β-Lactams from ester enolates and N-TMSimines: Enantioselective synthesis of (6R, 7S)-1β-3-dimethyl-3-isocephem

Tetrahedron

Volumn 51, Issue 17, 1995, Pages 5067-5072

  Cainelli, Gianfranco ^a   Panunzio, Mauro ^a   Bandini, Elisa ^b   Martelli, Giorgio ^b   Spunta, Giuseppe ^b   Da Col, Marco ^c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b CNR   (Italy)

^c Biochimica OPOS SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

7 [2 (2 AMINO 4 THIAZOLYL) 2 METHOXYIMINOACETAMIDO] 1BETA,3 DIMETHYL 3 ISOCEPHEM 4 CARBOXYLIC ACID; BETA LACTAM ANTIBIOTIC; CEFACLOR; CEPHEM DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENANTIOMER; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0028923738     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4020(95)98703-K     Document Type: Article

References (49)

1. The Development of Organometallic Methodologies For the Stereospecific Introduction of Cephalosporin Side Chains
2. .beta.-Lactams from ester enolates and silylimines: enantioselective synthesis of the trans-carbapenem antibiotics (+)-PS-5 and (+)-PS-6
3. Metallo-imines: Useful reagents in organic synthesis
4. Total synthesis of nuclear analogues of 7-methylcephalosporin
5. An enantioselective synthesis of 2-isocephem and 2-iso-oxacephem nuclei
6. The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
7. Synthetic studies on β-lactam antibiotics. VII. Mild removal of the benzyl ester protecting group with aluminum trichloride