The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery

European Journal of Pharmacology

Volumn 273, Issue 1-2, 1995, Pages 153-159

  Zhou, Qin ^a   Satake, Nobuhiro ^a   Shibata, Shoji ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

cGMP; Cromakalim; Detrusor muscle, rat; Femoral artery, rat; K+ channel; Nicorandil

Indexed keywords

ACETYLCHOLINE; APAMIN; CROMAKALIM; CYCLIC GMP; GLIBENCLAMIDE; GLYCERYL TRINITRATE; GUANYLATE CYCLASE; METHYLENE BLUE; N(G) METHYLARGININE; NICORANDIL; PHENYLEPHRINE; POTASSIUM CHANNEL; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; BLADDER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; ELECTROSTIMULATION; FEMORAL ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION;

ACETYLCHOLINE; ANIMAL; BENZOPYRANS; BLADDER; CROMAKALIM; CYCLIC GMP; ELECTRIC STIMULATION; FEMORAL ARTERY; GUANYLATE CYCLASE; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; NIACINAMIDE; NICORANDIL; NITROGLYCERIN; POTASSIUM CHANNELS; POTASSIUM CHLORIDE; PYRROLES; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 0028926438     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(94)00685-Z     Document Type: Article

References (37)

1. Clinical pharmacology of potassium channel openers
2. Effects of pinacidil on bladder muscle
3. Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein
4. ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder
5. +-channel opening and guanylate cyclase stimulation to its vasorelaxant effects on various endothelin-1-contracted arterial preparations, comparison to aprokalim (RP 52891) and nitroglycerin
6. Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels
7. Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro
8. Relationship between relaxation and cyclic GMP formation caused by nicorandil in canine mesenteric arteries
9. The effects of cromakalim on the detrusor muscle of human and pig urinary bladder
10. Potassium channel blockers and the effect of cromakalim on the smooth muscle of the guinea-pig bladder
11. + channel from rabbit aorta: modulation by cromakalim
12. Relationship between cyclic guanosine 3′:5′-monophosphate formation and relaxation of coronary arterial smooth muscle by glycerol trinitrate, nitroprusside, nitrite and nitric oxide: effect of methylene blue and methemoglobin
13. Macrophage cytotoxicity: role for l-arginine deiminase and imino nitrogen oxidation to nitrite
14. +-channels and cyclic GMP as components of vasodilation by nicorandil
15. Effects of 2-nicotinamidoethyl nitrate (nicorandil: SG-75) and its derivatives on smooth muscle cells of the canine mesenteric artery
16. Effect of 2-nicotinamidoethyl nitrate on smooth muscle cells of guinea-pig mesenteric and portal vein
17. Effect of nicorandil on exercise performance in patient with effort angina, a multicenter trial using a treadmill exercise test
18. Effect of a new coronary vasodilator, nicorandil, on variant angina
19. Dual mechanism of the relaxing effect of nicorandil by stimulation of cyclic GMP formation and by hyperpolarization
20. + channel opening to nicorandil-induced vasorelaxation depends on the conduit vessel and on the nature of the spasmogen
21. Effects of cromakalim (BRL 3915) and pinacidil on normal and hypertrophied rat detrusor in vitro
22. + channel-dependent and cyclic GMP-dependent components in a single vascular preparation
23. Regional difference in functional roles of cAMP and cGMP in lower urinary tract smooth muscle contractility
24. Comparison of the inhibitory effects of nicorandil, nitroglycerin and isosorbide dinitrate on vascular smooth muscle of rabbit aorta
25. Characteristics of cromakalim-induced relaxations in the smooth muscle cells of guinea-pig mesenteric artery and vein
26. Calcium channels potassium channels and voltage dependence of arterial smooth muscle tone
27. l-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation
28. Effects of inhibition of the l-arginine/nitric oxide pathway in the rat lower urinary tract in vivo and in vitro
29. Potassium channel openers: pharmacological and clinic aspects
30. + channels
31. On the pharmacological and physiological role of glibenclamide-sensitive potassium channels in colonic smooth muscle
32. + channels in cerebral artery smooth muscle cells
33. Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries
34. Stimulation of coronary guanylate cyclase by nicorandil (SG-75) as a mechanism of its vasodilating action
35. + channels in arterial smooth muscle
36. ATP-induced hyperpolarization of smooth muscle cells of the guinea-pig coronary artery
37. Nicorandil in the treatment of angina pectoris