Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction

Journal of Clinical Investigation

Volumn 95, Issue 3, 1995, Pages 1092-1100

  Neubauer, Stefan ^a   Horn, Michael ^a   Naumann, Anne ^a   Tian, Rong ^a   Hu, Kai ^a   Laser, Martin ^a   Friedrich, Jan ^c   Gaudron, Peter ^a   Schnackerz, Klaus ^b   Ingwall, Joanne S ^c   Ertl, Georg ^a  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE; CREATINE KINASE; CREATINE PHOSPHATE; OXYGEN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; ENERGY METABOLISM; HEART HEMODYNAMICS; HEART INFARCTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE OXYGEN CONSUMPTION; HYPOXEMIA; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION;

EID: 0028918277     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117756     Document Type: Article

References (53)

1. Pfeffer, M. A., J. M. Pfeffer, M. C. Fishbein, P. J. Fletcher, J. Spadaro, R. A. Kloner, and E. Braunwald. 1979. Myocardial infarct size and ventricular function in rats. Circ. Res. 44:503-512.
2. Pfeffer, J. M., M. A. Pfeffer, P. J. Fletcher, and E. Braunwald. 1991. Progressive ventricular remodeling in rat with myocardial infarction. Am. J. Physiol. 260:H1406-H1414.
3. 2+-exchanger early after infarction: normalization in the chronic healing phase despite persistent up-regulation of ANF-expression. Circulation. 88:I-246a. (Abstr.)
4. Michel, J. B., J. L. Lattion, M. L. Cerol, M. Philippe, J. P. Camilleri, and P. Corvol. 1988. Hormonal and cardiac effects of converting enzyme inhibition in rat myocardial infarction. Circ. Res. 62:641-650.
5. Ingwall, J. S. 1993. Is cardiac failure a consequence of decreased energy reserve? Circulation. 87(Suppl. VII):VII-58-VII-62.
6. Ingwall, J. S., D. E. Atkinson, K. Clarke, and J. K. Fetters. 1990. Energetic correlates of cardiac failure: changes in the creatine kinase system in the failing myocardium. Eur. Heart J. II(Suppl. C):108-115.
7. Zhang, J., M. Yoshiyama, K. Hendrich, H. Liu, H. Merkle, M. Garwood, A. H. L. From, R. J. Bache, and K. Ugurbil. 1991. Myocardial bioenergetics in the hypertrophied left ventricle studied by transmural P-31 NMR spectroscopy. Proc. 10th Annu. Meet. SMRM. 2:911a. (Abstr.)
8. 31P nuclear magnetic resonance spectroscopy: improvement after acute verapamil therapy. Circ. Res. 59:597-604.
9. Wexler, L. F., B. H. Lorell, S. Momomura, E. O. Weinberg, J. S. Ingwall, and C. S. Apstein. 1988. Enhanced sensitivity to hypoxia-induced diastolic dysfunction in pressure-overload left ventricular hypertrophy in the rat: role of high-energy phosphate depletion. Circ. Res. 62:766-775.
10. Shimamoto, N., N. Goto, M. Tanabe, T. Imamoto, S. Fujiwara, and M. Hirata. 1982. Myocardial energy metabolism in the hypertrophied hearts of spontaneously hypertensive rats. Basic Res. Cardiol. 77:359-371.
11. Gaudron, P., M. Blumrich, and G. Ertl. 1993. Aggravation of left ventricular dilatation and reduction of survival by a calcium channel blocker in rats with chronic myocardial infarction. Am. Heart J. 125:1226-1233.
12. Neubauer, S., G. Ertl, U. Haas, F. Pulzer, and K. Kochsiek. 1990. Effects of Endothelin-1 in the isolated perfused rat heart. J. Cardiovasc. Pharmacol. 16:1-8.
13. eq of the creatine kinase reaction and other phosphate hydrolyses and phosphate transfer reactions. J. Biol. Chem. 254:6528-6537.
14. 31P-NMR magnetization transfer study of the isolated ferret heart. Circ. Res. 63:1-15.
15. Forsen, S., and R. A. Hoffman. 1963. Study of moderately rapid chemical exchange reactions by means of nuclear magnetic double resonance. J. Chem. Phys. 39:2892-2901.
16. 31P-NMR magnetization transfer study. J. Biol. Chem. 260:3512-3517.
17. Mc Auliffe, J. J., S. B. Perry, E. E. Brooks, and J. S. Ingwall. 1993. Kinetics of the creatine kinase reaction in neonatal rabbit heart: an empirical analysis of the rate equation. Biochemistry. 30:2585-2593.
18. 31P-NMR studies of isolated rat heart. J. Mol. Cell. Cardiol. 21:1163-1178.
19. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
20. Rosalki, S. B. 1967. An improved procedure for serum creatine phosphokinase determination. J. Lab. Clin. Med. 69:696-705.
21. Hall, N., and M. DeLuca. 1976. Electrophoretic separation and quantitation of creatine kinase isozymes. Anal. Biochem. 76:561-567.
22. Basson, C. T., A. M. Grace, and R. Roberts. 1985. Enzyme kinetics of a highly purified mitochondrial creatine kinase in comparison with cytosolic forms. Mol. Cell. Biochem. 67:151-159.
23. Bernstein, L. H., and J. Everse. 1975. Determination of the isoenzyme levels of lactate dehydrogenase. Methods Enzymol. 41:47-52.
24. Oblinger, M. M., L. G. Foe, D. Kwiatkowska, and R. G. Kemp. 1988. Phosphofructokinase in the rat nervous system: regional differences in activity and characteristics of axonial transport. J. Neurosci. Res. 21:25-34.
25. GAPdH: Methods of Enzymatic Analysis. 1974. Edited by Hans Ulrich Bergmeyer, in collaboration with Karlfried Gawehn. Second English Edition. Volume 1. 466-467.
26. Srere, P. A., H. Brazil, and L. Gowen. 1963. The citrate condensing enzyme of pigeon breast muscle and moth flight muscle. Acta Chem. Scand. 17(Suppl. 1):S129-S134.
27. Kammermeier, H. 1973. Microassay of free and total creatine from tissue extracts by combination of chromatographic and fluorometric methods. Anal. Biochem. 56:341-345.
28. Neely, J. R., H. Liebermeister, E. J. Battersby, and H. E. Morgan. 1967. Effect of pressure development on oxygen consumption by isolated rat heart. Am. J. Physiol. 212:804-815.
29. Sanbe, A., K. Tanonaka, Y. Hanaoka, T. Katoh, and S. Takeo. 1993. Regional energy metabolism of failing hearts following myocardial infarction. J. Mol. Cell. Cardiol. 25:995-1013.
30. Zar, J. H. 1974. Biostatistical Analysis. Prentice Hall, Englewood Cliffs, NJ. 130-181.
31. Winer, B. J. 1971. Statistical Principles in Experimental Design. Chapter 7. McGraw-Hill, New York.
32. Anversa, P., C. Beghi, Y. Kikkawa, and G. Olivetti. 1986. Myocardial infarction in rats: infarct size, myocyte hypertrophy, and capillary growth. Circ. Res. 58:26-37.
33. Zimmer, H. G., A. M. Gerdes, S. Lortet, and G. Mall. 1990. Changes in heart function and cardiac cell size with chronic myocardial infarction. J. Mol. Cell. Cardiol. 22:1231-1243.
34. Vleeming, W., H. H. van Rooij, J. Wemer, and A. J. Porsius. 1991. Cardiovascular responses to the stereoisomers of dobutamine in isolated rat hearts 48 hours after acute myocardial infarction. J. Cardiovasc. Pharmacol. 17:634-640.
35. Litwin, S. E., and J. P. Morgan. 1992. Captopril enhances intracellular calcium handling and β-adrenergic responsiveness of myocardium from rats with postinfarction failure. Circ. Res. 71:797-807.
36. Wolff, M. R., P. P. de Tombe, Y. Harasawa, D. Burkhoff, S. Bier, W. C. Hunter, G. Gerstenblith, and D. A. Kass. 1992. Alterations in left ventricular mechanics, energetics and contractile reserve in experimental heart failure. Circ. Res. 70:516-529.
37. Nozawa, T., C. P. Cheng, T. Noda, and W. C. Little. 1994. Relation between left ventricular oxygen consumption and pressure-volume area in conscious dogs. Circulation. 89:810-817.
38. Takaoka, H., M. Takeuchi, M. Odake, Y. Hayashi, K. Hata, M. Mori, and M. Yokoyama. 1993. Comparison of hemodynamic determinants for myocardial oxygen consumption under different contractile states in human ventricle. Circulation. 87:59-69.
39. De Tombe, P. P., M. R. Wolff, D. A. Kass, W. C. Hunter, I. Reis, and J. S. Ingwall. 1991. Creatine kinase isoenzyme expression is altered in experimental canine dilated cardiomyopathy without hypertrophy. Circulation. 84:II-280a. (Abstr.)
40. Ingwall, J. S., M. F. Kramer, M. A. Fifer, B. H. Lorell, R. Shemin, W. Grossman, and P. D. Allen. 1985. The creatine kinase system in normal and diseased myocardium. N. Engl. J. Med. 313:1050-1054.
41. Nascimben, L., P. Pauletto, A. C. Pessina, I. Reis, and J. S. Ingwall. 1991. Decreased energy reserve may cause pump failure in human dilated cardiomyopathy. Circulation. 84:II-563a. (Abstr.)
42. Bester, A. J., E. Bajusz, and A. Lochner. 1972. Effect of ischemia and infarction on the metabolism and function of the isolated, perfused rat heart. Cardiovasc. Res. 6:284-294.
43. Fellenius, E., C. A. Hansen, O. Mjos, and J. R. Neely. 1985. Chronic infarction decreases maximum cardiac work and sensitivity of the heart to extracellular calcium. Am. J. Physiol. 249:H80-H87.
44. Vatner, D. E., and J. S. Ingwall. 1984. Effects of moderate pressure overload cardiac hypertrophy on the distribution of creatine kinase isozymes. Proc. Soc. Exp. Biol. Med. 175:5-9.
45. Schultheiss, H. P., G. Ullrich, M. Schindler, K. Schulze, and B. E. Strauer. 1990. The effect of ACE inhibition on myocardial energy metabolism. Eur. Heart J. 11(Suppl. B):116-122.
46. Meerson, F. Z., and M. P. Javich. 1982. Isoenzyme pattern and activity of myocardial creatine phosphokinase under heart adaptation to prolonged overload. Basic Res. Cardiol. 77:349-358.
47. Ingwall, J. S., and E. T. Fossel. 1983. Changes in the creatine kinase system in the hypertrophied myocardium of the dog and rat. In Perspectives in Cardiovascular Research. Vol. 7. Myocardial Hypertrophy and Failure. N. R. Alpert, editor. Raven Press, New York. 601-617.
48. Sharkey, S. W., M. M. Murakami, S. A. Smith, and F. S. Apple. 1991. Canine myocardial creatine kinase isoenzymes after chronic coronary artery occlusion. Circulation. 84:333-340.
49. Pfeffer, J. M., M. A. Pfeffer, P. J. Fletcher, and E. Braunwald. 1991. Progressive ventricular remodeling in rat with myocardial infarction. Am. J. Physiol. 260:H1406-H1414.
50. Hamman, B. L., J. A. Bittl, W. E. Jacobus, and J. S. Ingwall. 1986. Inhibition of creatine kinase decreases the contractile reserve of the isolated rat heart. Proc. 5th Annu. Meet. SMRM. WIP:133.
51. van Deursen, J., A. Heerschap, F. Oerlemans, W. Ruitenbeek, P. Jap, H. ter Laak, and B. Wieringa. 1993. Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity. Cell. 74:621-631.
52. 31P spectroscopic imaging of regional high-energy phosphate metabolism in chronic myocardial infarction. Proc. 12th Annu. Meet. SMRM. I-357.
53. 31P spectroscopic imaging of remodeled myocardium of the infarcted heart. Circulation. 88(Suppl.):I-379a. (Abstr.)