메뉴 건너뛰기




Volumn 55, Issue 5, 1995, Pages 1070-1074

Idoxifene: Report of a Phase I Study in Patients with Metastatic Breast Cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; IDOXIFENE; TAMOXIFEN;

EID: 0028935148     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (80)

References (34)
  • 2
    • 0020516248 scopus 로고
    • Antiestrogenic effects of LY117018 in MCF-7 cells
    • Scholl, S. M., Huff, K. K., and Lippman, M. E. Antiestrogenic effects of LY117018 in MCF-7 cells. Endocrinology, 113: 611, 1983.
    • (1983) Endocrinology , vol.113 , pp. 611
    • Scholl, S.M.1    Huff, K.K.2    Lippman, M.E.3
  • 3
    • 0002844490 scopus 로고
    • The first non-steroidal antiestrogen—MER 25
    • R. C. Sutherland and V. C. Jordan (eds.) Sidney, Australia: Sydney Academic Press
    • Lerner, L. J. The first non-steroidal antiestrogen—MER 25. In: R. C. Sutherland and V. C. Jordan (eds.), Non-steroidal Antiestrogens, pp 1–16. Sidney, Australia: Sydney Academic Press, 1981.
    • (1981) Non-steroidal Antiestrogens , pp. 1-16
    • Lerner, L.J.1
  • 5
    • 0026395885 scopus 로고
    • A potent specific pure anti-estrogen with clinical potential
    • Wakeling, A. E., Dukes, M., and Bowler, J. A potent specific pure anti-estrogen with clinical potential. Cancer Res., 51: 3867–3873, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 3867-3873
    • Wakeling, A.E.1    Dukes, M.2    Bowler, J.3
  • 8
    • 0026345105 scopus 로고
    • Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen, new analogues of the antiestrogen tamoxifen for the treatment of breast cancer
    • Chander, S. K., McCague, R., Luqmani, Y., Newton, C., Dowsett, M., Jarman, M., and Coombes, R. C. Pyrrolidino-4-iodotamoxifen and 4-iodotamoxifen, new analogues of the antiestrogen tamoxifen for the treatment of breast cancer. Cancer Res., 51: 5851–5858, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 5851-5858
    • Chander, S.K.1    McCague, R.2    Luqmani, Y.3    Newton, C.4    Dowsett, M.5    Jarman, M.6    Coombes, R.C.7
  • 9
    • 0025010197 scopus 로고
    • Metabolism of the 4-iodo derivative of tamoxifen by isolated rat hepatocytes
    • McCague, R., Parr, I. B., and Haynes, B. P. Metabolism of the 4-iodo derivative of tamoxifen by isolated rat hepatocytes. Biochem. Pharmacol., 40: 2277–2283, 1990.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 2277-2283
    • McCague, R.1    Parr, I.B.2    Haynes, B.P.3
  • 10
    • 0026580111 scopus 로고
    • Tamoxifen and the isomers of 4-hydroxy tamoxifen in tamoxifen-resistant tumours from breast cancer patients
    • Osborne, C. K., Wiebe, V. J., and McGuire, W. L. Tamoxifen and the isomers of 4-hydroxy tamoxifen in tamoxifen-resistant tumours from breast cancer patients. J. Clin. Oncol., 10: 304–310, 1992.
    • (1992) J. Clin. Oncol. , vol.10 , pp. 304-310
    • Osborne, C.K.1    Wiebe, V.J.2    McGuire, W.L.3
  • 11
    • 0027280831 scopus 로고
    • Investigation of mechanism of tamoxifen-stimulated breast rumour growth with nonisomerizable analogues of tamoxifen and metabolites
    • Wolf, D. M., Langan-Fahey, M., Parker, C. J., McCague, R., and Jordan, V. C. Investigation of mechanism of tamoxifen-stimulated breast rumour growth with nonisomerizable analogues of tamoxifen and metabolites. J. Natl. Cancer. Inst., 85: 806–812, 1993.
    • (1993) J. Natl. Cancer. Inst. , vol.85 , pp. 806-812
    • Wolf, D.M.1    Langan-Fahey, M.2    Parker, C.J.3    McCague, R.4    Jordan, V.C.5
  • 13
    • 0025277529 scopus 로고
    • Variation of the inhibition of calmodulin dependent cyclic AMP phosphodiesterase amongst analogues of tamoxifen: correlations with cytotoxicity
    • Rowlands, M. G., Parr, I. B., McCague, R., Jarman, M., and Goddard, P. M. Variation of the inhibition of calmodulin dependent cyclic AMP phosphodiesterase amongst analogues of tamoxifen: correlations with cytotoxicity. Biochem. Pharmacol., 40: 283–289, 1990.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 283-289
    • Rowlands, M.G.1    Parr, I.B.2    McCague, R.3    Jarman, M.4    Goddard, P.M.5
  • 14
    • 0022828736 scopus 로고
    • Calmodulin antagonism and growth inhibitory activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells
    • Gulino, A., Barrera, G., Vacca, A., Farina, A., Ferretti, C., Screpanti, I., Diazani, M. V., and Frati, L. Calmodulin antagonism and growth inhibitory activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells. Cancer Res., 46: 6274–6278, 1986.
    • (1986) Cancer Res. , vol.46 , pp. 6274-6278
    • Gulino, A.1    Barrera, G.2    Vacca, A.3    Farina, A.4    Ferretti, C.5    Screpanti, I.6    Diazani, M.V.7    Frati, L.8
  • 15
    • 0023621378 scopus 로고
    • Mechanism of growth inhibition by non-steroidal antioestrogens in human breast cancer cells
    • Sutherland, R. L., Watts, C. K. W., Hall, R. E., and Ruenitz, P. C. Mechanism of growth inhibition by non-steroidal antioestrogens in human breast cancer cells. J. Steroid Biochem. Mol. Biol., 27: 891–897, 1987.
    • (1987) J. Steroid Biochem. Mol. Biol. , vol.27 , pp. 891-897
    • Sutherland, R.L.1    Watts, C.K.W.2    Hall, R.E.3    Ruenitz, P.C.4
  • 16
    • 0007255224 scopus 로고
    • Metabolism and pharmacokinetics of pyrrolidino-4-iodotamoxifen in the rat
    • Haynes, B. P., Parr, I. B., Griggs, L. J., and Jarman, M. Metabolism and pharmacokinetics of pyrrolidino-4-iodotamoxifen in the rat. Breast Cancer Res. Treat., 19: 174, 1991.
    • (1991) Breast Cancer Res. Treat. , vol.19 , pp. 174
    • Haynes, B.P.1    Parr, I.B.2    Griggs, L.J.3    Jarman, M.4
  • 17
    • 0017354838 scopus 로고
    • Recurrent breast cancer treated with the antioestrogen tamoxifen: correlation between hormonal changes and clinical course
    • Willis, K. J., London, D. R., Ward, H. W. C., Butt, W. R., Lynch, S. S., and Rudd, B. T. Recurrent breast cancer treated with the antioestrogen tamoxifen: correlation between hormonal changes and clinical course. Br. Med. J., 1: 425–429, 1977.
    • (1977) Br. Med. J. , vol.1 , pp. 425-429
    • Willis, K.J.1    London, D.R.2    Ward, H.W.C.3    Butt, W.R.4    Lynch, S.S.5    Rudd, B.T.6
  • 18
    • 0017796895 scopus 로고
    • Increases in steroid binding globulins induced by tamoxifen in patients with carcinoma of the breast
    • Sakai, F., Cheix, F., Clavel, M., et al. Increases in steroid binding globulins induced by tamoxifen in patients with carcinoma of the breast. J. Endocrinol., 76: 219–227, 1978.
    • (1978) J. Endocrinol. , vol.76 , pp. 219-227
    • Sakai, F.1    Cheix, F.2    Clavel, M.3
  • 20
    • 0023148339 scopus 로고
    • Use of the aromatase inhibitors 4-hydroxyandrostenedione in postmenopausal breast cancer: optimisation of therapeutic dose and route
    • Dowsett, M., Goss, P., Powles, T. J., Hutchinson, G., Brodie, A. M. H., Jeffcoate, S. L., and Coombes, R. C. Use of the aromatase inhibitors 4-hydroxyandrostenedione in postmenopausal breast cancer: optimisation of therapeutic dose and route. Cancer Res., 47: 1957–1961, 1987.
    • (1987) Cancer Res. , vol.47 , pp. 1957-1961
    • Dowsett, M.1    Goss, P.2    Powles, T.J.3    Hutchinson, G.4    Brodie, A.M.H.5    Jeffcoate, S.L.6    Coombes, R.C.7
  • 21
    • 0020374848 scopus 로고
    • Standardized multicentre procedure for plasma gonadotrophs radioimmunoassay
    • Ferguson, K., Hayes, M., and Jeffcoate, S. L. Standardized multicentre procedure for plasma gonadotrophs radioimmunoassay. Ann. Biochem., 19: 358–367, 1982.
    • (1982) Ann. Biochem. , vol.19 , pp. 358-367
    • Ferguson, K.1    Hayes, M.2    Jeffcoate, S.L.3
  • 22
    • 0022339556 scopus 로고
    • Oestrogen-related changes in sex hormone binding globulin levels during normal and gonadotrophin-stimulated menstrual cycles
    • Dowsett, M., Attree, S., Virdee, S., and Jeffcoate, S. L. Oestrogen-related changes in sex hormone binding globulin levels during normal and gonadotrophin-stimulated menstrual cycles. Clin. Endocrinol., 23: 303–312, 1985.
    • (1985) Clin. Endocrinol. , vol.23 , pp. 303-312
    • Dowsett, M.1    Attree, S.2    Virdee, S.3    Jeffcoate, S.L.4
  • 23
    • 0024584001 scopus 로고
    • Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment
    • Lien, E. A., Solheim, E., Lea, O. A., Lundgren, S., Kvinnsland, S., and Ueland, P. M. Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment. Cancer Res., 49: 2175–2183, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 2175-2183
    • Lien, E.A.1    Solheim, E.2    Lea, O.A.3    Lundgren, S.4    Kvinnsland, S.5    Ueland, P.M.6
  • 24
    • 0026488166 scopus 로고
    • Serum elimination half-life of tamoxifen and its metabolites, in patients with advanced breast cancer
    • De Vos, D., Slee, P. H. T. J., Stevenson, D., and Briggs, L. J. Serum elimination half-life of tamoxifen and its metabolites, in patients with advanced breast cancer. Cancer Chemother. Pharmacol., 31: 76–78, 1992.
    • (1992) Cancer Chemother. Pharmacol. , vol.31 , pp. 76-78
    • De Vos, D.1    Slee, P.H.T.J.2    Stevenson, D.3    Briggs, L.J.4
  • 25
    • 0019179910 scopus 로고
    • Clinical pharmacology of tamoxifen in patients with breast cancer: comparison of traditional and loading dose schedules
    • Fabian, C., Sternson, L., and Barnett, M. Clinical pharmacology of tamoxifen in patients with breast cancer: comparison of traditional and loading dose schedules. Cancer Treat Rep., 64: 765–773, 1980.
    • (1980) Cancer Treat Rep. , vol.64 , pp. 765-773
    • Fabian, C.1    Sternson, L.2    Barnett, M.3
  • 26
    • 0025133172 scopus 로고
    • Decreased serum concentrations of tamoxifen and its metabolites induced by aminoglutethimide
    • Lien, E. A., Anker, G., Lonning, P. E., Solheim, E., and Ueland, P. M. Decreased serum concentrations of tamoxifen and its metabolites induced by aminoglutethimide. Cancer Res., 50: 5851–5859, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 5851-5859
    • Lien, E.A.1    Anker, G.2    Lonning, P.E.3    Solheim, E.4    Ueland, P.M.5
  • 28
    • 0027716732 scopus 로고
    • Effect of oestrogen receptor status and time on th intra-tumoral accumulation of tamoxifen and N-desmethylta-moxifen following short-term therapy in human primary breast cancer
    • Johnston, S. R. D., Haynes, B. P., Sacks, N. P. M., MacKinna, J. A., Griggs, L. J., Jarman, M., Baum, M., Smith, I. E., and Dowsett, M. Effect of oestrogen receptor status and time on th intra-tumoral accumulation of tamoxifen and N-desmethylta-moxifen following short-term therapy in human primary breast cancer. Breast Cancer Res. Treat., 18: 241–250, 1993.
    • (1993) Breast Cancer Res. Treat. , vol.18 , pp. 241-250
    • Johnston, S.R.D.1    Haynes, B.P.2    Sacks, N.P.M.3    MacKinna, J.A.4    Griggs, L.J.5    Jarman, M.6    Baum, M.7    Smith, I.E.8    Dowsett, M.9
  • 29
    • 0020402019 scopus 로고
    • Metabolites of tamoxifen in animals and man: identification, pharmacology and significance
    • Jordan, V. C. Metabolites of tamoxifen in animals and man: identification, pharmacology and significance. Breast Cancer Res. Treat., 2: 123–138, 1982.
    • (1982) Breast Cancer Res. Treat. , vol.2 , pp. 123-138
    • Jordan, V.C.1
  • 30
    • 0022530741 scopus 로고
    • The steady-state pharmacokinetics of tamoxifen and its metabolites in breast cancer patients
    • Soininen, K., Kleimola, T., Elomaa, I., Salmo, M., and Rissanen, P. The steady-state pharmacokinetics of tamoxifen and its metabolites in breast cancer patients. J. Int. Med. Res., 14: 162–165, 1986.
    • (1986) J. Int. Med. Res. , vol.14 , pp. 162-165
    • Soininen, K.1    Kleimola, T.2    Elomaa, I.3    Salmo, M.4    Rissanen, P.5
  • 31
    • 0026648931 scopus 로고
    • Tamoxifen metabolism is altered by simultaneous administration of medroxyprogesterone acetate in breast cancer patients
    • Reid, A. D., Horobin, J. M., Newman, E. L., and Preece, P. E. Tamoxifen metabolism is altered by simultaneous administration of medroxyprogesterone acetate in breast cancer patients. Breast Cancer Res. Treat., 22: 153–156, 1992.
    • (1992) Breast Cancer Res. Treat. , vol.22 , pp. 153-156
    • Reid, A.D.1    Horobin, J.M.2    Newman, E.L.3    Preece, P.E.4
  • 32
    • 0025251643 scopus 로고
    • Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer
    • Langan-Fahey, S. M., Tormey, D. C., and Jordan, V. C. Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer. Eur. J. Cancer., 26: 883–888, 1990.
    • (1990) Eur. J. Cancer. , vol.26 , pp. 883-888
    • Langan-Fahey, S.M.1    Tormey, D.C.2    Jordan, V.C.3
  • 33
    • 0027426334 scopus 로고
    • Acquired tamoxifen resistance in human breast cancer and reduced intra-tumoural drug concentration
    • Johnston, S. R. D., Haynes, B. P., Smith, I. E., Jarman, M., Sacks, N. P. M., Ebbs, S. R., and Dowsett, M. Acquired tamoxifen resistance in human breast cancer and reduced intra-tumoural drug concentration. Lancet, 342: 1521–1522, 1993.
    • (1993) Lancet , vol.342 , pp. 1521-1522
    • Johnston, S.R.D.1    Haynes, B.P.2    Smith, I.E.3    Jarman, M.4    Sacks, N.P.M.5    Ebbs, S.R.6    Dowsett, M.7
  • 34
    • 0026064491 scopus 로고
    • Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient
    • Robinson, S. P., Langan-Fahey, S. M., Johnson, D. A., and Jordan, V. C., Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient. Drug Metab. Dispos., 19: 36–43, 1991.
    • (1991) Drug Metab. Dispos. , vol.19 , pp. 36-43
    • Robinson, S.P.1    Langan-Fahey, S.M.2    Johnson, D.A.3    Jordan, V.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.