메뉴 건너뛰기




Volumn 55, Issue 8, 1995, Pages 1780-1786

Effects of Tamoxifen Administration on the Expression of Xenobiotic Metabolizing Enzymes in Rat Liver

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; PHENOBARBITAL; TAMOXIFEN;

EID: 0028925204     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (42)

References (60)
  • 2
    • 0015915672 scopus 로고
    • Anti-oestrogen therapy for breast cancer: a trial of tamoxifen at two dose levels
    • Ward, H. W. C. Anti-oestrogen therapy for breast cancer: a trial of tamoxifen at two dose levels. Br. Med. J., 1: 13–14, 1973.
    • (1973) Br. Med. J. , vol.1 , pp. 13-14
    • Ward, H.W.C.1
  • 3
    • 0023199112 scopus 로고
    • Prolonging tamoxifen therapy for primary breast cancer
    • Fisher, B., Brown, A., Wolmark, N., et al Prolonging tamoxifen therapy for primary breast cancer. Ann. Intern. Med., 106: 649–654, 1987.
    • (1987) Ann. Intern. Med. , vol.106 , pp. 649-654
    • Fisher, B.1    Brown, A.2    Wolmark, N.3
  • 4
    • 0023674902 scopus 로고
    • Long-term tamoxifen therapy to control or to prevent breast cancer: laboratory concept to clinical trial
    • W. D. Hankins (ed.) New York: Alan R. Liss, Inc.
    • Jordan, V. C. Long-term tamoxifen therapy to control or to prevent breast cancer: laboratory concept to clinical trial, In: W. D. Hankins (ed.), Hormones, Cell Biology, and Cancer: Perspectives and Potentials, pp. 105–123. New York: Alan R. Liss, Inc., 1988.
    • (1988) Hormones, Cell Biology, and Cancer: Perspectives and Potentials , pp. 105-123
    • Jordan, V.C.1
  • 6
    • 0026425653 scopus 로고
    • Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment
    • lien, E. A., Solheim, E., and Ueland, P. M. Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment. Cancer Res., 51: 4837–4844, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 4837-4844
    • lien, E.A.1    Solheim, E.2    Ueland, P.M.3
  • 7
    • 0028177045 scopus 로고
    • A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes
    • Lim, C. K., Yuan, Z., Lamb, J. H., White, I. N. H., De Matteis, F., and Smith, L. L. A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes. Carcinogenesis (Lond.), 75: 589–593, 1994.
    • (1994) Carcinogenesis (Lond.) , vol.75 , pp. 589-593
    • Lim, C.K.1    Yuan, Z.2    Lamb, J.H.3    White, I.N.H.4    Matteis, F.5    Smith, L.L.6
  • 8
    • 0026064491 scopus 로고
    • Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient
    • Robinson, S. P., Langan-Fahey, S. M., Johnson, D. A., and Jordan, V. C. Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient. Drug Metab. Dispos., 19: 36–43, 1991.
    • (1991) Drug Metab. Dispos. , vol.19 , pp. 36-43
    • Robinson, S.P.1    Langan-Fahey, S.M.2    Johnson, D.A.3    Jordan, V.C.4
  • 9
    • 0025872863 scopus 로고
    • Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes
    • Jacolot, F., Simon, I., Dreano, Y., Beaune, P., Riche, C., and Berthou, F. Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes. Biochem. Pharmacol., 41: 1911–1919, 1991.
    • (1991) Biochem. Pharmacol. , vol.41 , pp. 1911-1919
    • Jacolot, F.1    Simon, I.2    Dreano, Y.3    Beaune, P.4    Riche, C.5    Berthou, F.6
  • 10
    • 0027221052 scopus 로고
    • Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. 1. Cytochrome P450-catalyzed iV-Demethylation and 4-hydroxylation
    • Mani, C., Gelboin, H. V., Park, S. S., Pearce, R., Parkinson, A., and Kupfer, D. Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. 1. Cytochrome P450-catalyzed iV-Demethylation and 4-hydroxylation. Drug Metab. Dispos., 21: 645–656, 1993.
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 645-656
    • Mani, C.1    Gelboin, H.V.2    Park, S.S.3    Pearce, R.4    Parkinson, A.5    Kupfer, D.6
  • 11
    • 0027198580 scopus 로고
    • Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-oxidation
    • Mani, C., Hodgson, E., and Kupfer, D. Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-oxidation. Drug Metab. Dispos., 21: 657–661, 1993.
    • (1993) Drug Metab. Dispos. , vol.21 , pp. 657-661
    • Mani, C.1    Hodgson, E.2    Kupfer, D.3
  • 12
    • 0027201501 scopus 로고
    • Two-year carcinogenicity study in Alderley Park Wistar-derived rats
    • Greaves, P., Goonetillek, R., Nunn, G., Topham, J., and Orton, T. Two-year carcinogenicity study in Alderley Park Wistar-derived rats. Cancer Res., 53: 3919–3924, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 3919-3924
    • Greaves, P.1    Goonetillek, R.2    Nunn, G.3    Topham, J.4    Orton, T.5
  • 13
    • 0027428568 scopus 로고
    • Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats
    • Hard, G. C., Iatropoulos, M. J., Jordan, K., Radi, L., Kaltenberg, O. P., Imondi, A. R., and Williams, G. M. Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats. Cancer Res., 53: 4534–4541, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 4534-4541
    • Hard, G.C.1    Iatropoulos, M.J.2    Jordan, K.3    Radi, L.4    Kaltenberg, O.P.5    Imondi, A.R.6    Williams, G.M.7
  • 14
    • 0027397629 scopus 로고
    • Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens
    • Hirsimaki, P., Hirsimaki, Y., Nieminen, L., and Payne, B. J. Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens. Arch. Toxicol., 67: 49–54, 1993.
    • (1993) Arch. Toxicol. , vol.67 , pp. 49-54
    • Hirsimaki, P.1    Hirsimaki, Y.2    Nieminen, L.3    Payne, B.J.4
  • 16
    • 0026319776 scopus 로고
    • Cytochrome P450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation
    • Mani, C., and Kupfer, D. Cytochrome P450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation. Cancer Res., 57: 6052–6058, 1991.
    • (1991) Cancer Res. , vol.57 , pp. 6052-6058
    • Mani, C.1    Kupfer, D.2
  • 17
    • 0026606580 scopus 로고
    • Induction of covalent DNA adducts in rodents by tamoxifen
    • Han, X., and Liehr, J. G. Induction of covalent DNA adducts in rodents by tamoxifen. Cancer Res., 52: 1360–1363, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 1360-1363
    • Han, X.1    Liehr, J.G.2
  • 18
    • 0028035492 scopus 로고
    • Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s
    • Styles, J. A., Davies, A., Lim, C. K., De Matteis, F., Stanley, L. A., White, I. N. H., Yuan, Z-X., and Smith, L. L. Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s. Carcinogenesis (Lond.), 75: 5–9, 1994.
    • (1994) Carcinogenesis (Lond.) , vol.75 , pp. 5-9
    • Styles, J.A.1    Davies, A.2    Lim, C.K.3    Matteis, F.4    Stanley, L.A.5    White, I.N.H.6    Yuan, Z-X.7    Smith, L.L.8
  • 19
    • 0027054733 scopus 로고
    • Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells
    • White, I. N. H., de Matteis, F., Davies, A., Smith, L. L., Crofton-Sleigh, C., Venitt, S., Hewer, A., and Phillips, D. H. Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells. Carcinogenesis (Lond.), 13: 2197–2203, 1992.
    • (1992) Carcinogenesis (Lond.) , vol.13 , pp. 2197-2203
    • White, I.N.H.1    Matteis, F.2    Davies, A.3    Smith, L.L.4    Crofton-Sleigh, C.5    Venitt, S.6    Hewer, A.7    Phillips, D.H.8
  • 20
    • 0028233205 scopus 로고
    • Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats
    • Sargent, L. M., Dragan, Y. P., Bahnub, N., Wiley, J. E., Sattler, C. A., Schroeder, P., Sattler, G. L., Jordan, V. C., and Pitot, H. C. Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats. Cancer Res., 54: 3357–3360, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 3357-3360
    • Sargent, L.M.1    Dragan, Y.P.2    Bahnub, N.3    Wiley, J.E.4    Sattler, C.A.5    Schroeder, P.6    Sattler, G.L.7    Jordan, V.C.8    Pitot, H.C.9
  • 21
    • 0028210878 scopus 로고
    • DNA adduct formation by tamoxifen with rat and human liver microsomal activation systems
    • Pathak, D. P., and Bodell, W. J. DNA adduct formation by tamoxifen with rat and human liver microsomal activation systems. Carcinogenesis (Lond.), 75: 529–532, 1994.
    • (1994) Carcinogenesis (Lond.) , vol.75 , pp. 529-532
    • Pathak, D.P.1    Bodell, W.J.2
  • 22
    • 0028326053 scopus 로고
    • A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism
    • Potter, G. A., McCague, R., and Jarman, M. A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism. Carcinogenesis (Lond.), 75: 439–442, 1994.
    • (1994) Carcinogenesis (Lond.) , vol.75 , pp. 439-442
    • Potter, G.A.1    McCague, R.2    Jarman, M.3
  • 23
    • 0028172242 scopus 로고
    • α-Hy-droxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes
    • Phillips, D. H., Carmichael, P. L., Hewer, A., Cole, K. J., and Poon, G. K. α-Hy-droxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. Cancer Res., 54: 5518–5522, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 5518-5522
    • Phillips, D.H.1    Carmichael, P.L.2    Hewer, A.3    Cole, K.J.4    Poon, G.K.5
  • 24
    • 0028168009 scopus 로고
    • Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates α-hy-droxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen
    • Phillips, D. H., Potter, G. A., Horton, M. N., Hewer, A., Crofton-Sleigh, C., Jarman, M., and Venitt, S. Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates α-hy-droxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen. Carcinogenesis (Lond.), 75: 1487–1492, 1994.
    • (1994) Carcinogenesis (Lond.) , vol.75 , pp. 1487-1492
    • Phillips, D.H.1    Potter, G.A.2    Horton, M.N.3    Hewer, A.4    Crofton-Sleigh, C.5    Jarman, M.6    Venitt, S.7
  • 25
    • 0028670421 scopus 로고
    • Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes
    • Mani, C., Pearce, R., Parkinson, A., and Kupfer, D. Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes. Carcinogenesis (Lond.), 75: 2715–2720, 1994.
    • (1994) Carcinogenesis (Lond.) , vol.75 , pp. 2715-2720
    • Mani, C.1    Pearce, R.2    Parkinson, A.3    Kupfer, D.4
  • 26
    • 0020956335 scopus 로고
    • Effects of phenobarbital, trans-stilbene oxide, and 3-methylcholanthrene on epoxide hydrolase within centrilobular, midzonal, and periportal regions of rat liver
    • Kawabata, T. T., Geungerich, F. P., and Baron, J. Effects of phenobarbital, trans-stilbene oxide, and 3-methylcholanthrene on epoxide hydrolase within centrilobular, midzonal, and periportal regions of rat liver. J. Biol. Chem., 256: 7767–7773 1983.
    • (1983) J. Biol. Chem. , vol.256 , pp. 7767-7773
    • Kawabata, T.T.1    Geungerich, F.P.2    Baron, J.3
  • 27
    • 0020641086 scopus 로고
    • Variations in induction of drug-metabolizing enzymes by trans-stilbene oxide in rodent species
    • Thabrew, M. I., and Emerole, G. O. Variations in induction of drug-metabolizing enzymes by trans-stilbene oxide in rodent species. Biochim. Biophys. Acta, 756: 242–246, 1983.
    • (1983) Biochim. Biophys. Acta , vol.756 , pp. 242-246
    • Thabrew, M.I.1    Emerole, G.O.2
  • 28
    • 0019481015 scopus 로고
    • Effect of tamoxifen treatment on liver, lung and intestinal mixed-function oxidases in male and female rats
    • Al-Turk, W. A., Stohs, S. J., and Roche, E. B. Effect of tamoxifen treatment on liver, lung and intestinal mixed-function oxidases in male and female rats. Drug Metab. Dispos., 9: 327–330, 1981.
    • (1981) Drug Metab. Dispos. , vol.9 , pp. 327-330
    • Al-Turk, W.A.1    Stohs, S.J.2    Roche, E.B.3
  • 29
    • 0017714627 scopus 로고
    • Inhibition of the l-(o-chlorophenyl)-l-(p-chlorophe-nyl)-2,2,2-trichloroethane (o, p'DDT)- and estradiol-mediated induction of rat uterine ornithine decarboxylase by prior treatment with o, p'DDT, estradiol, and tamoxifen
    • Bulger, W. H., and Kupfer, D. Inhibition of the l-(o-chlorophenyl)-l-(p-chlorophe-nyl)-2,2,2-trichloroethane (o, p'DDT)- and estradiol-mediated induction of rat uterine ornithine decarboxylase by prior treatment with o, p'DDT, estradiol, and tamoxifen. Arch. Biochem. Biophys., 182: 138–146, 1977.
    • (1977) Arch. Biochem. Biophys. , vol.182 , pp. 138-146
    • Bulger, W.H.1    Kupfer, D.2
  • 30
    • 84914648189 scopus 로고
    • Tamoxifen induces hepatic cytochrome P450 IIB1 and IIB2 in F344 rats
    • Nuwaysir, E. F., Dragan, Y. P., and Pitot, H. C. Tamoxifen induces hepatic cytochrome P450 IIB1 and IIB2 in F344 rats. The Toxicologist, 72: 917, 1992.
    • (1992) The Toxicologist , vol.72 , pp. 917
    • Nuwaysir, E.F.1    Dragan, Y.P.2    Pitot, H.C.3
  • 31
    • 0027389764 scopus 로고
    • Induction of CYP2B1 and 3A1, and associated monooxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice
    • White, I. N. H., Davies, A., Smith, L. L., Dawson, S., and de Matteis, F. Induction of CYP2B1 and 3A1, and associated monooxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice. Biochem. Pharmacol., 45: 21–30, 1993.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 21-30
    • White, I.N.H.1    Davies, A.2    Smith, L.L.3    Dawson, S.4    Matteis, F.5
  • 32
    • 0028263871 scopus 로고
    • Alterations of drug metabolizing and antioxidant enzyme activities during tamoxifen-induced hepatocar-cinogenesis in the rat
    • Ahotupa, M., Hirsimaki, P., Parssinen, R., and Mantyla, E. Alterations of drug metabolizing and antioxidant enzyme activities during tamoxifen-induced hepatocar-cinogenesis in the rat. Carcinogenesis (Lond.), 75: 863–868, 1994.
    • (1994) Carcinogenesis (Lond.) , vol.75 , pp. 863-868
    • Ahotupa, M.1    Hirsimaki, P.2    Parssinen, R.3    Mantyla, E.4
  • 33
    • 0016174577 scopus 로고
    • Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phos-phate-cytochrome P-450 reductase from rabbit liver microsomes
    • Van Der Hoeven, T. A., and Coon, M. J. Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phos-phate-cytochrome P-450 reductase from rabbit liver microsomes. J. Biol. Chem., 249: 6302–6310, 1974.
    • (1974) J. Biol. Chem. , vol.249 , pp. 6302-6310
    • Van Der Hoeven, T.A.1    Coon, M.J.2
  • 34
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248–254, 1976.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 35
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156–158, 1987.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-158
    • Chomczynski, P.1    Sacchi, N.2
  • 36
    • 0020601879 scopus 로고
    • Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species
    • Kumar, A., Raphael, C., and Adesnik, M. Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species. J. Biol. Chem., 258: 11280–11284, 1983.
    • (1983) J. Biol. Chem. , vol.258 , pp. 11280-11284
    • Kumar, A.1    Raphael, C.2    Adesnik, M.3
  • 37
    • 0021217332 scopus 로고
    • Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholan-threne-inducible cytochrome P1450 and P3–450
    • Gonzalez, F. J., Mackenzie, P. I., Kimura, S., and Nebert, D. W. Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholan-threne-inducible cytochrome P1450 and P3–450. Gene (Amst.), 29: 281–292, 1984.
    • (1984) Gene (Amst.) , vol.29 , pp. 281-292
    • Gonzalez, F.J.1    Mackenzie, P.I.2    Kimura, S.3    Nebert, D.W.4
  • 38
    • 0022483558 scopus 로고
    • Complementary DNA and amino acid sequence of rat liver microsomal, xenobiotic epoxide hydrolase
    • Porter, T. D., Beck, T. W., and Kasper, C. B. Complementary DNA and amino acid sequence of rat liver microsomal, xenobiotic epoxide hydrolase. Arch. Biochem. Biophys., 248: 121–129, 1986.
    • (1986) Arch. Biochem. Biophys. , vol.248 , pp. 121-129
    • Porter, T.D.1    Beck, T.W.2    Kasper, C.B.3
  • 39
    • 0024333259 scopus 로고
    • Phenobarbital-inducible aldehyde dehydrogenase in the rat
    • Dunn, T. J., Koleske, A. J., Lindahl, R., and Pitot, H. C. Phenobarbital-inducible aldehyde dehydrogenase in the rat. J. Biol. Chem., 264: 13057–13065, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 13057-13065
    • Dunn, T.J.1    Koleske, A.J.2    Lindahl, R.3    Pitot, H.C.4
  • 40
    • 0022602551 scopus 로고
    • Characterization and sequence of a cDNA clone of γ-glutamyltranspeptidase
    • Coloma, J., and Pitot, H. C. Characterization and sequence of a cDNA clone of γ-glutamyltranspeptidase. Nucleic Acids Res., 14: 1393–1403, 1986.
    • (1986) Nucleic Acids Res. , vol.14 , pp. 1393-1403
    • Coloma, J.1    Pitot, H.C.2
  • 42
    • 0026730368 scopus 로고
    • Induction of a pleiotropic response by phenobarbital and related compounds. Responses in various inbred strains of rats, responses in various species and the induction of aldehyde dehydrogenase in Copenhagen rats
    • Jones, C. R., and Lubet, R. A. Induction of a pleiotropic response by phenobarbital and related compounds. Responses in various inbred strains of rats, responses in various species and the induction of aldehyde dehydrogenase in Copenhagen rats. Biochem. Pharmacol., 44: 1651–1660, 1992.
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 1651-1660
    • Jones, C.R.1    Lubet, R.A.2
  • 43
    • 0021956572 scopus 로고
    • Phenobarbital induction of rat liver cytochromes P450b and P450e
    • Omiecinski, C. J., Walz, F. G., and Vlasuk, G. P. Phenobarbital induction of rat liver cytochromes P450b and P450e. J. Biol. Chem., 260: 3247–3250, 1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 3247-3250
    • Omiecinski, C.J.1    Walz, F.G.2    Vlasuk, G.P.3
  • 44
    • 0021961725 scopus 로고
    • Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium, and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine
    • Diwan, B. A., Rice, J. M., Ohshima, M., Ward, J. M., and Dove, L. F. Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium, and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine. J. Natl. Cancer Inst., 74: 509–515, 1985.
    • (1985) J. Natl. Cancer Inst. , vol.74 , pp. 509-515
    • Diwan, B.A.1    Rice, J.M.2    Ohshima, M.3    Ward, J.M.4    Dove, L.F.5
  • 45
    • 0023194543 scopus 로고
    • Induction of aloxyresorufin 0-dealkylase, epoxide hydrolase, and liver weight gain: correlation with liver tumor-promoting potential in a series of barbiturates
    • Nims, R. W., Devor, D. E., Henneman, J. R., and Lubet, R. A. Induction of aloxyresorufin 0-dealkylase, epoxide hydrolase, and liver weight gain: correlation with liver tumor-promoting potential in a series of barbiturates. Carcinogenesis (Lond.), 8: 67–71, 1987.
    • (1987) Carcinogenesis (Lond.) , vol.8 , pp. 67-71
    • Nims, R.W.1    Devor, D.E.2    Henneman, J.R.3    Lubet, R.A.4
  • 46
    • 0020363333 scopus 로고
    • A comparative study of the efficacy of four barbiturates as promoters of the development of y-glutamyltranspeptidase-positive foci in the liver of carcinogen treated rats
    • Shinozuka, H., Lombardi, B., and Adanobi, S. E. A comparative study of the efficacy of four barbiturates as promoters of the development of y-glutamyltranspeptidase-positive foci in the liver of carcinogen treated rats. Carcinogenesis (Lond.), 3: 1017–1020, 1982.
    • (1982) Carcinogenesis (Lond.) , vol.3 , pp. 1017-1020
    • Shinozuka, H.1    Lombardi, B.2    Adanobi, S.E.3
  • 48
    • 0026065862 scopus 로고
    • Synthetic estrogens and tamoxifen as promoters of hepatocarcinogenesis
    • Yager, J. D., and Shi, Y. E. Synthetic estrogens and tamoxifen as promoters of hepatocarcinogenesis. Prev. Med., 20: 27–37, 1991.
    • (1991) Prev. Med. , vol.20 , pp. 27-37
    • Yager, J.D.1    Shi, Y.E.2
  • 51
    • 0023187175 scopus 로고
    • Suppression of levels of phenobarbital-inducible rat liver cytochrome P450 by pituitary hormone
    • Yamazoe, Y., Shimada, M., Murayama, N., and Kato, R. Suppression of levels of phenobarbital-inducible rat liver cytochrome P450 by pituitary hormone. J. Biol. Chem., 262: 7423–7428, 1987.
    • (1987) J. Biol. Chem. , vol.262 , pp. 7423-7428
    • Yamazoe, Y.1    Shimada, M.2    Murayama, N.3    Kato, R.4
  • 52
    • 0025156936 scopus 로고
    • Selective induction of cytochrome P450 isozymes in rat liver by 4-n-alkyl-methyl-enedioxybenzenes
    • Marcus, C. B., Wilson, N. M., Jefcoate, C. R., Wilkinson, C. F., and Omiecinski, C. J. Selective induction of cytochrome P450 isozymes in rat liver by 4-n-alkyl-methyl-enedioxybenzenes. Arch. Biochem. Biophys., 277: 8–16, 1990.
    • (1990) Arch. Biochem. Biophys. , vol.277 , pp. 8-16
    • Marcus, C.B.1    Wilson, N.M.2    Jefcoate, C.R.3    Wilkinson, C.F.4    Omiecinski, C.J.5
  • 53
    • 0026672926 scopus 로고
    • Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital
    • Honkoski, P., Kojo, A., and Lang, M. A. Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital. Biochem. J., 285: 979–983, 1992.
    • (1992) Biochem. J. , vol.285 , pp. 979-983
    • Honkoski, P.1    Kojo, A.2    Lang, M.A.3
  • 54
    • 0026728537 scopus 로고
    • Tamoxifen attenuates pulsatile growth hormone secretion: mediation in part by somatostatin
    • Tannenbaum, G. S., Gurd, W., Lapointe, M., and Pollak, M. Tamoxifen attenuates pulsatile growth hormone secretion: mediation in part by somatostatin. Endocrinology, 130: 3395–3401, 1992.
    • (1992) Endocrinology , vol.130 , pp. 3395-3401
    • Tannenbaum, G.S.1    Gurd, W.2    Lapointe, M.3    Pollak, M.4
  • 55
    • 0026572698 scopus 로고
    • Direct effects of tamoxifen on growth hormone secretion by pituitary cells in vitro
    • Malaab, S. A., Pollak, M. N., and Goodyer, C. G. Direct effects of tamoxifen on growth hormone secretion by pituitary cells in vitro. Eur. J. Cancer, 28A: 788–793, 1992.
    • (1992) Eur. J. Cancer , vol.28A , pp. 788-793
    • Malaab, S.A.1    Pollak, M.N.2    Goodyer, C.G.3
  • 56
    • 0017646557 scopus 로고
    • Alterations in drug metabolism in workers exposed to polychlorinated biphenyls
    • Alvares, A. P., Fischbein, A., Anderson, K. E., and Kappas, A. Alterations in drug metabolism in workers exposed to polychlorinated biphenyls. Clin. Pharmacol. Ther., 22: 141–146, 1977.
    • (1977) Clin. Pharmacol. Ther. , vol.22 , pp. 141-146
    • Alvares, A.P.1    Fischbein, A.2    Anderson, K.E.3    Kappas, A.4
  • 57
    • 0020654228 scopus 로고
    • Enzyme-inducing drug combinations and their effects on liver microsomal enzyme activity in man
    • Ohnhaus, E. E., Gerber-Taras, E., and Park, B. K. Enzyme-inducing drug combinations and their effects on liver microsomal enzyme activity in man. Eur. J. Clin. Pharmacol., 24: 247–250, 1983.
    • (1983) Eur. J. Clin. Pharmacol. , vol.24 , pp. 247-250
    • Ohnhaus, E.E.1    Gerber-Taras, E.2    Park, B.K.3
  • 60
    • 0024535104 scopus 로고
    • Urinary excretion of 6β-hydroxycortisol and the time course measurement of enzyme induction in man
    • Ohnhaus, E. E., Breckenridge, A. M., and Park, B. K. Urinary excretion of 6β-hydroxycortisol and the time course measurement of enzyme induction in man. Eur. J. Clin. Pharmacol., 36: 39–46, 1989.
    • (1989) Eur. J. Clin. Pharmacol. , vol.36 , pp. 39-46
    • Ohnhaus, E.E.1    Breckenridge, A.M.2    Park, B.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.