Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine

Journal of Experimental Medicine

Volumn 181, Issue 4, 1995, Pages 1519-1526

  Von Freeden Jeffry, Ursula ^a,b   Vieira, Paulo ^a   Lucian, Linda A ^a   McNeil, Tom ^a   Burdach, Stefan E G ^b   Murray, Richard ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 7;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; GENE DELETION; GENE TARGETING; LYMPHOCYTOPENIA; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN LYMPHOCYTE; T LYMPHOCYTE;

ANIMAL; BASE SEQUENCE; BONE MARROW; CONCANAVALIN A; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; INTERLEUKIN-2; INTERLEUKIN-7; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; LYMPHOID TISSUE; LYMPHOPENIA; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; SPLEEN; SUPPORT, NON-U.S. GOV'T; THYMUS GLAND;

EID: 0028929565     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.181.4.1519     Document Type: Article

References (28)

1. Schorle, H., T. Holtschke, T. Hunig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature (Lond.). 352: 621-624.
2. Kuhn, R., K. Rajewsky, and W. Muller. 1991. Generation and analysis of interleukin-4 deficient mice. Science (Wash. DC). 254: 707-710.
3. Kopf, M., H. Baumann, G. Freer, M. Freudenberg, M. Lamers, T. Kishimoto, R. Zinkernagel, H. Bluethmann, and G. Kohler. 1994. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature (Lond.). 368: 339-342.
4. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75: 263-274.
5. Huang, S., W. Hendriks, A. Althage, S. Hemmi, H. Bluethmann, R. Kamijo, J. Vilcek, R.M. Zinkernagel, and M. Aguet. 1993. Immune response in mice that lack the interferon-gamma receptor. Science (Wash. DC). 259: 1742-1745.
6. IL3 receptor-deficient mice are normal. Immunity. In press.
7. Namen, A.E., S. Lupton, K. Hjerrild, J. Wignall, D.Y. Mochizuki, A. Schmierer, B. Mosley, C.J. March, D. Urdal, S. Gillis, et al. 1988. Stimulation of B-cell. progenitors by cloned murine interleukin-7. Nature (Lond.). 333: 571-573.
8. Takeda, S., S. Gillis, and R. Palacios. 1989. In vitro effects of recombinant interleukin 7 on growth and differentiation of bone marrow pro-B- and pro-T-lymphocyte clones and fetal thymocyte clones. Proc. Natl. Acad. Sci. USA. 86: 1634-1638.
9. Suda, T., S. Okada, J. Suda, Y. Miura, M. Ito, T. Sudo, S. Hayashi, S. Nishikawa, and H. Nakauchi. 1989. A stimulatory effect of recombinant murine interleukin-7 (IL-7) on B-cell colony formation and an inhibitory effect of IL-1 alpha. Blood. 74: 1936-1941.
10. Lee, G., A.E. Namen, S. Gillis, L.R. Ellingsworth, and P.W. Kincade. 1989. Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming growth factor-beta. J. Immunol. 142: 3875-3883.
11. Murray, R., T. Suda, N. Wrighton, F. Lee, and A. Zlotnik. 1989. IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets. Int. Immunol. 1: 526-531.
12. Grabstein, K.H., T.J. Waldschmidt, F.D. Finkelman, B.W. Hess, A.R. Alpert, N.E. Boiani, A.E. Namen, and P.J. Morrissey. 1993. Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J. Exp Med. 178: 257-264.
13. Sudo, T., S. Nishikawa, N. Ohno, N. Akiyama, M. Tamakoshi, H. Yoshida, and S. Nishikawa. 1993. Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. USA. 90: 9125-9129.
14. Park, L.S., D.J. Friend, A.E. Schmierer, S.K. Dower, and A.E. Namen. 1990. Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7-dependent cell line. J. Exp. Med. 171: 1073-1089.
15. Noguchi, M., H. Yi, H.M. Rosenblatt, A.H. Filipovich, S. Adelstein, W.S. Modi, O.W. McBride, and W.J. Leonard. 1993. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell. 73: 147-157.
16. Noguchi, M., Y. Nakamura, S.M. Russell, S.F. Ziegler, M. Tsang, X. Cao, and W.J. Leonard. 1993. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (Wash. DC). 262: 1877-1880.
17. Kondo, M., T. Takeshita, M. Higuchi, M. Nakamura, T. Sudo, S. Nishikawa, and K. Sugamura. 1994. Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Science (Wish. DC). 263: 1453-1454.
18. Takeshita, T., H. Asao, K. Ohtani, N. Ishii, S. Kumaki, N. Tanaka, H. Munakata, M. Nakamura, and K. Sugamura. 1992. Cloning of the gamma chain of the human IL-2 receptor. Science (Wash. DC). 257: 379-382.
19. Kondo, M., T. Takeshita, N. Ishii, M. Nakamura, S. Watanabe, K. Arai, and K. Sugamura. 1993. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science (Wash. DC). 262: 1874-1877.
20. Russell, S.M., A.D. Keegan, N. Harada, Y. Nakamura, M. Noguchi, P. Leland, M.C. Friedmann, A. Miyajima, R.K. Puri, W.E. Paul, et al. 1993. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (Wash. DC). 262: 1880-1883.
21. Russell, S.M., J.A. Johnston, M. Noguchi, M. Kawamura, C.M. Bacon, M. Friedmann, M. Berg, D.W. Mcvicar, B.A. Witthuhn, O. Silvennoinen, et al. 1994. Interaction of il-2r-beta and gamma(c) chains with jakl and jak3: implications for xscid and xcid. Science (Wash. DC). 266: 1042-1045.
22. Giri, J.G., M. Ahdieh, J. Eisenman, K. Shanebeck, K. Grabstein, S. Kumaki, A. Namen, L.S. Park, D. Cosman, and D. Anderson. 1994. Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO (Eur. Mol. Biol. Organ.) J. 13: 2822-2830.
23. Peschon, J.J., P.J. Morrissey, K.H. Grabstein, F.J. Ramsdell, E. Maraskovsky, B.C. Gliniak, L.S. Park, S.F. Ziegler, D.E. Williams, C.B. Ware, et al. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp Med. 180: 1955-1960.
24. Hardy, R.R., C.E. Carmack, S.A. Shinton, J.D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp Med. 173: 1213-1225.
25. Henney, C.S. 1989. Interleukin 7: effects on early events in lymphopoiesis. Immunol. Today. 10: 170-173.
26. Watson, J.D., P.J. Morrissey, A.E. Namen, P.J. Conlon, and M.B. Widmer. 1989. Effect of IL-7 on the growth of fetal thymocytes in culture. J. Immunol. 143: 1215-1222.
27. DiSanto, J.P., W. Muller, D. Guy-Grand, A. Fischer, and K. Rajewsky. 1994. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc. Natl. Acad. Sci. USA. 92: 377-381.
28. Sadlack, B., R. Kuhn, H. Schorle, K. Rajewsky, W. Muller, and I. Horak. 1994. Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4. Eur. J. Immunol. 24: 281-284.