Chemical mechanisms underlying the vasodilator and platelet anti-aggregating properties of S-nitroso-N-acetyl-dl-penicillamine and S-nitrosoglutathione

Bioorganic and Medicinal Chemistry

Volumn 3, Issue 1, 1995, Pages 1-9

  Askew, Stuart C ^a   Butler, Anthony R ^a   Flitney, Frederick W ^a   Kemp, Graham D ^a   Megson, Ian L ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ION; CYSTEINE; GAMMA GLUTAMYLTRANSFERASE; GLUTAMINE; METAL ION; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; S METHYLCYSTEINE; S NITROSOGLUTATHIONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY; ARTICLE; CONTROLLED STUDY; DRUG STABILITY; MUSCLE TONE; NONHUMAN; RAT; THROMBOCYTE AGGREGATION; VASODILATATION;

ANIMAL; CYSTEINE; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; IN VITRO; MOLECULAR STRUCTURE; NITROGEN OXIDES; NITROSO COMPOUNDS; PENICILLAMINE; PLATELET AGGREGATION INHIBITORS; RATS; RATS, WISTAR; S-NITROSO-N-ACETYLPENICILLAMINE; S-NITROSOGLUTATHIONE; SUPPORT, NON-U.S. GOV'T; VASODILATOR AGENTS;

EID: 0028928312     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(94)00139-T     Document Type: Article

References (25)

1. An unusually stable thionitrite from N-acetyl-D,L-penicillamine; X-ray crystal and molecular structure of 2-(acetylamino)-2-carboxy-1,1-dimethylethyl thionitrite
2. Metal ion catalysis in nitrosothiol (RSNO) decomposition
3. Reactions of nitric oxide with methemoglobin
4. Electron paramagnetic resonance study of nitrosylmyoglobin