsuro c

a Yoshitomi Pharmaceutical Industries Ltd (Japan)

b Research Laboratory (Japan)

c KYOTO UNIVERSITY (Japan)

d NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 TETRADECYL 1,3 PROPANEDIOL; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; PROPANEDIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; GRAFT REJECTION; IMMUNOSUPPRESSIVE TREATMENT; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; RAT; SKIN TRANSPLANTATION;

ANIMALIA;

EID: 0028943870 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/0960-894X(95)00127-F Document Type: Article

Times cited : (280)

References (18)

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- Fujita, T.; Yoneta, M.; Hirose, R.; Sasaki, S.; Inoue, K.; Kiuchi, M.; Hirase, S.; Adachi, K.; Arita, M.; Chiba, K. BioMed. Chem. Lett., preceding communication of this issue.

2
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3
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- When intraperitoneally administrated in the rat skin allograft, 1b displayed intenser local irritation than 1a.

4
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5
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- Fujita¹ Inoue² Yamamoto³ Ikumoto⁴ Sasaki⁵ Toyama⁶ Chiba⁷ Hoshino⁸ Okumoto⁹

7
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- 50=2.9 nM).

8
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- 1.

9
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- The term “toxic” used here means that animals die at indicated doses.

10
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- Mechanism of action:
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- Schreiber¹

11
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13
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14
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15
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- Our study on mechanism of action of FTY720 (2c) will be reported in due course.

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