Ketamine activates psychosis and alters limbic blood flow in schizophrenia

NeuroReport

Volumn 6, Issue 6, 1995, Pages 869-872

  Lahti, Adrienne C ^a   Holcomb, Henry H ^a   Medoff, Deborah R ^a   Tamminga, Carol A ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

Cerebral blood flow; Cingulate; Glutamate; Hippocampus; Ketamine; Psychosis; Schizophrenia

Indexed keywords

HALOPERIDOL; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ARTICLE; BRAIN BLOOD FLOW; CINGULATE GYRUS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; VISUAL CORTEX;

BEHAVIOR; BRAIN CHEMISTRY; CEREBROVASCULAR CIRCULATION; HUMANS; KETAMINE; LIMBIC SYSTEM; MAGNETIC RESONANCE IMAGING; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0028943849     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/00001756-199504190-00011     Document Type: Article

References (24)

1. Carpenter WT and Buchanan RW. New England J Med 330, 681-690 (1994).
2. Carlsson A. Neuropsychopharmacology 1, 179-186 (1988).
3. Pearlson GD. Johns Hopkins Med J 148, 29-33 (1981).
4. Anis NA, Berry SC, Burton NR et al. Br J Pharmacol 79, 5654-5675 (1983).
5. Grnas J and CGS 9755 Study Group. Stroke 25, 12 (1994).
6. Kim JS, Kornhuber HH, Schmid-Beugk W et al. Neurosci Lett 20, 379-382 (1980).
7. Harrison PJ, McLaughlin D and Kerwin RW. Lancet 337,450-452 (1991).
8. Korpi ER, Kaufmann CA, Marnela KM et al. Psychiat Res 20, 337-345 (1987).
9. White PF, Way WL and Trevor AJ. Anesthesiology 56,119-136 (1982).
10. Palfreyman, Reynolds IJ and Skolnick P. Direct and Allosteric Control of Glutamate Receptors. Florida: CRC Press, 1994.
11. Krystal JH, Karper LP, Seibyl JP et al. Arch Gen Psychiatry 51, 199-214 (1994).
12. Tamminga CA, Schaffer MH, Smith RC et al. Science 200, 567-568 (1978).
13. Tamminga CA, Thaker GK, Buchanan R et al. Arch Gen Psychiatry 49,522-530 (1992).
14. Herscovitch P, Markham J and Raichle ME. J Nucl Med 24, 782-789 (1983).
15. Woods RP, Cherry SR, Mazziotta JC. J Comput Assist Tomogr 16, 620-633 (1992).
16. Friston KJ, Frith CD, Liddle PF et al. J Cerebr Blood Flow Metab 11, 690-699 (1991).
17. Friston KJ, Frith CD, Liddle PF et al. J Comput Assist Tomogr 15, 634-639 (1991).
18. Friston KJ, Worsley KJ, Frackowiak RSJ et al. Hum Brain Map 1, 210-220 (1994).
19. Falkai P and Bogerts B. EurArch Psychiat Neurol Sci 236, 154-161 (1986).
20. Suddath RL, Christison GW, Torrey EF et al. N Engl J Med 322, 789-794 (1990).
21. Lahti AC, Koffel B, LaPorte D et al. Neuropsychopharmology. In press.
22. Carlsson M and Carlsson A. J Neural Transm 75, 221-226 (1989).
23. Olney JW, Labruyer J, Wang G et al. Science 254, 1515-1518 (1991).
24. Tamminga CA, Gao XM and Lahti AC. Schizophrenia—An Integrated View. Copenhagen: Munksgaard, 1994.