Atherosclerosis: Basic mechanisms: Oxidation, inflammation, and genetics

Circulation

Volumn 91, Issue 9, 1995, Pages 2488-2496

  Berliner, Judith A ^a,b   Navab, Mohamad ^a   Fogelman, Alan M ^a   Frank, Joy S ^a,b   Demer, Linda L ^a,b   Edwards, Peter A ^a,b   Watson, Andrew D ^b   Lusis, Aidons J ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Department of Medical Pharmacology   (United States)

Author keywords

antioxidants; atherosclerosis; genes; lipids; lipoproteins

Indexed keywords

GENE PRODUCT; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; THROMBOPLASTIN; TRANSCRIPTION FACTOR;

ARTERY CALCIFICATION; ARTERY WALL; ATHEROSCLEROTIC PLAQUE; EXTRACELLULAR MATRIX; GENE ACTIVATION; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; HUMAN; INFLAMMATION; LIPID OXIDATION; PRIORITY JOURNAL; REVIEW; THROMBOSIS; VASCULAR ENDOTHELIUM;

EID: 0028925078     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.91.9.2488     Document Type: Review

References (127)

1. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med. 1992;326:242-250,310-318.
2. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol: modifications of low density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915-924.
3. Young SG, Parthasarathy S. Why are low density lipoproteins atherogenic? West J Med. 1994;160:153-164.
4. Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science. 1986;232:34-47.
5. Schwenke DC, Carew TE. Initiation of atherosclerotic lesions in cholesterol-fed rabbits, I: focal increases in arterial LDL concentrations precede development of fatty streak lesions. Arteriosclerosis. 1989;9:895-907.
6. Schwenke DC, Carew TE. Initiation of atherosclerotic lesions in cholesterol-fed rabbits, II: selective retention of LDL vs selective increases in LDL permeability in susceptible sites of arteries. Arteriosclerosis. 1989;9:908-918.
7. Kruth HS. Subendothelial accumulation of unesterified cholesterol: an early event in the atherosclerotic lesion development. Atherosclerosis. 1985;57:337-341.
8. Simionescu N, Vasile E, Lupu F, Popescu G, Simionescu M. Prelesional events in atherogenesis: accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit. Am J Pathol. 1986;123:1109-1125.
9. Frank JS, Fogelman AM. Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching. J Lipid Res. 1989;30:967-978.
10. Nievelstein PFEM, Fogelman AM, Mottino G, Frank JS. Lipid accumulation in rabbit aortic intima 2 hours after bolus infusion of low density lipoprotein: a deep-etch and immunolocalization study of rapidly frozen tissue. Arterioscler Thromb. 1991;11:1795-1805.
11. Nivelstein-Post P, Mottino G, Fogelman A, Frank J. An ultrastructural study of lipoprotein accumulation in cardiac valves of the rabbit. Arterioscler Thromb. 1994;14:1151-1161.
12. Smith EB. The relationship between plasma and tissue lipids in human atherosclerosis. Adv Lipid Res. 1974;12:1-49.
13. Hoff HF, Heideman CL, Gaubatz JW, Gotto AM Jr, Erickson EE, Jackson RL. Quantification of apolipoprotein B in grossly normal human aorta. Circ Res. 1977;40:56-64.
14. Hoff HF, Heideman CL, Gotto AM Jr, Gaubatz JW. Apolipoprotein B retention in the grossly normal and atherosclerotic human aorta. Circ Res. 1977;41:684-690.
15. Gerrity RG. The role of the monocyte in atherogenesis, I: transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol. 1981;103:181-190.
16. Cornhill JF, Herderick EE, Stary HC. Topography of human sudanophilic lesions. Monogr Atheroscler. 1990;15:13-29.
17. Gerrity RG, Schwartz CJ. Structural correlates of arterial endothelial permeability in the Evans blue model. Prog Biochem Pharmacol. 1977;14:134-137.
18. Gerrity RG, Naito HK, Richardson M, Schwartz CJ. Dietary induced atherogenesis in swine. Am J Pathol. 1979;95:775-793.
19. Gerrity RG. The role of the monocyte in atherogenesis, II: migration of foam cells from atherosclerotic lesions. Am J Pathol. 1981;103:191-200.
20. Masuda J, Ross R. Atherogenesis during low level hypercholesterolemia in the nonhuman primate, I: fatty streak formation. Arteriosclerosis. 1990;10:164-177.
21. Masuda J, Ross R. Atherogenesis during low level hypercholesterolemia in the nonhuman primate, II: fatty streak conversion to fibrous plaque. Arteriosclerosis. 1990;10:178-187.
22. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) research group. Natural history of aortic and coronary atherosclerotic lesions in youth: findings from the PDAY study. Arterioscler Thromb. 1993;13:1291-1298.
23. Mehrabian M, Demer LL, Lusis AJ. Differential accumulation of intimai monocyte-macrophages relative to lipoproteins and lipofuscin corresponds to hemodynamic forces on cardiac valves in mice. Arterioscler Thromb. 1991;11:947-957.
24. Demer LL, Wortham CM, Dirksen ER, Sanderson MJ. Mechanical stimulation induces intercellular calcium signaling in bovine aortic endothelial cells. Am J Physiol. 1993;264:H2094-H2102.
25. Resnick N, Collins T, Atkinson W, Bonthron DT, Dewey CF Jr, Gimbrone MA Jr. Platelet-derived growth factor B chain promoter contains a cis acting fluid shear-stress-responsive element. Proc Natl Acad Sci U S A. 1993;90:4591-4595 [erratum appears in Proc Natl Acad Sci USA. 1993;90:7908].
26. Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 1991;88:1785-1792.
27. Parthasarathy S. Modified Lipoproteins in the Pathogenesis of Atherosclerosis. Austin, Tex: RG Landes Co; 1994:91-119.
28. Parthasarathy S. Mechanism(s) of cell-mediated oxidation of low density lipoprotein. In: Nohl H, Esterbauer H, Rice Evans C, eds. Free Radicals in the Environment, Medicine and Toxicology. London, England: Richelieu Press; 1994:163-179.
29. Witztum JL. The oxidation hypothesis of atherosclerosis. Lancet. 1994;344:793-795.
30. Navab M, Imes SS, Hama SY, Hough GP, Ross LA, Bork RW, Valente AJ, Berliner JA, Drinkwater DC, Laks H, Fogelman AM. Monocyte transmigration induced by modification of low density lipoprotein in co-cultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. J Clin Invest. 1991; 88:2039-2046.
31. Fogelman AM, Shechter I, Seager J, Hokom M, Child JS, Edwards PA. Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. Proc Natl Acad Sci U S A. 1980; 77:2214-2218.
32. Henricksen T, Mahoney EM, Steinberg D. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptor for acetylated low density lipoproteins. Proc Natl Acad Sci U S A. 1981; 78:6499-6503.
33. Morel DW, DiCorleto PE, Chisolm GM. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis. 1984;4:357-364.
34. Steinbrecher U, Parthasarathy S, Leake DS, Witztum JL, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci U S A. 1984;83:3883-3887.
35. Heinecke JW, Rosen H, Chait A. Iron and copper promote modification of LDL by human arterial smooth muscle cells. J Clin Invest. 1984;74:1890-1894.
36. Haberland ME, Fong D, Cheng L. Malondialdehyde altered protein occurs in atheroma of WHHL rabbits. Science. 1988; 241:215-218.
37. Palinski W, Rosenfeld ME, Yla-Herttuala S, Gurtner GC, Socher SS, Butler SW, Parthasarathy S, Carew TE, Steinberg D, Witztum JL. LDL undergoes oxidative modification in vivo. Proc Natl Acad Sci U S A. 1989;86:1372-1380.
38. Yla-Herttuala S, Palinski W, Rosenfeld S, Parthasarathy S, Carew TE, Butler S, Witztum JL, Steinberg D. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest. 1989;84:1086-1095.
39. Haberland ME, Steinbrecher UP. Modified low density lipoproteins: diversity and biologic relevance in atherosclerosis. In: Lusis AJ, Rotter JI, Sparkes RS, eds. Molecular Genetics of Coronary Artery Disease. 1992:35-61.
40. Brown MS, Goldstein JL. Scavenging for receptors. Nature. 1990;343:508-509.
41. Freeman M, Ashkenas J, Rees DJ, Kingsley DM, Copeland NG, Jenkins NA, Krieger M. An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci U S A. 1990;87:8810-8814.
42. Sparrow CP, Parthasarathy S, Steinberg D. A macrophage receptor that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein. J Biol Chem. 1989; 264:2599-2604.
43. Berliner JA, Territo MC, Sevanian A, Ramin S, Kim JA, Bamshad B, Esterson M, Fogelman AM. Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest. 1990;85:1260-1266.
44. McEver RP. Leukocyte-endothelial interactions. Curr Opin Cell Biol. 1992;4:840-849.
45. Vora DK, Fang ZT, Parhami F, Fogelman AM, Territo MC, Berliner JA. P-selectin induction by MM-LDL and its expression in human atherosclerotic lesions. Circulation. 1994;90:I-83. Abstract.
46. Lehr HA, Hubner D, Nolle B, Finckh B, Beieigel U, Kohlschutter A, Messmer K. Oxidatively modified human LDL stimulates leukocyte adherence to the microvascular endothelium in vivo. Res Exp Med (Berl). 1991;191:85-90.
47. Johnson RR, McGregor L, Taylor RN, Poston RN. Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques: coexpression with intercellular adhesion molecule-1. Am J Pathol. 1994;144:952-961.
48. Cushing SD, Berliner JA, Valente AJ, Territo MC, Navab M, Parhami F, Gerrity R, Schwartz CJ, Fogelman AM. Minimally modified LDL induces monocyte chemotactic protein 1 in human endothelial and smooth muscle cells. Proc Natl Acad Sci U S A. 1990;87:5134-5138.
49. Rajavashisth TB, Andalibi A, Territo MC, Berliner JA, Navab M, Fogelman AM, Lusis AJ. Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low density lipoproteins. Nature. 1990;344:254-257.
50. Schwartz D, Chaverri-Almada L, Berliner JA, Kirchgessenr T, Quismorio DC, Fang ZT, Tekamp-Olson P, Lusis AJ, Fogelman AM, Territo MC. The role of a gro homologue in monocyte adhesion to endothelium. J Clin Invest. 1994;94:1968-1973.
51. Li H, Cybulsky MI, Gimbrone MA Jr, Libby PA. An atherogenic diet rapidly induces VCAM-1, a cytokine regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb. 1993;13:197-204.
52. Kim JA, Territo MC, Wayner E, Carlos TM, Parhami F, Smith CW, Haberland ME, Fogelman AM, Berliner JA. Partial characterization of leukocyte binding molecules on endothelial cells induced by minimally oxidized LDL. Arterioscler Thromb. 1994;14:427-433.
53. Clinton SK, Underwood R, Hayes L, Sherman ML, Kufe DW, Libby P. M-CSF gene expression in vascular cells and in experimental and human atherosclerosis. Am J Pathol. 1992;140:301-316.
54. Yla-Herttuala S, Lipton BA, Rosenfeld ME, Sarkioja T, Yoshimura T, Leonard EJ, Witztum JL, Steinberg D. Expression of monocyte chemoattractant protein 1 in macrophage rich areas of human and rabbit atherosclerotic lesions. Proc Natl Acad Sci U S A. 1991;88:5252-5256.
55. Cushing SD, Fogelman AM. Monocytes may amplify their recruitment into inflammatory lesions by inducing monocyte chemotactic protein. Arterioscler Thromb. 1992;12:78-82.
56. Neiken NA, Coughlin SR, Gordon D, Wilcox JN. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest. 1991;88:1121-1127.
57. Charo IF, Myers SJ, Herman A, Franci C, Connolly AJ, Coughlin SR. Molecular cloning and functional expression of two monocyte chemoattractant 1 protein receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci U S A. 1994; 91:2752-2756.
58. Parhami F, Fang ZT, Fogelman AM, Andalibi A, Territo MC, Berliner JA. Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. J Clin Invest. 1993;92:471-478.
59. Bork RW, Svenson KL, Mehrabian M, Lusis AJ, Fogelman AM, Edwards PA. Mechanisms controlling competence gene expression in murine fibroblasts stimulated with minimally modified LDL. Arterioscler Thromb. 1992;12:800-806.
60. Hessler JR, Roberston AL Jr, Chisolm GM. LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture. Atherosclerosis. 1979; 32:213-229.
61. Parthasarathy S, Barnett J, Fong LG. High density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochim Biophys Acta. 1990;1044:275-283.
62. Hama SY, Navab M, de Beer FC, Fogelman AM. Acute-phase high density lipoprotein does not prevent but amplifies the modification of low density lipoprotein. Circulation. 1992;86:I-423. Abstract.
63. Stafforini DM, Zimmerman GA, McIntyre TM, Prescott SM. The platelet activating factor acetylhydrolase from human plasma prevents oxidative modification of low density lipoprotein. Trans Am Assoc Physiol. 1993;106:44-63.
64. Mackness MI, Arrol S, Durrington PN. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett. 1991;286:152-154.
65. Watson AD, Navab M, Hama SY, Sevanian A, Prescott SM, Stafforini DM, McIntyre TM, La Du BN, Fogelman AM, Berliner JA. Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized-low density lipoprotein. J Clin Invest. 1995;95:774-782.
66. Watson AD, Navab M, Hough GP, Hama SY, La Du BN, Young L, Laks H, Permut LC, Fogelman AM, Berliner JA. Biologically active phospholipids in MM-LDL are transferred to HDL and are hydrolyzed by HDL-associated esterases. Circulation. 1994;90: I-353. Abstract.
67. Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Jacobs JD Jr, Bangdiwala S, Tyroler HA. High-density lipoprotein cholesterol and cardiovascular disease. Circulation. 1989;79:8-15.
68. Navab M, Liao F, Hough GP, Ross LA, Van Lenten BJ, Rajavashisth TB, Lusis AJ, Laks H, Drinkwater DC, Fogelman AM. Interaction of monocytes with co-cultures of human aortic wall cells involves interleukins 1 and 6 with marked increases in connexin43 message. J Clin Invest. 1991;87:1763-1772.
69. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
70. Ku G, Thoma CA, Akeson AL, Jackson RL. Induction of interleukin 1 beta expression from human periperal blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid. J Biol Chem. 1992;267:14183-14188.
71. Quinn MT, Parthasarathy S, Steinberg D. Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. Proc Natl Acad Sci U S A. 1988; 85:2805-2809.
72. McMurray HF, Parthasarathy S, Steinberg D. Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes. J Clin Invest. 1993;92:1004-1008.
73. Kume N, Cybulsky MI, Gimbrone MA Jr. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest. 1992;90:1138-1144.
74. Kume N, Gimbrone MA Jr. Lysophophatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells. J Clin Invest. 1994;93:907-911.
75. Nakano T, Raines EW, Abraham JA, Klagsburn M, Ross R. Lysophosphatidylcholine induces monocyte expression of heparin binding EGF-like growth factor mRNA. J Cell Biochem Suppl. 4992;16:18. Abstract.
76. Murugesan G, Chisolm GM, Fox PL. Oxidized low density lipoprotein inhibits the migration of aortic endothelial cells in vitro. J Cell Biol. 1993;120:1011-1019.
77. Reid VC, Mitchinson MJ. Toxicity of oxidized low density lipoprotein towards mouse peritoneal macrophages in vitro. Atherosclerosis. 1993;98:17-24.
78. Wolfbauer G, Glick JM, Minor LK, Rothblat GH. Development of the smooth muscle foam cell: uptake of macrophage lipid inclusions. Proc Natl Acad Sci U S A. 1986;83:7760-7764.
79. Hansson GK, Holm J, Jonasson L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol. 1989;135:169-175.
80. Stemme S, Holm J, Hansson GK. T lymphocytes in human atherosclerotic plaques are memory cells expressing CD45R0 and the integrin VLA-1. Arterioscler Thromb. 1992;12:1258-1266.
81. Libby P, Hansson GK. Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions. Lab Invest. 1991;64:5-15.
82. Qiao J-H, Castellani LW, Fishbein MC, Lusis AJ. Immune-complex-mediated vasculitis increases coronary artery lipid accumulation in autoimmune-prone MRL mice. Arterioscler Thromb. 1993;13:932-943.
83. Fyfe AI, Qiao J-H, Lusis AJ. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet, J Clin Invest. 1994;94:2516-2520.
84. Palinski W, Miller E, Witztum JL. Immunization of LDL receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc Natl Acad Sci U S A. 1995; 92:821-825.
85. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371-1375.
86. Rosenfeld ME, Tsukada T, Chait A, Bierman EL, Gown AL, Ross R. Fatty streak expansion and maturation in Watanabe heritable hyperlipidemic and comparable hypercholesterolemic fat-fed rabbits. Arteriosclerosis. 1987;7:24-34.
87. Ross R. Atherosclerosis: a defense mechanism gone awry. Am J Pathol. 1993;143:987-1002. Rous-Whipple Award Lecture.
88. Reidy MA. Growth factors and arterial smooth muscle cell proliferation. Ann N Y Acad Sci. 1994;714:225-230.
89. Riessen R, Isner JM, Blessing E, Loushin C, Nikol S, Wight TN. Regional differences in the distribution of the proteoglycans biglycan and decorin in the extracellular matrix of atherosclerotic and restenotic human coronary arteries. Am J Pathol. 1994; 144:962-974.
90. Guyton JR, Klemp KF. The lipid-rich core region of human atherosclerotic fibrous plaques. Am J Pathol. 1989;134:705-717.
91. Liao F, Andalibi A, deBeer FC, Fogelman AM, Lusis AJ. Genetic control of inflammatory gene induction and NFκB-like transcription factor activation in response to an atherogenic diet in mice. J Clin Invest. 1993;91:2572-2579.
92. Qiao J-H, Welch CL, Xie P-Z, Fishbein MC, Lusis AJ. Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice: association with aortic fatty streak development. J Clin Invest. 1993;92:2386-2393.
93. Liao F, Lusis AJ, Berliner JA, Fogelman AM, Kindy M, de Beer MC, de Beer FC. Serum amyloid A protein family: differential induction by oxidized lipids in mouse strains. Arterioscler Thromb. 1994;14:1475-1479.
94. Andalibi A, Liao F, Imes S, Fogelman AM, Lusis AJ. Oxidized lipoproteins influence gene expression by causing oxidative stress and activating the transcription factor NFκB. Biochem Soc Trans. 1993;21:651-655.
95. Liao F, Andalibi A, Qiao J-H, Allayee H, Fogelman AM, Lusis AJ. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice. J Clin Invest. 1994;94:877-884.
96. van der Wal AC, Becker AE, van der Loos CM, Das P. Site of intimai rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 1994;89:36-44.
97. Buja LM, Willerson JT. Role of inflammation in coronary plaque disruption. Circulation. 1994;89:503-505.
98. Demer LL. Effect of calcification on in vivo mechanical response of rabbit arteries to balloon dilation. Circulation. 1991; 83:2083-2093.
99. Demer LL, Watson KE, Bostrom K. Mechanism of calcification in atherosclerosis. Trends Cardiovasc Med. 1994;4:45-49.
100. Bostrom K, Watson KE, Horn S, Wortham C, Herman IM, Demer LL. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. 1993;91:1800-1809.
101. Watson KE, Bostrom K, Ravindranath R, Lam T, Norton B, Demer LL. TGF-β1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest. 1994; 93:2106-2113.
102. Beadenkopf WG, Daoud AS, Love BM. Calcification in the coronary arteries and its relationship to arteriosclerosis and myocardial infarction. Am J Roentgenol. 1964;92:865-871.
103. Fitzgerald PJ, Ports TA, Yock PG. Contribution of localized calcium deposits to dissection after angioplasty: an observational study using intravascular ultrasound. Circulation. 1992;86:64-70.
104. Sharma SK, Israel DH, Kamean JL, Bodian CA, Ambrose JA. Clinical, angiographie, and procedural determinants of major and minor coronary dissection during coronary angioplasty. Am Heart J. 1993;126:39-47.
105. Kragel AH, Reddy SG, Wittes JT, Roberts WC. Morphometric analysis of the composition of atherosclerotic plaques in the four major epicardial coronary arteries in acute myocardial infarction and in sudden coronary death. Circulation. 1989;80:1747-1756.
106. Kragel, AH, Reddy SG, Wittes JT, Roberts WC. Morphometric analysis of the composition of coronary arterial plaques in isolated unstable angina pectoris with pain at rest. Am J Cardiol. 1990;66:562-567.
107. Qiao J-H, Xie P-Z, Fishbein MC, Kreuzer J, Drake TA, Demer LL, Lusis AJ. Pathology of atheromatous lesions in inbred and genetically engineered mice: genetic determination of arterial calcification. Arterioscler Thromb. 1994;14:1480-1497.
108. Henny AM, Wakeley PR, Davies MJ, Foster K, Hembry R, Murphy G, Humphries S. Location of stromelysin gene in atherosclerotic plaques using in situ hybridization. Proc Natl Acad Sci U S A. 1991;88:8154-8158.
109. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994;94:2493-2503.
110. Drake TA, Hannani K, Fei H, Lavi S, Berliner JA. Minimally oxidized low-density lipoprotein induces tissue factor expression in cultured human endothelial cells. Am J Pathol. 1991;138:601-607.
111. Fei H, Berliner JA, Parhami F, Drake TA. Regulation of endothelial tissue factor expression by minimally oxidized LDL and lipopolysaccharide. Arterioscler Thromb. 1993;13:1711-1717.
112. Brand L, Banka CL, Madmann N, Terkeltaub RA, Fan ST, Curtiss LK. Oxidized LDL enhances lipopolysaccharide-induced tissue factor expression in human adherent monocytes. Arterioscler Thromb. 1994;14:790-797.
113. Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues: implications for disorders of hemostasis and thrombosis. Am J Pathol. 1989; 134:1087-1097.
114. Latron Y, Chautan M, Anfosso F, Alessi MC, Nalbone G, Lafont H, Juhan-Vague I. Stimulating effect of oxidized low density lipoproteins on plasminogen activator inhibitor-1 synthesis by endothelial cells. Arterioscler Thromb. 1991;11:1821-1829.
115. Vanhoutte PM. Endothelium and control of vascular function. Hypertension. 1989;13:658-667. State of the Art Lecture.
116. Boulanger CM, Tanner FC, Bea ML, Hahn AW, Werner A, Luscher F. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium. Circ Res. 1992;70:1191-1197.
117. Galle J, Bassenge E, Busse R. Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle. Circ Res. 1990;66: 1287-1293.
118. Mangin EL Jr, Kugiyama K, Nguy JH, Kerns SA, Henry PD. Effects of lysolipids and oxidatively modified low density lipoprotein on endothelium-dependent relaxation of rabbit aorta. Circ Res. 1993;72:161-166.
119. Yang X, Cai B, Sciacca RR, Cannon PJ. Inhibition of inducible nitric oxide synthase in macrophages by oxidized low-density lipoproteins. Circ Res. 1994;74:318-328.
120. Willerson JT, Golino P, Eidt J, Campbell WB, Buja LM. Specific platelet mediators and unstable coronary artery lesions: experimental evidence and potential clinical implications. Circulation. 1989;80:198-205.
121. Fuster V, Lewis A. Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation. 1994;90: 2126-2146. Conner Memorial Lecture.
122. Palinski W, Ord VA, Plump AS, Breslow JL, Steinberg D, Witztum JL. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis: demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler Thromb. 1994; 14:605-616.
123. Cathcart MK, McNally AK, Chisolm GM. Lipoxygenase-mediated transformation of human low density lipoprotein to an oxidized and cytotoxic complex. J Lipid Res. 1991;32:63-70.
124. Roach TIA, Barton CH, Chatterjee D, Blackwell JM. Macrophage activation: lipoarabinomannan from avirulent and virulent strains of mycobacterium tuberculosis differentially induces the early genes c-fos, KC, JE, and tumor necrosis factor-α. J Immunol. 1993;150:1886-1896.
125. Lusis AJ, Navab M. Lipoprotein oxidation and gene expression in the artery wall: new opportunities for pharmacologic intervention in atherosclerosis. Biochem Pharmacol. 1993;46:2119-2126.
126. Navab M, Hama SY, Van Lenten BJ, Drinkwater DC, Laks H, Fogelman AM. A new antiinflammatory compound, leumedin, inhibits modification of low density lipoprotein and the resulting monocyte transmigration into the subendothelial space of cocultures of human artery wall cells. J Clin Invest. 1993; 91:1225-1230.
127. Bennett RL, Navab M, Demer LL, Fogelman AM. A new antiinflammatory leucine derivative, NPC-15669, inhibits growth of cultured human aortic smooth muscle cells. Arterioscler Thromb. 1993;13:360-366.