-
1
-
-
0027535559
-
Towards an understanding of the molecular mechanisms of physiological cell death
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edn 2
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 786-789
-
-
Vaux1
-
2
-
-
0028040019
-
Bcl-2 and the regulation of programmed cell death
-
(1994)
J Cell Biol
, vol.124
, pp. 1-6
-
-
Reed1
-
6
-
-
0027511687
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Programmed cell' death induced by ceramide
-
of outstanding interest, The first paper linking this new signalling system to cell death. TNFα receptor stimulation leads to a transient drop in sphingomyelin and rise in its cleavage product ceramide. Ceramide itself can initiate apoptosis.
-
(1993)
Science
, vol.259
, pp. 1769-1771
-
-
Obeid1
Linardic2
Karolak3
Hannun4
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11
-
-
0028001530
-
Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death
-
of special interest, A striking contrast is drawn between APO-1/Fas and TNF receptor mediated signalling in the same cell type.
-
(1994)
EMBO J
, vol.13
, pp. 4587-4596
-
-
Schultze-Osthoff1
Krammer2
Droge3
-
12
-
-
0027145632
-
Molecular cloning and expression of the Fas ligand, a novel member of the tumour necrosis factor family
-
of outstanding interest, A brilliant combination of molecular biological and cell biological strategies. A cytotoxic T-cell hybridoma was subcloned to select variants in which perforin-mediated killing was absent, but Fas-mediated killing retained. After a futher subcloning to achieve high expression, a cDNA expression library was made and transfected into COS cells, and producers were isolated by panning on plates coated with a Fas chimaeric protein.
-
(1993)
Cell
, vol.75
, pp. 1169-1178
-
-
Suda1
Takahashi2
Golstein3
Nagata4
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13
-
-
0028097822
-
Purification and characterisation of the fas ligand that induces apoptosis
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(1994)
J Exp Med
, vol.179
, pp. 873-879
-
-
Suda1
Nagata2
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14
-
-
0028274042
-
Protection from fas-mediated apoptosis by a soluble form of the fas molecule
-
of special interest, An observation of great potential clinical importance. Some patients with systemic lupus erythematosus have a circulating Fas molecule that might function by blocking the physiological Fas ligand.
-
(1994)
Science
, vol.263
, pp. 1759-1762
-
-
Cheng1
Zhon2
Liu3
Shapiro4
Brauer5
Kiefer6
Barr7
Mountz8
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18
-
-
0027364326
-
The c-myc protein induces cell cycle progression and apoptosis through dimerization with max
-
of special interest, Elegant demonstration that Myc-Max dimers are essential for myc action. Mutations that prevent dimer formation inhibit myc function, but double mutants that permit dimer formation are functional.
-
(1993)
EMBO J
, vol.12
, pp. 5083-5087
-
-
Amati1
Littlewood2
Evan3
Land4
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19
-
-
0027934570
-
p53-dependent apoptosis produced by Rb deficiency in the developing mouse lens
-
of special interest, This interesting finding could be the first clear description of apoptosis coupled to p53 in the absence of DNA damage. However, nuclease activation occurs as part of normal lens differentiation, and it is possible that p53 expression in lens development is linked to that.
-
(1994)
Nature
, vol.371
, pp. 72-74
-
-
Morgenbesser1
Williams2
Jacks3
DePinho4
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21
-
-
0028222124
-
p53 and E2F cooperate to mediate apoptosis
-
of special interest, edn 2, The Rb-binding transcriptional activator E2F-1 causes apoptosis on ectopic expression coincident with p53 in fibroblasts.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3602-3606
-
-
Wu1
Levine2
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23
-
-
0027262606
-
Stabilisation of the p53 tumor suppressor is induced by adenovirus 5E1A and accompanies apoptosis
-
(1993)
Genes Dev
, vol.7
, pp. 535-545
-
-
Lowe1
Ruley2
-
24
-
-
0027251720
-
Wild type p53 mediates apoptosis by E1A which is inhibited by E1B
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(1993)
Genes Dev
, vol.7
, pp. 546-554
-
-
Debbas1
White2
-
25
-
-
0028299320
-
Induction of apoptosis by adenovirus type 5E1A in rat cells requires a proliferation block
-
(1994)
Oncogene
, vol.9
, pp. 1187-1193
-
-
Myryk1
Shire2
Bayley3
-
26
-
-
0028171968
-
Mediation of c-myc-induced apoptosis by p53
-
(1994)
Science
, vol.265
, pp. 2091-2092
-
-
Hermeking1
Eick2
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28
-
-
0028301094
-
p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following γ-irradiation
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1 arrest following radiation, but enter apoptosis as their only option in the presence of p53.
-
(1994)
Oncogene
, vol.9
, pp. 1767-1773
-
-
Clarke1
Gledhill2
Hooper3
Bird4
Wyllie5
-
29
-
-
0027451668
-
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
-
of special interest, Using fibroblasts from gene knockout mice and their litter-mate controls, the authors show that the cytotoxicity of a variety of chemotherapeutic agents requires expression of wild-type p53. In these cells, as others have shown (see [24]), apoptosis is also critically dependent upon blockade of Rb, in this case by the adenovirus E1A gene product.
-
(1993)
Cell
, vol.74
, pp. 957-967
-
-
Lowe1
Ruley2
Jacks3
Housman4
-
30
-
-
0028263811
-
c-myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
-
of special interest, Videomicroscopy evidence that c-myc induced apoptosis is inhibited by insulin-like growth factor 1 and epidermal growth factor, but not bombesin.
-
(1994)
EMBO J
, vol.13
, pp. 3286-3295
-
-
Harrington1
Bennett2
Fanidi3
Evan4
-
32
-
-
0028070989
-
p53-dependent apoptosis in the absence of transcriptional activational of p53 target genes
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of special interest, The authors show that cultured cells bearing a temperature-sensitive p53 mutation enter apoptosis following genotoxic stimuli only if the wild-type form of p53 is expressed. This apoptosis is insensitive to cycloheximide and actinomycin D at dosages that suppress the p53-induced protein mdm2. This controversial result may reflect the particular status of the pituitary cell line used.
-
(1994)
Nature
, vol.370
, pp. 220-223
-
-
Caelles1
Helmberg2
Karin3
-
37
-
-
0027436691
-
Cell proliferation, DNA repair and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation
-
of special interest, edn 2, A very careful study demonstrating that apoptosis in this endocrine-dependent tissue is not related to entry to the cell cycle.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 8910-8914
-
-
Berges1
Furuya2
Rennington3
English4
Jacks5
Isaacs6
-
38
-
-
0028275077
-
Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilisation of wild type p53
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(1994)
Mol Cell Biol
, vol.14
, pp. 4183-4192
-
-
Kelley1
Green2
Hicks3
Bondurant4
Koury5
Ruley6
-
39
-
-
0027330973
-
Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by bcl-2
-
of special interest, This paper demonstrates convincing bcl-2 responsive apoptosis in cytokine-sensitive cells under conditions in which c-myc expression is not induced.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 7000-7005
-
-
Vaux1
Weissman2
-
43
-
-
0027515642
-
Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability
-
(1993)
Br J Cancer
, vol.68
, pp. 1127-1133
-
-
Arends1
McGregor2
Toft3
Brown4
Wyllie5
-
44
-
-
0028200532
-
Genetic control of programmed cell death in Drosophilia
-
of outstanding interest, The first description of the Drosophila reaper gene. This important gene facilitates physiological apoptosis in the Drosophila embryo, as well as that induced by radiation.
-
(1994)
Science
, vol.264
, pp. 677-683
-
-
White1
Grether2
Abrams3
Young4
Farrell5
Steller6
-
46
-
-
0028149786
-
Checkpoints of duelling dimers foil death wishes
-
(1994)
Cell
, vol.79
, pp. 189-192
-
-
Oltvai1
Korsmeyer2
-
52
-
-
0027166048
-
bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death
-
of special interest, This paper decribes the cloning of bax, encoding the 21 kDa partner of Bcl-2, indicates the ability of Bax to induce apoptosis by titration versus Bcl-2 and demonstrates by immunoprecipitation the formation of Bax-Bcl-2 heterodimers.
-
(1993)
Cell
, vol.74
, pp. 609-619
-
-
Oltvai1
Milliman2
Korsmeyer3
-
53
-
-
0028288277
-
C. elegans cell survival gene ced 9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
-
of outstanding interest, This paper demonstrates functional as well as structural homology between the mammalian and nematode death pathways.
-
(1994)
Cell
, vol.76
, pp. 665-676
-
-
Hengartner1
Horvitz2
-
54
-
-
0028206341
-
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
-
of special interest, The first description of the molecular basis for the complex dimerization reactions that appear to be involved in the regulation of death by the Bcl-2 system.
-
(1994)
Nature
, vol.369
, pp. 321-323
-
-
Yin1
Oltvai2
Korsmeyer3
-
56
-
-
0027261321
-
Suppressionof apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors
-
of special interest, A particularly clear demonstration that Bcl-2 can suppress apoptosis without influencing cell division.
-
(1993)
Cell
, vol.74
, pp. 823-832
-
-
Fairbaim1
Cowling2
Reipert3
Dexter4
-
58
-
-
0027717968
-
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species
-
of special interest, Not all the death described in this paper would be regarded by morphologists as apoptosis, but Bcl-2 affords protection nonetheless. This result has very substantial implications for clinical science.
-
(1993)
Science
, vol.262
, pp. 1274-1277
-
-
Kane1
Sarafian2
Anton3
Hahn4
Gralla5
Valentine6
Ord7
Bredesen8
-
59
-
-
0027427492
-
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys and hypopigmented hair
-
of special interest, Perhaps surprisingly, these knockout mice appear normal at birth, but die early. Collapse of the immune system occurs during antigenic stimulation at an inconstant time after birth.
-
(1993)
Cell
, vol.75
, pp. 229-240
-
-
Veis1
Sorenson2
Shutter3
Korsmeyer4
-
61
-
-
0028113218
-
Adenovirus E1B 19kDa and Bcl-2 proteins interact with a common set of cellular proteins
-
of special interest, Probably the first of many studies on protein-protein interactions in cell death. Yeast two-hybrid analysis identified three cellular proteins that interact both with the E1B 19 kDa protein and Bcl-2, apparently through regions of amino acid sequence that are similar in both.
-
(1994)
Cell
, vol.79
, pp. 341-352
-
-
Boyd1
Malstrom2
Subramian3
Venkatesh4
Schaerer5
Elangovan6
D'sa-Eipper7
Chinnadurai8
-
65
-
-
0028238213
-
Immediate early up-regulation of bax expression by p53 but not TGFβ1: a paradigm for distinct apoptotic pathways
-
of special interest, An unexpected link between the p53 and Bcl-2 systems. In a myeloid cell line, p53 up-regulates expression of bax mRNA by an immediate early cycloheximide-insensitive mechanism.
-
(1994)
Oncogene
, vol.9
, pp. 1791-1798
-
-
Selvakumaran1
Lin2
Miyashita3
Wang4
Krajewski5
Reed6
Hoffman7
Lieberman8
-
66
-
-
0027525104
-
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
-
••] annotation
-
(1993)
Cell
, vol.75
, pp. 641-652
-
-
Yuan1
Shaham2
Ledoux3
Ellis4
Horvitz5
-
67
-
-
0028168593
-
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
-
••] annotation
-
(1994)
Cell
, vol.78
, pp. 739-750
-
-
Wang1
Miuru2
Bergeron3
Zhu4
Yuan5
-
68
-
-
0027990778
-
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.
-
••,67••] forge the formal link between the effector cysteine proteases of nematode and mammalian cell death.
-
(1994)
Genes & Development
, vol.8
, pp. 1613-1626
-
-
Kumar1
Kinoshita2
Noda3
Copeland4
Jenkins5
-
69
-
-
0028102478
-
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
-
of special interest, Provocative results from a cell-free system (described in full in an earlier paper). The authors argue that cleavage of poly(ADP-ribose) polymerase at the ICE-sensitive site between the DNA-binding and catalytic domains may be part of a strategy to prevent DNA repair in apoptosis.
-
(1994)
Nature
, vol.371
, pp. 346-347
-
-
Lazebnik1
Kaufmann2
Desnoyers3
Poirier4
Earnshaw5
-
70
-
-
0028019746
-
Cell-free apoptosis in Xenopus egg extracts: inhibition by bcl-2 and requirement for an organelle function in mitochondria
-
of special interest, A second exciting cell-free system. The protease has not yet been definitively identified. The pre-incubation period required for its activation may represent initiation of a catalytic cascade.
-
(1994)
Cell
, vol.79
, pp. 353-364
-
-
Newmeyer1
Farschon2
Reed3
-
72
-
-
0027431380
-
Different rates of degradation of the proliferation-associated nuclear and nucleolar antigens during apoptosis of HL-60 cells induced by DNA topoisomerase inhibitors
-
(1993)
Int J Oncol
, vol.3
, pp. 627-634
-
-
Gorczyca1
Ardelt2
Darzynkiewicz3
-
73
-
-
0026474805
-
Purification of three cytotoxic lymphocyte serine proteases that induce apoptosis through distinct substrate and target cell interactions
-
(1992)
J Exp Med
, vol.176
, pp. 1521-1529
-
-
Shi1
Kam2
Powers3
Aebersold4
Greenberg5
-
76
-
-
0028175797
-
2+-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis
-
(1994)
J Biol Chem
, vol.269
, pp. 14857-14860
-
-
Sun1
Cohen2
-
78
-
-
0028334011
-
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development
-
•] annotation
-
(1994)
Genes Dev
, vol.8
, pp. 1285-1299
-
-
Pan1
Griep2
-
80
-
-
0028226679
-
Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.
-
of special interest, This paper and [78',79'1 show in vivo what had been strongly established in cultured cells in vitro-although disabling rb-1 leads to a 'high turnover' state in which replication and apoptosis continue together, removal of functional p53 in tandem produces tumour growth.
-
(1994)
Molecular and Cellular Biology
, vol.14
, pp. 2686-2698
-
-
Saenz-Robles1
Symonds2
Chen3
van Dyke4
-
81
-
-
0028331229
-
Differential disruptions of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins
-
of outstanding interest, These experiments relate Rb-1 (and related HPV 16 E7 binding proteins) and p53 to the patterns of genomic instability seen in the cells that escape death following negative growth signals. Much of this death appears to be apoptosis, and the experiments afford one of the few quantitative insights into the issue of whether the founder cells of neoplasms are cells that have escaped death.
-
(1994)
Genes Dev
, vol.8
, pp. 666-677
-
-
White1
Livanos2
Tlsty3
-
83
-
-
0028072523
-
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by bcl-2
-
2-arrested population.
-
(1994)
Cell
, vol.79
, pp. 329-340
-
-
Strasser1
Harris2
Jacks3
Cory4
-
86
-
-
0027327511
-
Latent membrane protein of Epstein-Barr virus induces cellullar phenotypes independently of expression of Bcl-2
-
(1993)
J Vrol
, vol.67
, pp. 5269-5278
-
-
Martin1
Veis2
Korsmeyer3
Sugden4
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