Failure of B Cells of Chronic Lymphocytic Leukemia in Presenting Soluble and Alloantigens

Clinical Immunology and Immunopathology

Volumn 75, Issue 1, 1995, Pages 26-32

  Dazzi, F ^a   D'Andrea E ^a   Biasi, G ^a   De Silvestro, G ^b   Gaidano, G ^c   Schena, M ^c   Tison, T ^a   Vianello, F ^a   Girolami, A ^a   Caligaris Cappio, F ^c  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; INTERLEUKIN 4; RECOMBINANT INTERLEUKIN 2; TETANUS TOXOID;

ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MIXED LYMPHOCYTE REACTION; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTIGEN PRESENTATION; B-LYMPHOCYTES; CELLS, CULTURED; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DR ANTIGENS; HUMAN; INTERLEUKIN-1; INTERLEUKIN-4; ISOANTIGENS; LEUKEMIA, B-CELL, CHRONIC; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; SOLUBILITY; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TETANUS TOXOID; TIME FACTORS;

EID: 0028927836     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1995.1048     Document Type: Article

References (32)

1. Pierce, S. K., Morris, J. F., Grusby, M. J., Kaumaya, P., Van Buskirk, A., Srinivasa, M., Crump, B., and Smolenski, L. A., Antigen-presenting function of B lymphocytes. Immunol. Rev. 106, 149-169, 1988.
2. Lanzavecchia, A., Antigen specific interaction between T and B cells. Nature 314, 537-539, 1985.
3. Krieger, J. I., Chesnut, R. W., and Grey, H. M., Capacity of B cells to function as stimulators of a primary mixed leukocyte reaction. J. Immunol. 137, 3117-3121, 1986.
4. Issekutz, T., Chu, E., and Geha, R. S., Antigen presentation by human B cells: T cells proliferation induced by Epstein-Barr virus T lymphoblastoid cells. J. Immunol. 129, 1446-1450, 1982.
5. Minami, M., Ebner, S. A., Stadecker, M. J., and Dorf, M. E., The effects of phorbol ester on alloantigen presentation. J. Immunol. 138, 393-396, 1986.
6. Casten, L. A., Lakey, E. K., Jelachich, M. L., Margoliash, E., and Pierce, S. K., Anti-immunoglobulin augments the B cell antigen presentation function independently of internalization of receptor-antigen complex. Proc. Natl. Acad. Sci. USA 82, 5890-5896, 1985.
7. Kakiuchi, T., Chesnut, R. W., and Grey, H. M., B cells as antigen-presenting cells: The requirement for B cell activation. J. Immunol. 131, 109-113, 1983.
8. Kurt-Jones, E. A., Liano, D., Hay Glass, K. A., Benacerraf, B., Sy, M., and Abbas., A., The role of antigen-presenting B cells in T cell priming in vivo. J. Immunol. 140, 3773-3778, 1988.
9. Cerny, A., Hugin, A. W., Sutter, S., Bazin, H., Hengartner, H. H., and Zinkernagel, R. M., Immunity to lymphocytic choriomeningitis virus in B cell-depleted mice: Evidence for B cell and antibody independent protection by memory T cells. Eur. J. Immunol. 16, 913-919, 1986.
10. Yasukawa, M., Shiroguchi, T., Inatsuki, A., and Kobayashi, Y., Antigen presentation in an HLA-DR-restricted fashion by B-cell chronic lymphocytic leukemia cells. Blood 72, 102-108, 1988.
11. Chesnut, R. W., Colon, S. M., and Grey, H. M., Antigen presentation by normal B cells, B cell tumors and macrophages: Functional and biochemical comparison. J. Immunol. 128, 1764-1768, 1982.
12. Cohen, H. I., Human lymphocyte surface immunoglobulin capping. Normal characteristics and anomalous behavior of chronic lymphocytic leukemia. J. Clin. Invest. 5, 84-87, 1975.
13. Caligaris-Cappio, F., Bergui, L., Tesio, L., Corbascio, G., Tuosco, F., and Marchisio, P. C., Cytoskeleton organization is aberrantly rearranged in the cells of B chronic lymphocytic leukemia and hairy cell leukemia. Blood 67, 233-239, 1986.
14. Karray, S., Merle-Beral, H., Vasquez, A., Gerard, J. P., Debre, P., and Galanaud, P., Functional heterogeneity of B-CLL lymphocytes: Dissociated responsiveness to growth factors and distinct requirements for a first activation signal. Blood 70, 1105-1110, 1987.
15. Ayanlar Batuman, O., Ebert, E., and Hauptman, S. P., Defective interleukin-2 production and responsiveness by T cells in patients with chronic lymphocytic leukemia of B cell variety. Blood 67, 279-284, 1986.
16. Kay, N. E., and Kaplan, M. E., Defective T cell responsiveness in chronic lymphocytic leukemia: Analysis of activation events. Blood 67, 578-581, 1986.
17. Kucinka, J., and Platsoucas, C D., Defective helper function of purified T4 cells and excessive suppressor activity of purified T8 cells in patients with B-cell chronic lymphocytic leukemia. T4 suppressor effector cells are present in certain patients. Blood 71, 1551-1560, 1988.
18. Wolos, J. A., and Davey, F. R., B lymphocyte function in B cell chronic lymphocytic leukaemia. Br. J. Haematol. 49, 395-403, 1981.
19. Burton, J. D., Weitz, C. H., and Kay, N. E., Malignant chronic lymphocytic leukemia B cells elaborate soluble factors that down-regulate T cell and NK function. Am. J. Hematol. 30, 61-63, 1989.
20. Cowing, C., and Chapdelaine, J. M., T cells discriminate between la antigens expressed on allogeneic accessory cells and B cells: A potential function for carbohydrate side chains on la molecules. Proc. Natl. Acad. Sci. USA 80, 6000-6004, 1983.
21. Sanders, V. M., Fernandez-Botran, R., Uhr, J. W., and Vitetta, E. S., Interleukin 4 enhances the ability of antigen-specific B cells to form conjugates with T cells. J. Immunol. 139, 2349-2353, 1987.
22. Weiss, L., Haeffber-Cavaillon, N., Laude, M., Cavaillon, J. M., and Kazatchkine, M. D., Human T cells and interleukin-4 inhibit the release of interleukin-1 induced by lipopolysaccharide in serum-free cultures of autologous monocytes. Eur. J. Immunol. 19, 1347-1350, 1989.
23. Han, T., and Dadey, B., In vitro functional studies of mononuclear cells in patients with CLL. Evidences for functionally normal T lymphocytes and monocytes and abnormal B lymphocytes. Cancer 43, 109-117, 1979.
24. Foà, R., Giovarelli, M., Jemma, C., Fierro, M. T., Lusso, P., Ferrando, M. L., Lauria, F., and Fomi, G., Interleukin-2 and interferon-gamma production by T lymphocytes from patients with B-chronic lymphocytic leukemia: Evidence that normally released IL-2 is absorbed by the neoplastic B cell population. Blood 66, 614-619, 1985.
25. Liu, Y., and Mullbacher, A., Activated B cells can deliver help for the in vitro generation of antiviral cytotoxic T cells. Proc. Natl. Acad. Sci. USA 86, 4629-4633, 1989.
26. Mizuochi, T., Mizuguchi, J., Uchida, T., Ohnishi, K., Nakanishi, M., Asano, Y., Kakiuchi, T., Fukushima, Y., Okuyama, K., Morse, H. C., and Komuro, K., A selective signaling defect in helper T cells induced by antigen-presenting cells from mice with murine acquired immunodeficiency syndrome. J. Immunol. 144, 313-316, 1990.
27. Lassila, O., Vainio, A., and Matzinger, P., Can B cells turn on virgin T cells? Nature 334, 253-256, 1988.
28. Jenkins, M. K., and Johnson, J. G., Molecules involved in T-cell co-stimulation. Curr. Opin. Immunol. 5, 361-367, 1993.
29. Ronchese, F. R., Brown, M. A., and Germain, R. N., Structure-function analsis of the Abbm12 mutation using site-directed mutagenesis and DNA-mediated gene transfer. J. Immunol. 139, 629-631, 1987.
30. Angelini, G., Fossati, G., Radice, P., Longo, A., Piccioli, P., Pierotti, M. A., Ferrara, G. B., and Parmiani, G., Loss of polymorphic restriction fragments of class I and class II MHC genes in a malignant melanoma. J. Immunogenetic. 13, 241-246, 1986.
31. Alexander, M., Bennicelli, J., and Guerry, D., Defective antigen presentation by human melanoma cell lines cultured from advanced, but not biologically early, disease. J. Immunol. 142, 4070-4078, 1989.
32. Pistoia, V., Cozzolino, F., Rubartelli, A., Torcia, M., Roncella, S., and Ferrarini, M., In vitro production of interleukin-1 by normal and malignant human B lymphocytes. J. Immunol. 136, 1688-1692, 1986.