Serum soluble markers of immune activation and disease activity in systemic lupus erythematosus

Lupus

Volumn 4, Issue 1, 1995, Pages 29-32

  Samsonov, Mikhail Y ^a   Nassonov, Eugeney L ^a   Tilz, Gernot P ^b   Egorova, Olga ^c   Balabanova, Rimma m ^c   Nassonova, Valentina a ^c   Reibnegger, Gilbert ^d   Wachter, Helmut ^d   Fuchs, Dietmar ^d  

^a INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

^b UNIVERSITY OF GRAZ   (Austria)

^c V A NASONOVA RESEARCH INSTITUTE OF RHEUMATOLOGY   (Russian Federation)

^d UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Disease activity; Neopterin; Soluble interleukin 2 receptor; Soluble tumor necrosis factor receptor; Systemic lupus erythematosus

Indexed keywords

BETA 2 MICROGLOBULIN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR; MARKER; NEOPTERIN; TUMOR NECROSIS FACTOR RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; BLOOD LEVEL; CLINICAL TRIAL; DIAGNOSTIC VALUE; DISEASE ACTIVITY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; MACROPHAGE ACTIVATION; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; REGRESSION ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION;

ADOLESCENT; ADULT; ANTIGENS, CD; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; BIOPTERIN; FEMALE; HUMAN; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGE; NEOPTERIN; RECEPTORS, INTERLEUKIN-2; RECEPTORS, TUMOR NECROSIS FACTOR; REGRESSION ANALYSIS; SUPPORT, NON-U.S. GOV'T;

EID: 0028943823     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/096120339500400107     Document Type: Article

References (26)

1. Steinberg AD, Klinman DM Pathogenesis of systemic lupus erythematosus. Rheum Dis Clin North Am 1989; 14: 25-29.
2. Linker-Israeli M., Deans RJ, Wallace DJ, Prehn J., Ozeri-Chen T., Klinenberg JR Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J Immunol 1991; 147: 117-23.
3. Linker-Israeli M. Cytokines abnormalities in human lupus. Clin Immunol Immunopathol 1992; 63: 10-12.
4. Linker-Israeli M., Wallace DJ, Jordan SC, Klinenberg JR Demonstration of IL-1, IL-6 and IFN gamma in SLE kidney biopsies. Arthritis Rheum 1991; 34 (Suppl.): R20 (abstract).
5. Hooks JJ, Jordan GW, Cupps T., Moutsopoulos HM, Fauci AS, Notkins AL Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis. Arthritis Rheum 1982; 25: 396-400.
6. Vitali C., Bencivelli W., Ienberg DA Disease activity in systemic lupus erythematosus: report of the Consensus Study Group in the European Workshop for Rheumatology Research. II. Identification of the variables of disease activity and their use in the development of an activity score. Clin Exp Rheum 1992; 10: 541-7.
7. Leohirun L., Thuvasethakul P., Sumethkul V., Pholcharoen T., Boonpucknavig V. Urinary neopterin in patients with systemic lupus erythematosus. Clin Chem 1991; 37: 47-50.
8. Lim KL, Abdul-Wahab RA, Hughes J., Brown NS, Powell RJ Is urine neopterin a good indicator of disease activity in patients with systemic lupus erythematosus? Comparison with ESR and C 3 degradation products (C3dg). Br J Rheum 1992; 31: 56 (abstract).
9. Lim K., Atta R., Hughes J., Brown NS, Powell RJ Is urine neopterin a good indicator of disease activity in systemic lupus erythematosus (SLE)? Rev Esp Reumatol 1993; 20 (Suppl. 1): 538 (abstract).
10. Huber C., Batchelor JR, Fuchs D. et al. Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. J Exp Med 1984; 160: 310-16.
11. Fuchs D., Hausen A., Reibnegger G., Werner ER, Dierich MP, Wachter H. Neopterin as a marker for activated cell-mediated immunity: application in HIV infection. Immunol Today 1988; 9: 150-5.
12. Reibnegger G., Aichberger C., Fuchs D. et al. Post-transplant neopterin excretion in renal allograft recipients: a reliable diagnostic aid for acute rejection and a predictive marker of longterm graft survival. Transplantation 1991; 52: 58-63.
13. Reibnegger G., Egg D., Fuchs D. et al. Urinary neopterin reflects clinical activity in patients with rheumatoid arthritis. Arthritis Rheum 1986; 29: 1063-70.
14. Aderka D., Wysenbreek A., Engelmann H. et al. Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus. Arthritis Rheum 1993; 36: 1111-20.
15. Cope AP, Aderka D., Doherty M. et al. Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases. Arthritis Rheum 1992; 35: 1160-9.
16. Roux-Lombard P., Punzi L., Hasler F. et al. Soluble tumor necrosis factor receptors in human inflammatory synovial fluids. Arthritis Rheum 1993; 36: 485-9.
17. Denz H., Orth B., Weiss G. et al. Serum soluble tumor necrosis factor receptor 55 is increased in patients with hematological neoplasias and is associated with immune activation and weight-loss. Eur J Cancer 1993; 29A, 2232-5.
18. Zangerle R., Gallati H., Sarcletti M. et al. Increased serum concentrations of soluble tumor necrosis factor receptors in HIV-infected individuals are associated with immune activation. J Acquir Immune Defic Syndr 1994; 7: 75-80.
19. Wolf RE, Brelstord WG Soluble interleukin-2 receptors in systemic lupus erythematosus. Arthritis Rheum 1988; 31: 729-35.
20. Tomkinson BE, Brown MC, Ip SH, Carrabis S., Sullivan JL Soluble CD8 during T cell activation. J Immunol 1989; 142: 2230-6.
21. Linker-Israeli M., Hyun S., Wallace DJ, Klinberg JR Soluble CD8 molecules in systemic lupus erythematosus (SLE). Rev Esp Reumatol 1993; 20 (Suppl. 1): 420 (abstract).
22. Creswell P., Springer T., Strominger JL, Turner MJ, Grey HM, Kubo RT Immunological identity of the small subunit of HLA-A and beta-2-microglobulin and its turnover on the cell membrane. Proc Natl Acad Sci USA 1974; 71: 2123-7.
23. Fuchs D., Krämer A., Reibnegger G. et al. Neopterin and β2-microglobulin as prognostic indices in human immunodeficiency virus type I infection. Infection 1991; 19 (Suppl. 2): S98-S102.
24. Fuchs D., Hausen A., Reibnegger G. et al. Immune activation and the anaemia associated with chronic inflammatory disorders. Eur J Haematol 1991; 46: 65-70.
25. Samsonov M., Reibnegger G., Nassonov E., Nassonova V., Wachter H., Fuchs D. Elevated serum neopterin levels in acute rheumatic fever. Pteridines 1993; 4: 39-42.
26. Fuchs D., Zangerle R., Artner-Dworzak E. et al. Association between immune activation, changes of iron metabolism and anaemia in patients with HIV infection. Eur J Haematol 1993; 50: 90-94.