Structural organization of the spliced immediate-early gene complex that encodes the major acidic nuclear (IE1) and transactivator (IE2) proteins of african green monkey cytomegalovirus

Journal of Biomedical Science

Volumn 2, Issue 2, 1995, Pages 105-130

  Chang, Yung Nien ^a   Jeang, Kuan Teh ^a   Lietman, Tom ^a   Hayward, Gary S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bicistronic genes; Homologous protein domains; Nuclear regulatory proteins

Indexed keywords

REGULATOR PROTEIN;

AFRICAN GREEN MONKEY CYTOMEGALOVIRUS; ARTICLE; CYTOMEGALOVIRUS; DNA SEQUENCE; GENE STRUCTURE; NONHUMAN; PRIORITY JOURNAL;

CERCOPITHECINE HERPESVIRUS 5; CERCOPITHECUS AETHIOPS; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; SUGARCANE MOSAIC VIRUS;

EID: 0028923558     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/BF02253062     Document Type: Article

References (68)

1. The structure of the major immediate-early genes of human cytomegalovirus strain AD169
2. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose
3. An isoform variant of the cytomegalovirus immediate-early autorepressor functions as a transcriptional activator
4. Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids
5. The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulation
6. The palindromic series I repeats in the simian cytomegalovirus major immediate-early promoter behave as both strong basal enhancers and cyclic AMP response elements
7. Identification of a large bent DNA domain and binding sites for serum response factor adjacent to the NFI repeat cluster and enhancer region in the major IE94 promoter from simian cytomegalovirus
8. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169
9. Human cytomegalovirus IE1 transactivates the promoterenhancer via an 18-base-pair repeat element
10. Identification and mapping of dimerization and DNA-binding domains in the C-terminus of the IE2 regulatory protein of human cytomegalovirus
11. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
12. Critical structural elements of the VP16 transcriptional activation domain
13. Anionic regions in nuclear proteins
14. Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteins
15. Neurofilament architecture combines structural principles of intermediate filaments with carboxy-terminal extensions increasing in size between different triplet proteins
16. Enhancement of RNA polymerase II initiation complexes by a novel DNA control domain downstream from the cap site of the cytomegalovirus major immediate-early promoter
17. Immediate-early proteins of human cytomegalovirus strains AD169, Davis and Towne differ in electrophoretic mobility
18. Ribonucleic acid isolated by cesium chloride centrifugation
19. Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells
20. Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoter
21. Global and local deviations from expected frequencies of CpG-dinucleotides in herpes virus DNAs may be diagnostic of differences in the states of their latent genomes
22. Human cytomegalovirus. II: Lack of relatedness of DNA of herpes simplex virus I and II, Epstein Barr virus and nonhuman strains of cytomegalovirus
23. Predominant immediate-early transcripts of human cytomegalovirus AD169
24. Characterization of cytomegalovirus immediate-early genes. I: Nonpermissive rodent cells overproduce the IE94K protein from CMV (Colburn)
25. Abundant constitutive expression of the immediate-early 94K protein from cytomegalovirus (Colburn) in a DNA-transfected mouse cell line
26. A cycloheximide-enhanced protein in cytomegalovirus-infected cells
27. A cytomegalovirus DNA sequence containing tracts of tandemly repeated CA dinucleotides hybridizes to highly repetitive dispersed elements in mammalian cell genomes
28. Organization of the Epstein-Barr virus DNA molecule. III: Location of the P3HR-1 deletion junction and characterization of the NotI repeat units that form part of the template for an abundant 12-O-tetradecanoylphorbol-13-acetate-induced mRNA transcript
29. Multiple tandemly-repeated binding sites for cellular nuclear factor I upstream from the promoter enhancer region for the major immediate-early gene of cytomegalovirus (Colburn)
30. Sequence and structural organization of murine cytomegalovirus immediate-early gene 1
31. Immediate-early genes of murine cytomegalovirus: Location, transcripts, and translation products
32. The 89,000-Mr murine cytomegalovirus immediate-early protein activates gene transcription
33. Structural organization of the DNA molecules from human cytomegalovirus
34. Replicative forms of human cytomegalovirus DNA with joined termini are found in permissively infected human cells but not in non-permissive Balb/c-3T3 mouse cells
35. Constitutive and retinoic acid-inducible expression of cytomegalovirus immediate-early genes in human teratocarcinoma cells
36. Differences in cell type-specific blocks to immediate early gene expression and DNA replication of human, simian and murine cytomegalovirus
37. Expression of the acidic nuclear immediate-early protein (IE1) of human cytomegalovirus in stable cell lines and its preferential association with metaphase chromosomes
38. The 86-kilodalton IE2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter
39. Deletion analysis of GAL4 defines two transcriptional activating segments
40. An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site-dependent repression of transcription and direct binding of IE2 to the major immediate early promoter
41. Transactivation of human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: Mutational analysis of the viral proteins
42. Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus-6
43. Sequencing end-labelled DNA with base-specific chemical cleavage
44. Analysis of single and double stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange
45. Structural organization, expression and functional characterization of the murine cytomegalovirus immediate-early gene 3
46. Identification of the viral gene product and target sequence responsible for herpesvirus induction of HIV LTR
47. A catalogue of splice junction sequences
48. Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones
49. Expression of recombinant genes containing herpes simplex virus delayed-early and immediate-early regulatory regions and trans activation by herpesvirus infection
50. An efficient mRNA-dependent translation system from reticulocyte lysates
51. The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap site
52. The functionally active IE2 immediate-early regulatory protein of human cytomegalovirus is an 80-kilodalton polypeptide that contains two distinct activator domains and a duplicated nuclear localization signal
53. Trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus
54. An inducible promoter mediates abundant expression from the immediate-early 2 gene region of human cytomegalovirus at late times after infection
55. Characterization of the major locus of immediate-early genes of rat cytomegalovirus
56. DNA sequencing with chain-terminating inhibitors
57. A simple method for DNA restriction site mapping
58. Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region
59. Promoter-specific trans-activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains
60. Structural analysis of the major immediate-early gene of human cytomegalovirus
61. Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1
62. Sequence of protein synthesis in cells infected by human cytomegalovirus: Early and late virus-induced polypeptides
63. Organization and expression of the immediate-early genes of human cytomegalovirus
64. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose
65. 3′-End labelling of DNA with [32P]cordycepin-5′ triphosphate
66. Temporal patterns of human cytomegalovirus transcription: Mapping the viral RNAs synthesized at immediate early, early and late times after infection
67. Transcription of the immediate early genes of human cytomegalovirus virus strain AD169