Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides

Proceedings of the National Academy of Sciences of the United States of America

Volumn 92, Issue 6, 1995, Pages 2398-2402

  Shirasaka, Takuma ^a   Kavlick, Mark F ^a   Ueno, Takamasa ^a   Gao, Wen Yi ^a   Kojima, Eiji ^a   Alcaide, Maria L ^a   Chokekijchai, Sudhichai ^a   Roy, Birgit M ^b   Arnold, Edward ^b   Yarchoan, Robert ^a   Mitsuya, Hiroaki ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

dNTP binding site; multidrug resistance; reverse transcriptase

Indexed keywords

DIDANOSINE; RNA DIRECTED DNA POLYMERASE; VIRUS RNA; ZALCITABINE; ZIDOVUDINE;

ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIREMIA; VIRUS MUTANT; VIRUS MUTATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AMINO ACID SEQUENCE; BASE SEQUENCE; CLONING, MOLECULAR; COMPARATIVE STUDY; DIDEOXYNUCLEOSIDES; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; GENES, POL; GENOTYPE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMAN; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; RNA-DIRECTED DNA POLYMERASE; SUPPORT, U.S. GOV'T, P.H.S.; TEMPLATES, GENETIC; TRANSFECTION; VARIATION (GENETICS);

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0028940084     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.92.6.2398     Document Type: Article

References (30)