Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABAA Receptors

Journal of Neuroendocrinology

Volumn 7, Issue 3, 1995, Pages 171-177

  Bitran, Daniel ^a   Shiekh, Michael ^a   McLeod, Michael ^a  

^a Center for Interdisciplinary Studies   (United States)

Author keywords

3 hydroxy 5 pregnan 20 one; 4 MA; 5 reductase; defensive burying; elevated plus maze; GABAA receptor; RU 38486

Indexed keywords

17BETA (N,N DIETHYLCARBAMOYL) 4 METHYL 4 AZA 5ALPHA ANDROSTAN 3 ONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE DERIVATIVE; CHLORIDE ION; MIFEPRISTONE; PICROTOXIN; PROGESTERONE; STEROID RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CHLORIDE TRANSPORT; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; FEMALE; MAZE TEST; NEUROCHEMISTRY; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; REDUCTION; TRANQUILIZING ACTIVITY;

ANALYSIS OF VARIANCE; ANIMAL; ANTI-ANXIETY AGENTS; AZASTEROIDS; BRAIN; ESTRUS; FEMALE; MIFEPRISTONE; OVARIECTOMY; OVARY; OXIDOREDUCTASES; PICROTOXIN; PREGNANOLONE; PROGESTERONE; RATS; RECEPTORS, GABA-A; STANOLONE; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028916048     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.1995.tb00744.x     Document Type: Article

References (45)

1. The premenstrual syndrome‐new views
2. A placebo‐controlled study of effects of oral progesterone on performance and mood
3. Progesterone and premenstrual syndrome: a double‐blind crossover study
4. Ethologically‐based animal models of anxiety disorders
5. Effect of ovarian hormones on conflict behavior
6. Sexual behavior 11
7. Changes in burying behavior during the estrous cycle: effect of estrogen and progesterone
8. Anxiolytic effect of proges‐terone is associated with increases in cortical allopregnanolone and GABA, receptor function
9. Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: a possible rat model of PMS anxiety
10. Anxiolytic effects of benzodiazepines and 5‐HTIA agonists, animal models
11. Steroid effects on neuronal activity: when is the genomen involved
12. Neurosteroids: endogenous bimodal modulators of the GABA, receptor. Mechanism of action and physiological significance
13. Anxiolytic effects of 3a‐hydroxy‐5a[∼]‐pregnan‐20‐one: Endogenous metabolites of progester‐one that are active at the GABA, receptor
14. Anxiolytic activity of the progesterone metabolite 5a‐pregnan‐3cc‐ol‐2O‐one
15. Anticonvulsant profile of the progesterone metabolite 5a‐pregnane‐3a‐ol‐20‐one
16. The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex
17. Analgesic effects of the progesterone metabolite, 3cc‐hydroxy‐5a‐pregnan‐20‐one, and possible modes of action
18. Effects of progesterone on 3sS‐t‐butylphosphorothionate binding in some forebrain areas of the female rat and its correlation to aggressive behavior
19. Progesterone inhibition of aggressive behaviors in hamsters
20. In vivo studies identify 5a‐pregnan‐3a‐ol‐20‐one as an active anesthetic agent
21. Evidence that 5a‐pregnan‐3a‐ol‐20‐one is the metabolite responsible for progesterone anesthesia
22. The anesthetic potency of 3a‐hydroxy‐5a‐pregnan‐20‐one and 3a‐hydroxy‐5p‐pregnan‐20‐one determined with an intravenous EEG‐threshold method in male rats
23. Neuropharmacological profile of an anxiolytic
24. Antagonism offemale sexual behavior with intracerebral implants of antiprogestin RU 38486: correlation with binding to neural progestin receptors
25. Response of rat ventral prostate to a new and novel Sa‐reductase inhibitor
26. Progesterone recep‐tor‐mediated eflects of neuroactive steroids
27. Neuroactive steroids
28. Neurosteroids: 3r‐hydroxy‐5a‐pregnan‐20‐one and its pre‐cursors in the brain, plasma, and steroidogenic glands of male and female rats
29. Peripheral‐type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function
30. Characterization of steroid interactions with the GABA receptor‐gated chloride ion channel: Evidence for multiple steroid recognition sites
31. Neurosteroids act on recombinant human GABA, receptors
32. GABA, receptor level changes in female hamster forebrain following in vivo estrogen progesterone and benzodiazepine treatment: a quantitative autoradiography analysis
33. Regulation of high‐affinity GABA, receptors in the dorsal hippocampus by estradiol and progesterone
34. Steroid hormones and receptors of the GABA, supramolecular complex. I. Benzodiazepine receptor level changes in some extrahypothalamic brain areas of the female rat following sex steroid treatment
35. Regulation of central and peripheral benzodiazepine receptors in progesterone‐treated rats
36. Steroid hormones and receptors of the GABA, receptor supramolecular complex. 11. Progesterone and estrogen inhibitory effects on the chloride ion channel receptor in different forebrain areas of the female rat
37. The actions of diazepam and serotonergic anxiolytics vary according to the gender and the estrous cycle phase
38. Ovarian endocrine status modulates the anxiolytic potency of diazepam and the efficacy of GABA/benzodiazepine receptor‐mediated chloride ion transport
39. The influence of estrus cycle on neuros‐teroid potency at the 7‐aminobutyric acid, receptor complex
40. Functional changes in GABA, receptor stimulation during the estrous cycle of the rat
41. Validation of open:closed arm entries in an elevated plus‐maze as a measure of anxiety in the rat
42. Conditioned defensive bury‐ing: a new paradigm for the study of anxiolytic agents
43. y‐Aminobutyric acid (GABA)‐and barbiturate‐mediated CI‐ uptake in rat brain synaptoneu‐rosomes: evidence for rapid desensitization. of the GABA receptor‐coupled chloride ion channel
44. Radioimmunoassay of 3a‐hydroxy‐5a‐pregnan‐20‐one in rat and human plasma
45. Protein determinations in membrane and lipoprotein samples: manual and automated procedures