Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss

Molecular Brain Research

Volumn 29, Issue 1, 1995, Pages 1-14

  Beilharz, Erica J ^a   Williams, Chris E ^a   Dragunow, Mike ^a   Sirimanne, Ernest S ^a   Gluckman, Peter D ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Apoptosis; DNA ladder; Hypoxia ischemia; Infarction; Microglial activation; Necrosis; Selective neuronal death

Indexed keywords

FUCHSINE; LECTIN; TRIPHENYLTETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL STRUCTURE; CONTROLLED STUDY; DNA DEGRADATION; ELECTROPHORESIS; HISTOCHEMISTRY; MICROGLIA; MITOCHONDRION; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ANIMALS, NEWBORN; ANOXIA; APOPTOSIS; BRAIN ISCHEMIA; CELL DEATH; DEOXYRIBONUCLEASES; MICROGLIA; MITOCHONDRIA; NEURONS; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; TIME FACTORS;

ANIMALIA;

EID: 0028941909     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-328X(94)00217-3     Document Type: Article

References (54)

1. Disturbance of a mitochondrial DNA expression in gerbil hippocampus after transient forebrain ischemia
2. Enhanced calcium uptake by CA1 pyramidal cell dendrites in the postischemic phase despite subnormal evoked field potentials: excitatory amino acid receptor dependency and relationship to neuronal damage
3. Changes in extracellular amino acids and spontaneous neuronal activity during ischemia and extended reflow in the CA1 of the rat hippocampus
4. The temporal evolution of hypoglycemic brain damage. II. Light- and electron-microscopic findings in the hippocarnpal gyrus and subiculum of the rat
5. Does oligodendrocyte survival depend on axons?
6. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats
7. Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis
8. Selective neuronal death after transient forebrain ischemia in the mongolian Gerbil: a silver impregnation study
9. Ultrastructural changes in the hippocampul CA1-region following transient cerebral ischemia — evidence against programmed cell death
10. Immediate-early gene protein expression in neurons undergoing delayed death but not necrosis following hypoxic-ischemic injury to the young rat brain
11. Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury
12. Apoptosis: a product of programmed and unprogrammed cell death
13. Neuronal toxicity by macrophages in mixed brain cell culture is augmented by antineuronal IgG and dependent upon nitric oxide synthesis
14. Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma 7777 tissue: apoptosis or necrosis?
15. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
16. Immunocytochemical study of an early microglial activation in ischemia
17. The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain
18. Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord
19. Brain glia release factors with opposing actions upon neuronal survival
20. When and why do brain cells die?
21. Combined oxygen and glucose deprivation in cortical cell culture — calcium-dependent and calcium-independent mechanisms of neuronal injury
22. Effects of cycloheximide on delayed neuronal death in rat hippocampus
23. The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats
24. Effects of hypoxia-ischemia and seizures on neuronal and gliallike c-fos protein levels in the infant rat
25. Regional variability in DNA fragmentation after global ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain
26. Le(y) antigen expression is correlated with apoptosis (programmed cell death)
27. Apoptosis
28. Delayed neuronal death in the gerbil hippocampus following ischemia
29. 1 mRNA in the infant rat brain
30. Glutamate triggers internucleosomal DNA cleavage in neuronal cells
31. Macrophages are required for cell death and tissue remodeling in the developing mouse eye
32. The possible contribution of microglia and macrophages to delayed neuronal dealh after ischemia
33. The microglial reaction in the dorsal hippocampus following transient forebrain ischemia
34. Characterization of microglial reaction after middle cerebral artery occlusion in rat brain
35. Apoptosis of human erythroid colony-forming cells is decreased by stem cell factor and insulin-like growth factor-1 as well as erythropoietin
36. Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced
37. Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate
38. Temporal profile of neuronal damage in a model of transient forebrain ischemia
39. Social controls on cell survival and cell death
40. Aurintricarboxylic acid protects hippocampal neurons from NMDA-induced and ischemia-induced toxcicity invivo
41. Insulin like-growth factor-1 inhibits apoptosis in IL-3-dependent hemopoietic cells
42. Aurintricarboxylic acid protects hippocampal neurons from glutamate excitotoxicity invitro
43. Reduction of delayed neuronal death by inhibition of protein synthesis
44. Two models for determining the mechanisms of damage and repair after hypoxic-ischemic injury in the developing rat brain
45. Electron microscopic analysis of ad renalectomy-induced hippocampal granule cell degeneration in the rat: apoptosis in the adult central nervous system
46. Morphological lesions in the brain preceding the development of postischemic seizures
47. Suppression of postischemic epileptiform activity with MK-801 improves neural outcome in fetal sheep
48. Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro
49. Cytotoxic effect of brain macrophages on developing neurons
50. Endonuclease activation following focal ischemic injury in the rat brain
51. Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages
52. Time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep
53. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
54. Aurintricarboxylic acid prevents NMDA-mediated excitotoxicity — evidence for its action as an NMDA receptor antagonist