Apoptosis in HIV infection

Nature Medicine

Volumn 1, Issue 2, 1995, Pages 118-120

  Pantaleo, Giuseppe ^a   Fauci, Anthony S ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DNA FRAGMENT; GLYCOPROTEIN GP 120; VIRUS RNA;

APOPTOSIS; CYTOPATHOGENIC EFFECT; ETIOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; IN SITU HYBRIDIZATION; LYMPHOCYTE ACTIVATION; NOTE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIRUS EXPRESSION;

APOPTOSIS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HIV INFECTIONS; HIV-1; HUMAN; SIV;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0028939951     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm0295-118     Document Type: Article

References (16)

1. Terai, C, Kombluth, R.S., Pauza, CD., Richman, D.D. & Carson, D.A. Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1, J. clin. invest 87, 1710-1715 (1991).
2. Laurent-Crawford, A.G., Krust, B. & Muller, S. The cytopathic effect of HIV is associated with apoptosis. Virology 185, 829-839 (1991).
3. Ameisen, J.C. & Capron, A. Cell dysfunction and depletion in AIDS: The programmed cell death hypothesis. Immunol. Today 12, 102-105 (1991).
4. Gougeon, M.L. et al. Mise en evidence d'un processus d'engagment vers la mort cellulaire par apoptose dans les lymphocytes de patients infectes par le VIH. C. R. Acad. Sci. Paris Ser II Sci. Vie 312, 529-537 (1991).
5. Meyaard, L. et al. Programmed death of T cells in HIV-1 infection. Science 257, 217-219 (1992).
6. Banda, N.K. et al. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med 176, 1099-1106(1992).
7. Finkel, T.H. et al. Apoptosis occurs predominantlyon bystander cells and not in productively infected cells of HIV-and SIV-infected Lymph nodes. Nature Med. 1, 129-134 (1995)
8. Pantaleo, G. et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362, 355-359 (1993).
9. Embretson, J. et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362, 359-362 (1993).
10. Meyaard, L. et al. J. clin. Invest. 93, 982 (1994).
11. Pantaleo, G. et al. Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol. Rev. 140, 105-130 (1994).
12. Cohen, J.J. et al. Ann. Rev. Immunol. (1992).
13. Lenardo, M.J. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353, 858-861 (1991).
14. Wesselborg, S., Janssen, O. & Kabelitz, D. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells. J. Immunol. 150, 4338-4345 (1993).
15. Ascher, M.S. & Sheppard, H.W. AIDS as immune system activation. II. The Panergic Imnesia Hypothesis. J. AIDS 3, 177-191 (1990).
16. Pantaleo, G. & Fauci, A.S. Tracking HIV during disease progression. Curr. Opin. Immunol, 6, 600-604 (1994).