Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases

Journal of the National Cancer Institute

Volumn 87, Issue 4, 1995, Pages 293-298

  Taraboletti, Giulia ^a   Garofalo, Angela ^a   Belotti, Dorina ^a   Drudis, Teresa ^a   Borsotti, Patrizia ^a   Scanziani, Eugenio ^b   Brown, Peter D ^c   Giavazzi, Raffaella ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c British Biotech Pharmaceuticals Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

[4 (N HYDROXYAMINO) 2 ISOBUTYL 3 (2 THIENYLTHIOMETHYL)SUCCINYL]PHENYLALANINAMIDE; AMIDE; BATIMASTAT; BB 374; METALLOPROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ADOLESCENT; ANGIOGENESIS; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG EFFECT; HEMANGIOMA; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; NUDE MOUSE; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR GROWTH;

ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEMANGIOENDOTHELIOMA; METALLOENDOPEPTIDASES; MICE; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; PHENYLALANINE; SUPPORT, NON-U.S. GOV'T; THIOPHENES; TIME FACTORS;

EID: 0028939303     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/87.4.293     Document Type: Article

References (30)

1. Enzinger F: Benign tumors and tumor-like lesions of blood vessels. In Soft Tissue Tumors. St. Louis: Mosby, 1983, pp 379-422
2. Ezekowitz RA, Mulliken JB, Folkman J: Interferon alfa-2a therapy for life-threatening hemangiomas of infancy [see comment citations in Medline]. N Engl J Med 326:1456-1463, 1992
3. Levine AM: AIDS-related malignancies: the emerging epidemic. J Natl Cancer Inst 85:1382-1387,1993
4. Thompson EW, Nakamura S, Shima TB, et al: Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness. Cancer Res 51:2670-2676, 1991
5. Salahuddin SZ, Nakamura S, Biberfeld P, et al: Angiogenic properties of Kaposi’s sarcoma-derived cells after long-term culture in vitro. Science 242:430-433, 1988
6. Williams RL, Courtneidge SA, Wagner EF: Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middleToncogene. Cell 52:121-131, 1988
7. Williams RL, Risau W, Zerwes HG, et al: Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell 57:1053-1063, 1989
8. Garlanda C, Parravicini C, Sironi M, et al: Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle T: implications for the pathogenesis of opportunistic vascular tumors. Proc Natl Acad Sci U S A 91:7291-7295, 1994
9. Taraboletti G, Belotti D, Dejana E, et al: Endothelial cell migration and invasiveness are induced by a soluble factor produced by murine endothelioma cells transformed by polyoma virus middle T oncogene. Cancer Res 53:3812-3816,1993
10. Mignatti P, Tsuboi R, Robbins E, et al: In vitro angiogenesis on the human ammotic membrane: requirement for basic fibroblast growth factor-induced proteinases. I Cell Biol 108:671-682,1989
11. Unemon EN, Ferrara N, Bauer EA, et al Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 153:557-562, 1992
12. Brown PD: Matrix metalloproteinase inhibitors: a new class of anticancer drugs. Curr Opin Invest Drugs 2:617-626, 1993
13. Zoja C, Orisio S, Perico N, et al: Constitutive expression of endothelin gene in cultured human mesangial cells and its modulation by transforming growth factor-beta, thrombin, and a thromboxane A2 analogue. Lab Invest 64:16-20, 1991
14. Passamti A, Taylor RM, Pill R, et al: A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 67:519-528, 1992
15. Chirivi RG, Garofalo A, Crimmin MJ, et al: Inhibition of the metastatic spread and growth of BI6-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor. Int J Cancer 58:460-464, 1994
16. Mann HB, Whitney DR: On a test of whether one of two random variables is stochastically larger than the other. Ann Math Stat 18:50-60, 1947
17. Davies B, Brown PD, East N, et al: A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts [published erratum appears in Cancer Res 53:3652, 1993], Cancer Res 53:2087-2091,1993
18. Murphy AN, Unsworth EJ, Stetler-Stevenson WG: Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation. J Cell Physiol 157:351-358,1993
19. Schnaper HW, Grant DS, Stetler-Stevenson WG, et al: Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro. J Cell Physiol 156:235-246, 1993
20. Montesano R, Pepper MS, Mbhle-Steinlein U, et al: Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell 62:435-445, 1990
21. Mignatti P, Robbins E, Rifkin DB: Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade Cell 47:487-498, 1986
22. Schultz RM, Silberman S, Persky B, et al: Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells. Cancer Res 48:5539-5545, 1988
23. Alvarez OA, Carmichael DF, DeClerck YA: Inhibition of collagenolytic activity and metastasis of tumor cells by a recombinant human tissue inhibitor of metalloproteinases. J Natl Cancer Inst 82.589-595, 1990
24. Albini A, Melchion A, Santi L, et al: Tumor cell invasion inhibited by TIMP-2 [see comment citation in Medline], J Natl Cancer Inst 83:775-779, 1991
25. Khokha R, Zimmer MJ, Graham CH, et al: Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in B16-F10 melanoma cells. J Natl Cancer Inst 84:1017-1022, 1992
26. Khokha R, Waterhouse P, Yagel S, et al: Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells. Science 243:947-950, 1989
27. Khokha R: Suppression of the tumorigenic and metastatic abilities of murine BI6-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1. J Natl Cancer Inst 86:299-304, 1994
28. DeClerck YA, Perez N, Shimada H, et al: Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases. Cancer Res 52:701-708, 1992
29. Moses MA, Sudhalter J, Langer R: Identification of an inhibitor of neovascularization from cartilage. Science 248:1408-1410, 1990
30. Takigawa M, Nishida Y, Suzuki F, et al: Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2). Biochem Biophys Res Commun 171:1264-1271,1990