Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance

Journal of Clinical Investigation

Volumn 95, Issue 5, 1995, Pages 2409-2415

  Hotamisligil, Gökhan S ^a   Arner, Peter ^b   Caro, José F ^c   Atkinson, Richard L ^d   Spiegelman, Bruce M ^e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

cytokines; fat; insulin action; non insulin dependent diabetes mellitus; weight loss

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; NORTHERN BLOTTING; OBESITY; PREMENOPAUSE; PRIORITY JOURNAL; WEIGHT REDUCTION;

EID: 0028931724     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117936     Document Type: Article

References (30)

1. Bennet, P. H. 1990. Epidemiology of diabetes mellitus. In Diabetes Mellitus. H. Rifkin, and J. D. Porte, editors. Eisevier Science Publishing Co., Inc., New York. 357-377.
2. Moller, D. E., and J. S. Flier. 1992. Insulin resistance: mechanisms, syndromes, and implications. N. Engl. J. Med. 325:938-948.
3. Olefsky, J. M., and J. M. Molina. 1990. Insulin resistance in man. In Diabetes Mellitus H. Rifkin and J. D. Porte, editors. Eisevier Science Publishing Co., Inc., New York. 121-153.
4. Himmsworth, H. P. 1939. The mechanisms of diabetes mellitus. IV. Human diabetes mellitus. Lancet. ii:171-176.
5. Old, L. J. 1985. Tumor necrosis factor (TNF). Science (Wash. DC). 230:630-633.
6. Pennica, D., G. E. Nedwin, J. S. Hayflick, P. H. Seeburg, R. Derynck, M. A. Palladino, W. J. Kohr, B. B. Aggarwal, and D. V. Goeddel. 1984. Human tumor necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature (Lond.). 312:724-727.
7. Beutler, B., and A. Cerami. 1989. The biology of cachectin/TNF-α primary mediator of the host response. Annu. Rev. Immunol. 7:625-655.
8. Grunfeld, C., and K. R. Feingold. 1991. The metabolic effects of tumor necrosis factor and other cytokines. Biotherapy. 3:143-158.
9. Hotamisligil, G. S., N. S. Shargill, and B. M. Spiegelman. 1993. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (Wash. DC). 259:87-91.
10. Hotamisligil, G. S., and B. M. Spiegelman. 1994. TNF-α: a key component of obesity-diabetes link. Diabetes. 43:1271-1278.
11. Hofmann, C., K. Lorenz, S. S. Braithwaite, B. J. Palazuk, G. S. Hotamisligil, and B. M. Spiegelman. 1994. Altered gene expression for tumor necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology. 134:264-270.
12. Folli, F., M. J. Saad, J. M. Backer, and C. R. Kahn. 1992. Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. J. Biol. Chem. 267:22171-22177.
13. Heydrick, S. J., D. Jullien, N. Gautier, J.-F. Tanti, S. Giorgetti, E. van Obberghen, and Y. Le Marchand-Brustel. 1993. Defect in skeletal muscle phosphatidylinositol-3′-kinase in obese insulin-resistant mice. J. Clin. Invest. 91:1358-1366.
14. Saad, M. J. A., E. Araki, M. Miralpeix, P. L. Rothenberg, M. F. White, and C. R. Kahn. 1992. Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J. Clin. Invest. 90:1839-1849.
15. Thies, R. S., J. M. Molina, T. P. Ciaraldi, G. R. Freidenberg, and J. M. Olefsky. 1990. Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects. Diabetes. 39:250-259.
16. Friedenberg, G. R., R. R. Henry, H. H. Klein, D. R. Reichart, and J. M. Olefsky. 1987. Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects. J. Clin. Invest. 79:240-250.
17. Feinstein, R., H. Kanety, M. Z. Papa, B. Lunenfeld, and A. Karasik. 1993. Tumor necrosis factor-α suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J. Biol. Chem. 268:26055-26058.
18. Hotamisligil, G. S., D. L. Murray, L. N. Choy, and B. M. Spiegelman. 1994. TNF-α inhibits signaling from insulin receptor. Proc. Natl. Acad. Sci. USA. 91:4854-4858.
19. Hotamisligil, G. S., A. Budavari, D. L. Murray, and B. M. Spiegelman. 1994. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes: central role of tumor necrosis factor-α. J. Clin. Invest. 94:1543-1549.
20. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294-5299.
21. Spiegelman, B. M., M. Frank, and H. Green. 1983. Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerolphosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J. Biol. Chem. 258:10083-10089.
22. Gray, P. W., B. B. Aggarwal, C. V. Benton, T. S. Bringman, W. J. Henzel, J. A. Jarret, D. W. Leung, B. Moffat, P. Ng, L. P. Svedersky, et al. 1984. Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumor necrosis activity. Nature (Lond.). 312:721-724.
23. Moses, A. C., and M. J. Abrahamson. 1993. Therapeutic approaches to insulin resistance. In Insulin Resistance. D. E. Moller, editor. John Wiley & Sons Ltd., Chicester, United Kingdom. 385-410.
24. Bjorntorp, P. 1992. Regional Obesity. In Obesity. P. Bjorntorp and B. D. Brodoff, editors. J. B. Lippincott. Philadelphia. 579-586.
25. Boeck, M. A., C. Chen, and S. Cunningham-Rundles. 1993. Altered immune function in a morbidly obese pediatric population. Ann. NY Acad. Sci. 699:252-256.
26. Prager, R., P. Wallace, and J. M. Olefsky. 1986. In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects. J. Clin. Invest. 78:472-481.
27. Norman, R. A., C. Bogardus, and E. Ravussin. 1994. Linkage of obesity with a DNA marker near the tumor necrosis factor-α locus. Int. J. Obes. 18(Suppl. 2):11.
28. Raptis, S., A. Mitrakou, D. Hadjidakis, E. Diamantopoulos, C. Anastasiou, A. Fountas, and R. Muller. 1987. 24-h blood glucose pattern in type I and type II diabetics after oral treatment with pentoxifylline as assessed by artificial endocrine pancreas. Acta Diabetol. Lat. 24:181-192.
29. Strieter, R. M., D. G. Remick, P. A. Ward, R. N. Spengler, J. P. Lynch III, J. Larrick, and S. L. Kunkel. 1988. Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem. Biophys. Res. Commun. 155:1230-1236.
30. Nolan, J. J., B. Ludvik, P. Beerdsen, M. Joyce, and J. M. Olefsky. 1994. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med. 331:1188-1193.