Two conformational states of amyloid β-peptide: implications for the pathogenesis of Alzheimer's disease

Neuroscience Letters

Volumn 186, Issue 2-3, 1995, Pages 115-118

  Soto, Claudio ^a   Frangione, Blas ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Amyloidogenic conformation; Soluble amyloid

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ARTICLE; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ALGORITHMS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CIRCULAR DICHROISM; HUMAN; NEUROFIBRILLARY TANGLES; PROTEIN CONFORMATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028917968     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(95)11299-C     Document Type: Article

References (28)

1. Solution conformations and aggregational properties of synthetic amyloid β-peptides in Alzheimer's disease
2. Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptides and analogs
3. Rapid induction of Alzheimer Aβ amyloid formation by zinc
4. Gene-dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families
5. Amyloid deposits and amyloidosis. The β-fibrillogenesis
6. Computed circular dichroism spectra for the evaluation of protein conformation
7. The carboxy terminus of the β-amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease
8. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
9. Amyloid β-peptide is produced by cultured cells during normal metabolism
10. Aggregation and secondary of synthetic βA4 peptides of Alzheimer's disease
11. Amyloid-associated proteins a1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments
12. Kinetic analysis of amyloid fibril polymerization in vitro
13. Persistence of the α-helix stop signal in the S-peptide in trifluoethanol solutions
14. Conversion of α-helices into β-sheets features in the formation of the scrapie prion proteins
15. Convex contraint analysis: a natural deconvolution of circular dichroism curves of proteins
16. Analysis of the circular dichroism spectrum of proteins using the conex constraint algorithm: a practical guide
17. Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state
18. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
19. Production of the Alzheimer amyloid β-protein by normal proteolytic processing
20. Structure determinations of extracellular fragments of amyloid proteins involved in Alzheimer's disease and Dutch-type hereditary cerebral haemorrhage with amyloidosis
21. Structural determinants of the Alzheimer's amyloid β-peptide
22. Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing
23. Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid
24. Alzheimer's disease and soluble Aβ
25. Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro
26. NMR studies of amyloid β-peptides: proton assignments, secondary structure and mechanism of an α-helix to β-sheet conversion for an homologous 28-residue, N-terminal fragment