An E-box-mediated increase in cad transcription at the G1/S-phase boundary is suppressed by inhibitory c-Myc mutants

Molecular and Cellular Biology

Volumn 15, Issue 5, 1995, Pages 2527-2535

  Miltenberger, Rosalynn J ^a   Sukow, Kristine A ^a   Farnham, Peggy J ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE CARBAMOYLTRANSFERASE; BINDING PROTEIN; CARBAMOYL PHOSPHATE SYNTHASE;

ARTICLE; CELL GROWTH; DNA BINDING; DNA FLANKING REGION; ENZYME ACTIVITY; GENE MUTATION; GENE REPRESSION; GENE SEQUENCE; GENETIC CODE; GENETIC TRANSCRIPTION; NUCLEOTIDE SEQUENCE; ONCOGENE C MYC; PRIORITY JOURNAL;

CRICETINAE; MAMMALIA;

EID: 0028930840     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.15.5.2527     Document Type: Article

References (68)

1. Amati, B., S. Dalton, M. W. Brooks, T. D. Littlewood, G. I. Evan, and H. Land. 1992. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature (London) 359:423-426.
2. Ayer, D. E., and R. N. Eisenman. 1993. A switch from Myc:Max to Mad:Max hetercomplexes accompanies monocyte/macrophage differentiation. Genes Dev. 7:2110-2119.
3. Ayer, D. E., L. Kretzner, and R. N. Eisenman. 1993. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72:211-222.
4. Bandara, L. R., V. M. Buck, M. Zamanian, L. H. Johnston, and N. B. La Thangue. 1993. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F. EMBO J. 12:4317-4324.
5. Beckmann, H., L. Su, and T. Kadesch. 1990. TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer μE3 motif. Genes Dev. 4:167-179.
6. Bello-Fernandez, C., G. Packham, and J. L. Cleveland. 1993. The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc. Natl. Acad. Sci. USA 90:7804-7808.
7. 2 on specificity and comparison with binding of Myc family members. Nucleic Acids Res. 22:2801-2810.
8. Benvenisty, N., A. Leder, A. Kuo, and P. Leder. 1992. An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence. Genes Dev. 6:2513-2523.
9. Berberich, S., N. Hyde-DeRuyscher, P. Espenshade, and M. Cole. 1992. max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors. Oncogene 7:775-779.
10. Blackwood, E. M., and R. N. Eisenman. 1991. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251:1211-1217.
11. Blackwood, E. M., B. Lüscher, and R. N. Eisenman. 1992, Myc and Max associate in vivo. Genes Dev. 6:71-80.
12. Buermeyer, A. B., N. E. Thompson, L. A. Strasheim, R. R. Burgess, and P. J. Farnham. 1992. The HIP1 initiator element plays a role in determining the in vitro requirement of the dihydrofolate reductase gene promoter for the C-terminal domain of RNA polymerase II. Mol. Cell. Biol. 12:2250-2259.
13. Carr, C. S., and P. A. Sharp. 1990. A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol. Cell. Biol. 10:4384-4388.
14. Dang, CV., M. McGuire, M. Buckmire, and W. M. F. Lee. 1989. Involvement of the 'leucine zipper' region in the oligomerization and transforming activity of human c-myc protein. Nature (London) 337:664-666.
15. Dean, M., R. A. Levine, W. Ran, M. S. Kindy, G. E. Sonenshein, and J. Campisi. 1986. Regulation of c-myc transcription and mRNA abundance by serum growth factors and cell contact. J. Biol. Chem. 261:9161-9166.
16. Dignam, J. D., R. M. Lebovilz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
17. 1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. J. Biol. Chem. 269:1306-1313.
18. Eilers, M., S. Schirm, and J. M. Bishop. 1991. The MYC protein activates transcription of the ct-prothymosin gene. EMBO J. 10:133-141.
19. Eisenman, R. N., C. Y. Tachibana, H. D. Abrams, and S. R. Hann. 1985. v-myc and c-myc-encoded proteins are associated with the nuclear matrix. Mol. Cell. Biol. 5:114-126.
20. Evan, G. L, and T. D. Littlewood. 1993. The role of c-myc in cell growth. Curr. Opin. Genet. Dev. 3:44-49.
21. Evans, D. R. 1986. CAD, a chimeric protein that initiates de novo pyrimidine biosynthesis in higher eucaryotes, p. 283-331. In D. G. Hardie and J. R. Coggins (ed.), Multidomain proteins - structure and evolution. Elsevier Biomedical Press, Amsterdam.
22. Farnham, P. J., and R. Kollmar. 1990. Characterization of the 5′ end of the growth-regulated Syrian hamster CAD gene. Cell Growth Differ. 1:179-189.
23. Farnham, P. J., J. E. Slansky, and R. Kollmar. 1993. The role of E2F in the mammalian cell cycle. Biochim. Biophys. Acta 1155:125-131.
24. Gregor, P. D., M. Sawadogo, and R. G. Roeder. 1990. The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Dev. 4:1730-1740.
25. Halazonetis, T. D., and A. N. Kandil. 1991. Determination of the c-MYC DNA-binding site. Proc. Natl. Acad. Sci. USA 88:6162-6166.
26. 1. Nature (London) 328: 445-449.
27. Helin, K., C.-L. Wu, A. R. Fattaey, J. A. Lees, B. D. Dynlacht, C. Ngwu, and E. Harlow. 1993. Heterodimerization of the transcription factor E2F-1 and DPI leads to cooperative trans-activation. Genes Dev. 7:1850-1861.
28. Hsiao, K.-M., S. L. McMahon, and P. J. Farnham. 1994. Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev. 8:1526-1537.
29. Hu, Y., B. Lüscher, A. Admon, N. Mermod, and R. Tjian. 1990. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Genes Dev. 4:1741-1752.
30. Ivey-Hoyle, M., R. Conroy, H. E. Huber, P. J. Goodhart, A. Oliff, and D. C. Heimbrook. 1993. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol. Cell. Biol. 13:7802-7812.
31. Johnson, D. G., J. K. Schwarz, W. D. Cress, and J. R. Nevins. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature (London) 365:349-352.
32. Kato, G. J., J. Barrett, M. Villa-Garcia, and C. V. Dang. 1990. An aminoterminal domain of c-Myc required tor transformation activates transcription. Mol. Cell. Biol. 10:5914-5920.
33. Kelly, K., B. H. Cochran, C. D. Stiles, and P. Leder. 1983. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35:603-610.
34. Kollmar, R-, M. J. Lindstrom, and P. J. Farnham. 1992. Heat sensitivity and Sp1 activation of complex formation at the Syrian hamster carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/di-hydroorotase promoter in vitro. J. Biol. Chem. 267:385-391.
35. Kollmar, R., K. A. Sukow, S. K. Sponagle, and P. J. Farnham. 1994. Start site selection at the TATA-less carbamoyl-phosphate synthase (glutamine-hydrolyzing)/aspartate carbamoyltransferase/dihydroorotase promoter. J. Biol. Chem. 269:2252-2257.
36. Krek, W., D. M. Livingston, and S. Shirodkar. 1993. Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members. Science 262:1557-1560.
37. Kretzner, L., E. M. Blackwood, and R. N. Eisenman. 1992. Myc and Max proteins possess distinct transcriptional activities. Nature (London) 359:426-429.
38. Lam, E. W.-F., J. D. H. Morris, R. Davies, T. Crook, R. J. Watson, and K. H. Vousden. 1994. HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes. EMBO J. 13:871-878.
39. Lam, E. W.-F., and R. J. Watson. 1993. An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. EMBO J. 12:2705-2713.
40. Land, H., L. F. Parada, and R. A. Weinberg. 1983. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes, Nature (London) 304:596-602.
41. Letovsky, J., and W. S. Dynan. 1989. Measurement of the binding of transcription factor Sp1 to a single GC box recognition sequence. Nucleic Acids Res. 17:2639-2653.
42. Li, L., G. S. Naeve, and A. S. Lee. 1993. Temporal regulation of cyclin A-p107 and p33cdk2 complexes binding to a human thymidine kinase promoter element important for G1-S phase transcriptional regulation. Proc. Natl. Acad. Sci. USA 90:3554-3558.
43. Li, Y., J. E. Slansky, D. J. Myers, N. R. Drinkwater, W. G. Kaelin, and P. J. Farnham. 1994. Cloning, chromosomal location, and characterization of mouse E2F1. Mol. Cell. Biol. 14:1861-1869.
44. Lino, W. S. L., R. Heller, P. Green, and G. R. Stark. 1986. Regulation of carbamoyl phosphate synthetase-aspartate transcarbamoylase-dihydroorotase gene expression in growing and arrested cells. J. Biol. Chem. 261:15577-15581.
45. Lim, K., and C.-B. Chae. 1989. A simple assay for DNA transfection by incubation of the cells in culture dishes with substrates for beta-galactosidase. BioTechniques 7:576-579.
46. Lüscher, B., and R. N. Eisenman. 1990. New light on Myc and Myb. I. Myc. Genes Dev. 4:2025-2035.
47. Makino, R., K. Hayashi, and T. Sugimura. 1984. c-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment. Nature (London) 310:697-698.
48. Marcu, K. B., S. A. Bossone, and A. J. Patel. 1992. myc function and regulation. Annu. Rev. Biochem. 61:809-860.
49. Means, A. L., J. E. Slansky, S. L. McMahon, M. W. Knuth, and P. J. Farnham. 1992. The HIP1-binding site is required for growth regulation of the dihydrofolate reductase gene promoter. Mol. Cell. Biol. 12:1054-1063.
50. Miltenberger, R. J. Unpublished data.
51. Miltenberger, R. J., J. Cortner, and P. J. Farnham. 1993. An inhibitory Raf-1 mutant suppresses expression of a subset of v-raf-activated genes. J. Biol. Chem. 268:15674-15680.
52. Mudryj, M., S. W. Hiebert, and J. R. Nevins. 1990. A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 9:2179-2184.
53. Mukherjee, B., S. D. Morgenbesser, and R. A. DePinho. 1992. Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants. Genes Dev. 6:1480-1492.
54. Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
55. Pena, A., C. D. Reddy, S. Wu, N. J. Hickok, E. P. Reddy, G. Yumet, D. R. Soprano, and K. J. Soprano. 1993. Regulation of human ornithine decarboxylase expression by the c-Myc:c-Max protein complex. J. Biol. Chem. 268:27277-27285.
56. Prendergast, G. C., D. Lawe, and E. B. Ziff. 1991. Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and Ras cotransformation. Cell 65:395-407.
57. 1 progression in murine erythroleukemia cells. Mol. Cell. Biol. 8:3683-3695.
58. Rabbitts, P. H., J. V. Watson, A. Lamond, A. Forster, M. A. Stinson, G. Evan, W. Fischer, E. Atherton, R. Sheppard, and T. H. Rabbitts. 1985. Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle. EMBO J. 4:2009-2015.
59. Rao, G. N., and R. L. Church. 1988. Regulation of CAD gene expression in mouse fibroblasts during the transition from the resting to the growing state. Exp. Cell Res. 178:449-456.
60. Reisman, D., N. B. Elkind, B. Roy, J. Beamon, and V. Rotter. 1993. c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif. Cell Growth Differ. 4:57-65.
61. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
62. Singh, P., S. H. Wong, and W. Hong. 1994. Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J. 13:3329-3338.
63. Slansky, J. E., Y. Li, W. G. Kaelin, and P. J. Farnham. 1993. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol. Cell. Biol. 13:1610-1618. (Author's correction, 13:7201.)
64. Solomon, D. L. C., B. Amati, and H. Land. 1993. Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res. 21:5372-5376.
65. Thompson, C. B., P. B. Challoner, P. E. Neiman, and M. Groudine. 1985. Levels of c-myc oncogene mRNA are invariant throughout the cell cycle. Nature (London) 314:363-366,
66. Waters, C. M., T. D. Link-wood, D. C. Hancock, J. P. Moore, and G. I. Evan. 1991. c-myc protein expression in untransformed fibroblasts. Oncogene 6:797-805
67. Watt, R., L. W. Stanton, K. B. Marcu, R. C. Gallo, C. M. Croce, and G. Rovera. 1983. Nucleotide sequence of cloned cDNA of human c-myc oncogene. Nature (London) 303:725-728.
68. Zervos, A. S., J. Gyuris, and R. Brent. 1993. Mxil, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72:223-232.