Detection of aneuploidy-inducing carcinogens in the Syrian hamster embryo (SHE) cell transformation assay

Mutation Research/Genetic Toxicology

Volumn 343, Issue 1, 1995, Pages 7-24

  Gibson, David P ^a   Aardema, Marilyn J ^a   Kerckaert, Gary A ^a   Carr, Gregory J ^a   Brauninger, Roger M ^b   LeBoeuf, Robert A ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b UK   (United States)

Author keywords

Aneuploidy; Cell transformation; Nongenotoxic carcinogen detection

Indexed keywords

ASBESTOS; BENOMYL; CADMIUM CHLORIDE; CARCINOGEN; CHLORAL HYDRATE; DEMECOLCINE; DIAZEPAM; DIETHYLSTILBESTROL; ECONAZOLE; GRISEOFULVIN; PYRIMETHAMINE; TIABENDAZOLE;

ANEUPLOIDY; ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; NONHUMAN; PRIORITY JOURNAL; SCREENING TEST;

ANEUPLOIDY; ANIMAL; ASBESTOS; BENOMYL; CADMIUM; CADMIUM CHLORIDE; CARCINOGENICITY TESTS; CARCINOGENS; CELLS, CULTURED; CHLORAL HYDRATE; CHLORIDES; COMPARATIVE STUDY; DEMECOLCINE; DIAZEPAM; DIETHYLSTILBESTROL; ECONAZOLE; EMBRYO; EVALUATION STUDIES; GRISEOFULVIN; HAMSTERS; MESOCRICETUS; PYRIMETHAMINE; THIABENDAZOLE;

EID: 0028922325     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1218(95)90058-6     Document Type: Article

References (94)

1. Mouse micronucleus tests with known and suspect spindle poisons: results from two laboratories
2. Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEEC collaborative study
3. The morphological transformation of Syrian hamster embryo cells by chemicals reportedly nonmutagenic to Salmonella typhimurium
4. Evidence for the progressive nature of neoplastic transformation in vitro
5. Diethylstilbestrol induces neoplastic transformation of cells in culture without measurable somatic mutation at two loci
6. Role of chemically induced mutagenic events in neoplastic transformation of Syrian hamster embryo cells
7. Role of aneuploidy in early and late stages of neoplastic progression in Syrian hamster embryo cells in culture
8. Cellular and molecular mechanisms of multistep neoplastic transformation of cells in culture
9. Multiple mechanisms for the carcinogenic effects of asbestos and other mineral fibers
10. Membrane-damaging agents causing mitotic non-disjunction in Aspergillus nidulans
11. In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons
12. Recessive mutant genes predisposing to human cancer
13. Cytogenetic and morphological changes in oogenesis and embryogenesis of albino rats induced by chloridin and 2,4,5-trichlorophenoxyacetic acid in the preovulation phase of meiosis
14. Induction of aneuploidy in mouse bone marrow cells with diethylstilbestrol diphosphate
15. Antimitotic activity of methyl benzimidazole-2-yl carbamate (MBC) in Aspergillius nidulans
16. Differential binding of methyl benzimidazole-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans
17. Griseofulvin
18. Carcinogenic, teratogenic and mutagenic effects of cadmium
19. Carcinogenesis bioassay of prazepam (Verstran) in rats and mice
20. Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde and dichloroacetic acid in the male B6C3F1 mouse
21. Scanning electron microscopy of Candida albicans after in vitro treatment with miconazole
22. Detection of Aneugenic Chemicals-CEEC project
23. Transformation of hamster cells in vitro by polycyclic hydrocarbons without cytotoxicity
24. Quantitative studies of in-vitro morphological transformation of Syrian hamster cells by inorganic metal salts
25. Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver
26. Comparative neoplastic transformation responses of Balb/3T3 cells, Syrian hamster embryo cell and rauscher murine leukemia virus-infected Fischer 344 rat embryo cells to chemical carcinogens
27. A genetic model for colorectal tumorigenesis
28. Chronic oral toxicity and carcinogenicity study of thiabendazole in rats
29. Assessment of the in vivo aneuploidy/micronucleus assay in mouse bone marrow cells with 16 chemicals
30. Effects of diethylstilboestrol-dipropionate on SCEs, micronuclei, cytotoxicity, aneuploidy and cell proliferation in maternal and foetal mouse cells treated in vivo
31. Role of phagocytosis in Syrian hamster cell transformation and cytogenetic effects induced by asbestos and short and long glass fibers
32. Dependence of asbestos- and mineral dust-induced transformation of mammalian cell in culture on fiber dimension
33. Induction of asbestos fibers of anaphase abnormalities: mechanism for aneuploidy induction and possibly carcinogenesis
34. The impact of aneuploidy upon public health: mortality and morbidity associated with human chromosome abnormalities
35. Aneuploidy induction by mitotic arrestants, Effects of diazepam on diploid Chinese hamster cells
36. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
37. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
38. Alterations in cellular differentiation cytoskeleton and growth characteristics during Syrian hamster embryo cell multistep in vitro transformation
39. Growth factor responsiveness and alterations in growth factor homeostasis in Syrian hamster embryo cells during in vitro transformation
40. Diethylstilbestrol-diphosphonate induces chromosomal aberrations but not sister chromatid exchanges in murine bone marrow cells in vitro and in vivo
41. Teratogenic effects of benomyl in the Wistar rat and CD-1 mouse with emphasis on the route of administration
42. Mechanistic studies on chloral toxicity: relationship to trichloroethylene carcinogenesis
43. Induction of selective DNA amplification and morphological cell transformation in Syrian hamster embryo cells
44. Mode of action of benzimidazoles
45. The effects of benzodiazepines upon the fidelity of mitotic cell division in cultured Chinese hamster cells
46. In vivo studies on chemically induced aneuploidy in mouse somatic and germ cells
47. The induction of transformed like morphology and enhanced growth in Syrian hamster embryo cells grown at acidic pH
48. Enhanced morphological transformation of early passage Syrian hamster embryo cells cultured in medium with a reduced bicarbonate concentration and pH
49. An interlaboratory comparison of enhanced morphological transformation of Syrian hamster embryo cells cultured under conditions of reduced bicarbonate concentration and pH
50. Multistage neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70
51. Chemical probes and possible targets for the induction of aneuploidy
52. Mammalian in vivo assays for aneuploidy in female germ cells
53. Analysis of mouse metaphase II oocytes as an assay for chemically induced aneuploidy
54. Cytogenetic analysis of mouse oocytes and one cell zygotes as a potential assay for heritable germ cell aneuploidy
55. Benomyl-induced aneuploidy in mouse oocytes
56. Investigation of aneuploidy induction in mouse oocytes following exposure to vinblastine-sulfate, pyrimethamine, diethylstilbestrol diphosphate, or chloral hydrate
57. Griseofulvin-induced aneuploidy and meiotic delay in mouse oocytes: effect of dose and harvest time
58. Griseofulvin-induced aneuploidy and meiotic delay in female germ cells. II. Cytogenetic analysis of one-cell zygotes
59. Comparison of the aneugenic activity of diazepam in mouse oocytes and other mammalian cells
60. Morphological and neoplastic transformation of Syrian hamster embryo fibroblasts by Diethylstilbestrol and its analogs
61. Morphological transformation of Syrian hamster embryo cells induced by mineral fibers and the alleged enhancement of benzo[a]pyrene
62. Aneuploidy induction in mouse spermatocytes
63. Mutagenic bioassay of certain pharmacological drugs, I. Thiabendazole (TBZ)
64. An overview of the results of testing of known or suspected aneugens using mammalian cells in vitro
65. Management status report 10-8-93
66. Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells
67. Double nondisjunction during karyotypic progression of chemically induced Syrian hamster cell lines
68. Correlation of asbestos-induced cytogenetic effects with cell transformation of Syrian hamster embryo cells in culture
69. Chemically induced aneuploidy in mammalian cells: Mechanisms and biological significance in cancer
70. An early, nonrandom karyotypic change in immortal Syrian hamster cell lines transformed by asbestos: trisomy of chromosome 11
71. Transformation of Syrian hamster embryo cells by diverse chemicals and correlation with their reported carcinogenic and mutagenic activities
72. Metal salts as promoters of in vitro morphological transformation of hamster embryo cells initiated by benzo(a)pyrene
73. Evidence that griseofulvin binds to a microtubule associated protein
74. Further studies on incomplete carcinogenesistriethylene melamine (TEM) 12-benzanthracene and β-propiolactone as initiator of skin tumor formation in the mouse
75. Non-disjunction induced in mouse spermatogenesis by chloral hydrate, a metabolite of trichloroethyle
76. Tests with Syrian hamster embryo (SHE) cell transformation assay
77. Dislocation of chromatin elements in prophase induced by diethylstilbestrol: a novel mechanism by which micronuclei can arise
78. Induction of morphological transformation and unscheduled DNA synthesis in Syrian hamster embryo fibroblasts by hexachlorobutadiene and its putative metabolite pentachlorobutenoic acid
79. Drug Res.
80. Teratogenic and cytogenetic effects of some plant-derived antitumor agents (vincristine, colchicine, maytansine, VP-16-213 and VM-26) in mice
81. Preliminary studies of the in-vitro cellular effects of asbestos and fine glass dusts
82. Lung tumors in strain A mice as a bioassay for carcinogenicity of environmental chemicals
83. Cytotoxic effects of various pesticides in vivo and in vitro
84. Griseofulvin-induced aneuploidy and meiotic delay in female germ cells I Cytogenetic analysis of metaphase II oocytes
85. An interlaboratory comparison of transformation in Syrian hamster embryo cells with model and coded chemicals
86. Decreased numbers of spindle and cytoplasmic microtubules in hamster embryo cells treated with carcinogen, diethylstibestrol
87. Aneuploidy induction and cell transformation by diethylstilbestrol: a possible chromosomal mechanism in carcinogenesis
88. Colcemid-induced neoplastic transformation and aneuploidy in Syrian hamster embryo cells
89. Vincristine sulfate-induced cell transformation, mitotic inhibition and aneuploidy in cultured Syrian hamster embryo cells
90. 17-estradiol-induced cell transformation and aneuploidy of Syrian hamster embryo cells in culture
91. The cytochrome P-450 dependent C17,20-lyase in subcellular fractions of the rat testis: differences in sensitivity to ketaconazole and intraconazole
92. Studies of the interaction of chemicals with microtubule assembly in vitro which can be used as an assay for the detection of cytotoxic chemicals and possible inducers of aneuploidy
93. A cytogenetic approach to evaluate in vivo somatic aneuploidy. Effects of diethylstilbestrol on mouse bone marrow cells