Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

Current Genetics

Volumn 27, Issue 4, 1995, Pages 320-329

  Prasad, Rajendra ^a   De Wergifosse, Philippe ^a   Goffeau, Andre ^a   Balzi, Elisabetta ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

ABC transporters; Candida albicans; Multidrug resistance; Saccharomyces cerevisiae

Indexed keywords

2,4 DINITROPHENOL; ANTIFUNGAL AGENT; CHLORAMPHENICOL; CYCLOHEXIMIDE; MEMBRANE PROTEIN; MICONAZOLE; NYSTATIN; OLIGOMYCIN;

AMINO ACID SEQUENCE; ARTICLE; CANDIDA ALBICANS; DRUG HYPERSENSITIVITY; GENE LIBRARY; GENE MAPPING; GENE SEQUENCE; ION TRANSPORT; MOLECULAR CLONING; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESTRICTION MAPPING;

AMINO ACID SEQUENCE; ANTIFUNGAL AGENTS; BASE SEQUENCE; CANDIDA ALBICANS; CLONING, MOLECULAR; DRUG RESISTANCE, MULTIPLE; FUNGAL PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; RESTRICTION MAPPING; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SUPPORT, NON-U.S. GOV'T; TRANSFORMATION, GENETIC;

CANDIDA ALBICANS; SACCHAROMYCES CEREVISIAE;

EID: 0028928549     PISSN: 01728083     EISSN: 14320983     Source Type: Journal    
DOI: 10.1007/BF00352101     Document Type: Article

References (34)

1. The multidrug-resistance gene PDR1 from Saccharomyces cerevisiae
2. Multiple or pleiotropic drug resistance in yeast
3. Genetics and biochemistry of yeast multidrug resistance
4. PDR5, a novel yeast multidrug-resistance-conferring transporter controlled by the transcription regulator PDR1
5. Saturation mutagenesis of a yeast his3 “TATA element”: genetic evidence for a specific TATA-binding protein
6. A sequence assembly and editing program for efficient management of large projects
7. The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes
8. Analysis of membrane and surface protein sequences with the hydrophobic moment plot
9. Recognition of protein-coding regions in DNA sequences
10. Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate
11. Biochemistry of multidrug resistance mediated by the multidrug transporter
12. Mammalian multidrug resistance gene: complete cDNA sequence indicates, strong homology to bacterial transport proteins
13. Fluconazole-resistant Candida in AIDS patients
14. Saccharomyces cerevisiae YDR1 which encodes a member of the ATP-binding cassett (ABC) superfamily is required for multidrug resistance
15. Resistance of Candida albicans to azole antifungal agents
16. Transformation of intact cells treated with alkali cations
17. The amiloride resistance gene, car 1 of Schizosaccharomyces pombe
18. Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells
19. Cloning by gene amplification of two loci conferring multidrug resistance in Saccharomyces
20. The yeast STE6 gene encodes a homologue of the mammalian multidrug-resistance P-glycoprotein
21. DNA sequence of the white lo us of Drosophila melanogaster
22. Improved tools for biological sequence comparison
23. Nutrient transport in Candida albicans, a pathogenic yeast
24. The product of the YCR105 gene located on the chromosome III from Saccharomyces cerevisiae presents homologies to ATP-dependent permeases
25. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
26. DNA sequencing with chain-terminating inhibitors
27. Cloning and sequence analysis of a Candida maltosa gene which confers resistance to cycloheximide
28. Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline N-oxide and other chemicals, encodes a 169-kDa protein homologous to ATP-dependent permeases
29. Naturally occurring poly (dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast
30. DNA sequence required for efficient transcription termination in yeast