Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide

Chirality

Volumn 7, Issue 1, 1995, Pages 44-52

  Eriksson, Tommy ^a   Bjöurkman, Sven ^a   Roth, Bodil ^a   Fyge, Årsa ^a   Höuglund, Peter ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

chiral inversion; high performance liquid chromatography; in vitro kinetics; stereoselective pharmacokinetics; stereospecific analysis; thalidomide enantiomers

Indexed keywords

THALIDOMIDE;

ADULT; ARTICLE; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG DETERMINATION; DRUG TRANSFORMATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RACEMIC MIXTURE; STEREOCHEMISTRY;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOUBLE-BLIND METHOD; HALF-LIFE; HUMAN; INTESTINAL ABSORPTION; MALE; MOLECULAR CONFORMATION; STEREOISOMERISM; THALIDOMIDE;

EID: 0028916174     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.530070109     Document Type: Article

References (25)

1. Thalidomide and congeners as anti‐inflammatory agents
2. Thalidomide in human immunodeficiency virus (HIV) patients
3. Thalidomide in the treatment of lepra reactions
4. Thalidomide use in dermatology
5. Thalidomide for the treatment of chronic graft‐versus‐host disease
6. Thalidomide—the need for a new clinical evaluation of an old drug
7. Thalidomide revisited
8. Thalidomide given to women in Brazil
9. Thalidomide neuropathy incidence and clinicoelectrophysiologic findings in 42 patients
10. Toxicity and teratogenicity of optical isomers of thalidomide
11. Chromatographische Racemattrennung von Thalidomid und teratogene Wirkung der Enantiomere
12. Effect of thalidomide on the graft versus host reaction
13. Improvements in solubility and stability of thalidomide upon complexation with hydroxypropyl‐β‐cyclodextrin
14. The so‐called “interconversion” of stereoisomeric drugs: an attempt at clarification
15. Plasma pharmacokinetics and urinary excretion of thalidomide after oral dosing in healthy male volunteers
16. Disposition of thalidomide in rabbits and rats
17. The metabolism of thalidomide: the fate of thalidomide and some of its hydrolysis products in various species
18. Stereoselectivity of the in vitro metabolism of thalidomide
19. Investigations on the in vitro racemization of thalidomide by HPLC
20. Racemattrennung des Thalidomids und anderer Glutarimid‐Derivate
21. Direct HPLC separation of thalidomide enantiomers using cellulose tris‐4‐methylphenyl benzoate chiral stationary phase
22. Determination of thalidomide in plasma and blood by high‐performance liquid chromatography: avoiding hydrolytic degradation
23. Enigmatic properties of (±)‐thalidomide; an example of a stable racemic compound
24. The determination of essential clearance, volume, and residence time parameters of recirculating metabolic systems: the reversible metabolism of methylprednisolone and methylprednisone in rabbits
25. Pharmacokinetics of factor IX in patients with haemophilia B. Methodological aspects and physiological interpretation