Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2

Journal of Clinical Investigation

Volumn 95, Issue 4, 1995, Pages 1861-1868

  Wilborn, Jerome ^a   Crofford, Leslie J ^a   Burdick, Marie D ^a   Kunkel, Steven L ^a   Strieter, Robert M ^a   Peters Golden, Marc ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

arachidonic acid; eicosanoids; interleukin 1 ; lipopolysaccharide; prostaglandin H synthase

Indexed keywords

ARACHIDONIC ACID; ICOSANOID; INTERLEUKIN 1BETA; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FIBROBLAST CULTURE; FIBROGENESIS; HUMAN; HUMAN TISSUE; INFLAMMATION; LUNG FIBROSIS; LUNG RESECTION; MALE; METABOLIC REGULATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; REGULATORY MECHANISM;

EID: 0028924146     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117866     Document Type: Article

References (44)

1. Panos, R., and T. King. 1991. Idiopathic pulmonary fibrosis. In Immunologically Mediated Pulmonary Diseases. J. P. Lynch III and R. A. DeRemee, editors. J. B. Lippincott, Philadelphia, PA. 1-39.
2. Jordana, M., M. Newhouse, and J. Gauldie. 1987. Alveolar macrophage-and peripheral blood monocyte-derived factors modulate proliferation of primary lines of human lung fibroblasts. J. Leukocyte Biol. 42:51-60.
3. Elias, J., B. Freundlich, J. Kern, and J. Rosenbloom. 1990. Cytokine networks in the regulation of inflammation and fibrosis in the lung. Chest. 97:1439-1445.
4. Gauldie, J., M. Jordana, and G. Cox. 1994. Cytokines and pulmonary fibrosis. Cytokines. 4:931-935.
5. Clark, J., D. Madtes, and G. Raghu. 1993. Effects of platelet-derived growth factor isoform on human lung fibroblast proliferation and collagen gene expression. Exp. Lung Res. 19:327-344.
6. Fine, A., and R. Goldstein. 1986. The effect of transforming growth factor-β on cell proliferation and collagen formation by lung fibroblasts. J. Biol. Chem. 262:3897-3902.
7. Elias, J., M. Rossman, R. Zurier, and R. Daniele. 1985. Human alveolar macrophage inhibition of lung fibroblast growth: a prostaglandin-dependent process. Am. Rev. Respir. Dis. 131:94-99.
8. Bitterman, P., M. Wewers, S. Rennard, S. Adelberg, and R. Crystal. 1986. Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators. J. Clin. Invest. 77:700-708.
9. Elias, J. 1988. Tumor necrosis factor interacts with interleukin-1 and interferons to inhibit fibroblast proliferation via prostaglandin-dependent and independent mechanisms. Am. Rev. Respir. Dis. 138:652-658.
10. Goldstein, R., and P. Polgar. 1982. The effect and interaction of bradykinin and prostaglandins on protein and collagen production by lung fibroblasts. J. Biol. Chem. 257:8630-8633.
11. Korn, J., P. Halushka, and E. Leroy. 1980. Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production. J. Clin. Invest. 65:543-554.
12. Baum, B., S. Moss, R. Breul, and R. Crystal. 1980. Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen. J. Biol. Chem. 255:2843-2847.
13. Levine, L., and I. Alam. 1979. Arachidonic acid metabolism by cells in culture: analyses of culture fluids for cyclooxygenase products by radioimmunoassay before and after separation by high pressure liquid chromatography. Prostaglandins Med. 3:295-304.
14. 2 synthesis. J. Clin. Invest. 71:1240-1246.
15. Shindo, N., T. Saito, and K. Murayama. 1988. Rapid quantification of 11 prostanoids by combined capillary column gas chromatography and negative ion chemical ionization mass spectrometry: application to prostanoids released from normal human embryonic lung fibroblasts WI38 in a culture medium. Biomed. Environ. Mass. Spec. 15:25-32.
16. Smith, W., and L. Marnett. 1991. Prostaglandin endoperoxide synthase: structure and catalysis. Biochem. Biophys. Acta. 1083:1-17.
17. O'Neill, G., and A. Ford-Hutchinson. 1993. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS (Fed Eur. Biochem. Soc.) Lett. 330:156-160.
18. 2 synthase (cyclooxygenase) in human monocytes. J. Biol. Chem. 265:16737-16740.
19. Jones, D., P. Carlton, T. McIntyre, G. Zimmerman, and S. Prescott. 1993. Molecular cloning of human prostaglandin endoperoxide synthase type 2 and demonstration of expression in response to cytokines. J. Biol. Chem. 268:9049-9054.
20. Masferrer, J., K. Siebert, B. Zweifel, and P. Needleman. 1992. Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme. Proc. Natl. Acad. Sci. USA. 89:3917-3921.
21. Kujubu, D., S. Reddy, B. Fletcher, and H. Herschman. 1993. Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells. J. Biol. Chem. 268:5425-5430.
22. Watters, L., T. King, M. Schwarz, J. Waldron, R. Stanford, and M. Reuben. 1986. A clinical, radiographic, and physiologic scoring system for the longitudinal assessment of patients with idiopathic pulmonary fibrosis. Am. Rev. Respir. Dis. 133:97-103.
23. Rolfe, M., S. Kunkel, T. Standiford, S. Chensue, R. Allen, H. Evanoff, S. Phan, and R. Strieter. 1992. Pulmonary fibroblast expression of interleukin-8: a model for alveolar macrophage-derived cytokine networking. Am. J. Respir. Cell. Mol. Biol. 5:493-501.
24. Peters-Golden, M., R. W. McNish, R. Hyzy, C. Shelly, and G. B. Toews. 1990. Alterations in the pattern of arachidonate metabolism accompany rat macrophage differentiation in the lung. J. Immunol. 144:263-270.
25. Bradford, M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
26. Laemmli, U. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:680-685.
27. Meade, E., W. Smith, and D. DeWitt. 1993. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268:6610-6614.
28. Smith, W., and T. Rollins. 1982. Characteristics of rabbit anti-PGH synthase antibodies and use in immunochemistry. Methods Enzymol. 86:213-222.
29. O'Sullivan, M., E. Huggins, Jr., E. Meade, D. DeWitt, and C. McCall. 1992. Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages. Biochem. Biophys. Res. Commun. 187:1123-1127.
30. Hong, S., G. Patton, and D. Deykin. 1979. Arachidonic acid levels in cellular lipids determine the amount of prostaglandins synthesized during cell growth in tissue culture. Prostaglandins. 17:53-59.
31. O'Banion, M., H. Sadowski, V. Winn, and D. Young. 1991. A serum-and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J. Biol. Chem. 206:23261-23267.
32. Polgar, P., and L. Taylor. 1980. Alterations in prostaglandin synthesis during senescence of human lung fibroblasts. Mech. Ageing Dev. 12:305-313.
33. Bernd, M., R. Ludwig, E. Zenzmaier, H. Gleispach, and H. Esterbauer. 1984. Characterization of lipoxygenase metabolites of arachidonic acid in cultured human skin fibroblasts. Biochim. Biophys. Acta. 795:151-164.
34. Baud, L., J. Perez, M. Denis, and R. Ardaillou. 1987. Modulation of fibroblast proliferation by sulfidopeptide leukotrienes: effect of indomethacin. J. Immunol. 138:1190-1195.
35. 1, interleukin 1β, and tumor necrosis factor α. J. Biol. Chem. 267:10816-10822.
36. Vane, J. 1994. Towards a better aspirin. Nature (Lond.). 367:215-216.
37. Masferrer, J., B. Zweifel, P. Manning, S. Hauser, K. Leahy, W. Smith, P. Isakson, and K. Seibert. 1994. Selective inhibition of inducible cyclooxygenase-2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. USA. 91:3228-3236.
38. Ham, E., D. Soderman, M. Zanetti, H. Dougherty, E. McCauley, and F. Kuehl, Jr. 1983. Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils. Proc. Natl. Acad. Sci. USA. 80:4349-4353.
39. 2. Free Radical Biol. Med. 3:15-20.
40. 2. J. Immunol. 152:5703-5713.
41. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146:108-113.
42. Goldstein, R., and A. Fine. 1986. Fibrotic reactions in the lung: the activation of the lung fibroblast. Exp. Lung Res. 11:245-261.
43. Borok, Z., A. Gillissen, R. Buhl, R. Hoyt, R. Hubbard, T. Ozaki, S. Rennard, and R. Crystal. 1991. Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E. Am. Rev. Respir. Dis. 144:1080-1084.
44. Conary, J., R. Parker, B. Christman, R. Faulks, G. King, B. Meryick, and K. Brigham. 1994. Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene. J. Clin. Invest. 93:1834-1840.