Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation

Journal of Clinical Investigation

Volumn 95, Issue 4, 1995, Pages 1735-1740

  Coyle, Anthony J ^a,e   Ackerman, Steven J ^b   Burch, Ron ^c   Proud, David ^d   Irvin, Charles G ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c ASTRAZENECA   (United Kingdom)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e CIBA GEIGY LTD   (Switzerland)

Author keywords

airway hyperresponsiveness; bradykinin; cationic protein; eosinophil; major basic protein

Indexed keywords

BRADYKININ; BRADYKININ ANTAGONIST; BRADYKININ B2 RECEPTOR; KALLIKREIN; KININ; MAJOR BASIC PROTEIN; METHACHOLINE; NPC 17731; POLYCATION; POLYLYSINE; UNCLASSIFIED DRUG;

AIRWAY; ALLERGIC ASTHMA; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DOSE RESPONSE; EOSINOPHIL; FEMALE; INHALATIONAL DRUG ADMINISTRATION; KALLIKREIN KININ SYSTEM; LUNG FUNCTION; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0028930486     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117850     Document Type: Article

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