The hydrophobic barrier properties of gastrointestinal mucus

Annual Review of Physiology

Volumn 57, Issue , 1995, Pages 565-583

  Lichtenberger, L M ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Helicobacter pylori; peptic ulcer; phospholipid; prostaglandins; stomach; surfactants

Indexed keywords

ACETYLSALICYLIC ACID; ALUMINUM; ANTACID AGENT; BISMUTH; GOLD; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHOLIPID; PROTECTIVE AGENT; SALICYLIC ACID; SUCRALFATE; SURFACTANT; TEPRENONE; TERPRENONE; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; GASTROINTESTINAL MUCOSA; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; STOMACH ULCER;

EID: 0028915433     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.ph.57.030195.003025     Document Type: Review

References (103)

1. Adamson AW. 1967. The Physical Chemistry of Surfaces, pp. 476-78. New York: Intersciences. 2nd ed.
2. Allen A. 1989. Gastrointestinal mucus. In The Gastrointestinal System, ed. SG Schultz, JG Forte, BB Rauner, 3:309-82. Bethesda: Am. Physiol. Soc.
3. Allen A, Flemström G, Garner A, Kivilaakso E. 1993. Gastroduodenal mucosal protection. Physiol. Rev. 73:823-57
4. Aono M, Moriga M, Mizata K, Uchino H. 1986. Effect of terprenone on the content of phospholipids in gastric secretions in man. Gastroenterol. Jpn. 21: 454-58
5. Berstad K, Berstad A. 1993. Helicobacter pylori infection in peptic ulcer disease. Scand. J. Gastroenterol. 28: 561-67
6. Bilski J, Sarosiek J, Murty VLN, Aono M, Moriga M, et al. 1987. Enhancement of the lipid content and physical properties of gastric mucus by geranyl-geranylacetone. Biochem. Pharmacol. 36:4059-65
7. Butler BD, Lichtenberger LM, Hills BA. 1983. Distribution of surfactants in the canine GI tract and their ability to lubricate. Am. J. Physiol. 7:G645-51
8. Davenport HW. 1964. Gastric mucosal injury by fatty and acetyl salicylic acids. Gastroenterology 46:245-53
9. Davenport HW. 1967. Ethanol damage to the oxyntic glandular mucosa. Proc. Soc. Exp. Biol. Med. 126:657-62
10. Davenport HW. 1970. Effect of lysolecithin, digitonin, and phospholipase A upon the dog's gastric mucosal barrier. Gastroenterology 59: 505-9
11. Davenport HW. 1972. Why the stomach does not digest itself. Sci. Am. 226:86-93
12. Davenport HW, Warner HA, Code CF. 1964. Functional significance of gastric mucosal barrier to sodium. Gastroenterology 47:142-52
13. DeSchryver-Kecskemet K, Eliakim R, Carroll S, Stenson WF, Moxley MA, Alpers DH. 1989. Intestinal surfactant-like material. J. Clin. Invest. 84:1355-61
14. 2 on glycoprotein and lipid synthesis of gastric epithelial cells grown in primary culture. In Vitro Cell Dev. Biol. 27A:39-46
15. Dial EJ, Lichtenberger LM. 1984. A role for milk phospholipids in protection against gastric acid: studies in adult and suckling rats. Gastroenterology 87:379-85
16. Dial EJ, Lichtenberger LM. 1986. Development of gastric mucosal protection against acid in the rat: role of cortico-steroids and prostaglandins Gastroenterology 91:318-25
17. Dial EJ, Lichtenberger LM. 1987. Milk protection against experimental ulcerogenesis in rats. Dig. Dis. Sci. 32: 1145-50
18. 2. Gastroenterology 94:57-67
19. Dial EJ, Lichtenberger LM. 1989. Development of the gastric barrier to acid. In Human Gastrointestinal Development, ed. E Lebenthal, pp. 353-63. New York: Raven
20. Dierichs R, Inczedy-Marcsek K. 1976. lodoplatinate as a marker of quarternary ammonium compounds in electron microscopy. J. Histochem. Cytochem. 24: 962-70
21. Dunjic BS, Axelson J, AriRajab A, Larsson K, Bengmark S. 1993. Gastroprotective capability of exogenous phosphalidylcholine in experimentally induced chronic gastric ulcers in rats. Scand. J. Gastroenterol. 28:89-94
22. Eliakim R, DeSchryver-Kecskemeti, Nogee L, Stenson WF, Alpers DH. 1989. Isolation and characterization of small intestinal surfactant-like particle containing alkaline phosphatase and other digestive enzymes. J. Biol. Chem. 264: 20614-19
23. Goddard PJ. 1990. Relation between acid back-diffusion and luminal surface hydrophobicity in canine gastric mucosa: effects of salicylate and prostaglandin. PhD thesis. Univ. Texas at Houston 147 pp.
24. Goddard PJ, Kao Y-CJ, Lichtenberger LM. 1990. Luminal surface hydrophobicity of canine gastric mucosa is dependent on a surface mucous gel. Gastroenterology 98:361-70
25. Goddard PJ, Lichtenberger LM. 1987. Does aspirin damage the canine gastric mucosa by reducing its surface hydrophobicity? Am. J. Physiol. 15: G421-30
26. Goggin PM, Marrero JM, Spychal RI, Jackson PA, Corbishley CM, Northfield TC. 1992. Surface hydrophobicity of gastric mucosa in Helicobacter pylori infection: effect of clearance and eradication. Gastroenterology 103:1486-90
27. Goggin PM, Northfield TC, Spychal RI. 1991. Factors affecting gastric mucosal hydrophobicity in man. Scand. J. Gastroenterol. 26(Suppl. 181):65-73
28. Gong D, Turner B, Bhaskar KR, Lamont JT. 1990. Lipid binding to gastric mucin: protective effect against oxygen radicals. Am. J. Physiol. 22:G681-86
29. Gundermann K-J, ed. 1993. The "Essential" Phospholipids as a Membrane Therapeutic, pp. 100-6, 167-74. Szcecin, Poland: Pol. Sect. Eur. Soc. Biochem. Pharmacol.
30. Gwpzdzinski K, Slomiany A, Nishikawa H. 1988. Gastric mucin hydrophobicity: effects of associated and covalently bound lipids, proteolysis, and reduction. Biochem. Int. 17:907-17
31. Heatley NG. 1959. Mucosubstances as a barrier to diffusion. Gastroenterology 37:313-17
32. Hentschel E, Brandstätter G, Dragosics B, Hirschl AM, Nemec H, et al. 1993. Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer. N. Engl. J. Med. 328:308-12
33. Hills BA. 1981. What is the true role of surfactant in the lung. Thorax 36:1-4
34. Hills BA. 1983. Water repellency induced by pulmonary surfactants. J. Physiol. 325:175-86
35. Hills BA. 1985. Gastric mucosal barrier: stabilization of hydrophobic lining to the stomach by mucus. Am. J. Physiol. 249:G342-49
36. Hills BA. 1988. Surfaces and surfactants. In The Biology of Surfactant, pp. 1-27. Cambridge: Cambridge Univ. Press.
37. Hills BA. 1990. A physical identity for the gastric mucosal barrier. Med. J. Aust. 153:76-81
38. Hills BA. 1991. A common physical basis for gastric mucosal barrier and the action of sucralfate. Am. J. Med. 91: 43S-51S
39. Hills BA. 1993. Gastric mucosal barrier: evidence for Helicobacter pylori ingesting gastric surfactant and deriving protection from it. Gut 34:588-93
40. Hills BA, Butler BD, Lichtenberger LM. 1983. Gastric mucosal barrier: the hydrophobic lining to the lumen of the stomach. Am. J. Physiol. 7:G561-68
41. Hills BA, Kirkwood CA. 1989. Surfactant approach to the gastric mucosal barrier: protection of rats by banana even when acidified. Gastroenterology 97:294-303
42. Hollander F. 1954. The two component mucus barrier. Arch. Int. Med. 93:107-20
43. Kalina M, Pease DC. 1977. The preservation of ultra-structure in saturated phosphatidylcholines by tannic acid in model systems and Type II pneumo-cytes. J. Cell Biol. 14:126-41
44. Kao Y-CJ, Goddard PJ, Lichtenberger LM. 1990. Morphological effects of aspirin and prostaglandin on the canine gastric mucosal surface: analysis with a phospholipid cytochemical stain. Gastroenterology 98:592-606
45. Kao Y-CJ, Lichtenberger LM. 1987. Localization of phospholipid-rich zones in rat gastric mucosa: possible origin of a protective hydrophobic lining. J. Histochem. Cytochem. 35:1285-98
46. Kao Y-CJ, Lichtenberger LM. 1990. Hydrophobic properties of the mucus cells of the stomach and submucosal glands. Gastroenterology 98:A67 (Abst.)
47. Kao Y-CJ, Lichtenberger LM. 1990. A method to preserve extracellular surfactant-like phospholipids on the luminal surface of the rodent gastric mucosa. J. Histochem. Cytochem. 38:427-31
48. Kao Y-CJ, Lichtenberger LM. 1991. Phospholipid-and neutral-lipid-containing organelles of rat gastroduodenal mucous cells. Gastroenterology 101:7-21
49. 2 on the lipidic organelles of rat gastric surface mucous cells. Gastroenterology 104:103-13
50. Kiviluto T, Paimela H, Mustonen H, Kivilaakso E. 1991. Effect of exogenous surface-active phospholipid on intracellular pH and membrane resistances in isolated Necturus antral mucosa exposed to luminal acid and barrier breaking agents. Gastroenlerology 100:38-46
51. Kivinen A, Salminen S, Homer D, Vapaatalo H. 1992. Gastroprotective effect of milk phospholipids, butter serum lipids and butter serum on ethanol and acetylsalicylic acid induced ulcers in rats. Michwissenschaft 47:573-75
52. Kivinen A, Tarpila S, Salminen S, Vapaatalo H. 1992. Gastroprotection with milk phospholipids: a first human study. Michwissenschaft 47:694-96
53. Kwun SY, Spychal RT. 1992. Ultra-structural identification of surfactant-like material in human esophageal mucosa. Gastroenterology 102:A104 (Abstr.)
54. 2 activity: a factor in peptic ulcer production? J. Clin. Pathol. 45: 221-24
55. Leyck S, Dereu N, Etschenberg E, Ghyczy M, Graf E, et al. 1985. Improvement of gastric tolerance of non-steroidal anti-inflammatory drugs by polyene phosphatidylcholine (Phospholipon R100). Eur. J. Pharmacol. 117:35-42
56. Lichtenberger LM, Ahmed TN, Barreto JC, Kao Y-O, Dial EJ. 1992. Use of fluorescent Hydrophobie dyes in establishing the presence of lipids in the gastric mucus gel layer. J. Clin. Gastroenterol. 14(Suppl. 1):582-87
57. Lichtenberger LM, Graziani LA, Dial EJ, Butler BD, Hills BA. 1983. Role of surface-active phospholipids in gastric cytoprotection. Science 219:1327-29
58. 2 on the surface hydrophobicity of aspirin-treated canine gastric mucosa. Gastroenterology 88: 308-14
59. Lichtenberger LM, Romero JJ. 1994. Effect of ammonium ion on the hydrophobic and barrier properties of the gastric mucus gel layer. J. Gastroenterol. Hepatol. In press
60. Lichtenberger LM, Wang ZM, Romero JJ, Barreto JC. 1994. Certain NSAIDs chemically associate with surface phospholipids: insight into mechanism and reversal of NSAID-induced gastric injury. Gastroenterology 106(4):A125 (Abst.)
61. Lugea A, Mourelle M, Guarner F, Domingo A, Salas A, Malagelada J-R. 1994. Mucosal secretion of phosphatidylcholines as mediators of adaptive cytoprotection of the rat duodenum. Gastroenterology. 107:720-27
62. Mack DR, Neumann AW, Policova Z, Sherman PM. 1992. Surface hydrophobicity of the intestinal tract. Am. J. Physiol. 262:G171-77
63. Mauch F, Bode G, Ditschuneit H, Malfertheiner P. 1993. Demonstration of a phospholipid-rich zone in the human gastric epithelium damaged by Helicobacter pylori. Gastroenterology 105:1698-704
64. Mobley HL, Cortesia M, Rosenthal LE, Jones BD. 1988. Characterization of urease from Campylobacter pylori. J. Clin. Microbiol. 26:831-36
65. Nardone G, D'Armieto F, Corso G, Civiletti C, Coscione P, et al. 1994. Lipids of human gastric mucosa: effect of inflammatory infiltrates. Helicobacter pylori infection and non-alcoholic cirrhosis. Gastroenterology. 107:362-68
66. Nishisaki H, Sakamoto C, Konda Y, Nakano O, Matozaki T, et al. 1992. Effects of antiulcer drags on phosphatidylcholine synthesis in isolated guinea pig gastric glands. Dig. Dis. Sci. 37:1593-99
67. Nishizawa Y, Sakurai H, Oketani K, Hone T, Yamato C, Moriga M. 1987. Effects of taurocholic acid/HCI alone or after pretreatment with geranylgera-nylacetone on phospholipid metabolism in rat gastric mucosa. Biochem. Pharmacol. 36:4111-17
68. Nishizawa Y, Sakurai H, Yamato C, Moriga M. 1987. Effects of ethanol alone or after pretreatment with 20% ethanol on phospholipid metabolism in rat gastric mucosa. Biochem. Biophys. Acta 917:372-80
69. Orchard JL, Bickerstaff CA. 1986. Gastric mucosal phospholipid concentrations in human patients with gastritis, gastric ulcer, and normals. Gastroenterology 90:A1573
70. Osler W. 1929. Beaumont's Experiments and Observations on the Gastric Juice and the Physiology of Digestion. Boston: Int. Physiol. Cong.
71. Ottletz A, Romero JJ, Hazell SL, Graham DY, Lichtenberger LM. 1993. Phospholipase activity of Helicobacter pylori and its inhibition by bismuth salts: Biochemical and biophysical studies. Dig. Dis. Sci. 38:2071-80
72. Padmanabham S, Bose A. 1988. Importance of direct measurement of dynamic contact angles during wetting of solids. J. Colloid Interface Sci. 126:164-70
73. Parnham MJ, Leyck S. 1988. Phospholipon 100. Drugs Future 13:324-25
74. Pfeiffer CJ. 1981. Experimental analysis of hydrogen ion diffusion in gastro-intestinal mucus glycoprotein. Am. J. Physiol. 3:G176-82
75. Ridel E. 1967. Wetting. Soc. Chem. Ind. monogragraph 25. London: Soc. Chem. Ind.
76. Robért A, Nezamis JE, Lancaster C, Daries JP, Field SO, Hanchar AJ. 1983. Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins. Am. J. Physiol. 245:G113-21
77. Robert A, Nezamis JE, Lancaster C, Hanchar AJ. 1979. Cytoprotection by prostaglandins in rats: Prevention of gastric necrosis produced by alcohol, HCI, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 70:359-70
78. Romero JJ, Carryl O, Lichtenberger LM. 1994. Spice rapidly attenuates the hydrophobic lining of the rat stomach. Gastroenterology 106(4):A167 (Abst.)
79. Romero JJ, Kao Y-CJ, Lichtenberger LM. 1990. Gastric protective activity of mixtures of polar and neutral lipids in rats. Gastroenterology 99:311-26
80. Sbarbati A, Deganello A, Tamassia G, Bertini M, Gaburro D, Osculati F. 1992. Surfactant-like material in the antral mucosa of children. J. Pediatr. Gastroenterol. 13:279-84
81. Scheiman JM, Kraus ER, Boland CR. 1992. Regulation of canine gastric mucin synthesis and phospholipid secretion by acid secretagogues. Gastroenterology 103:1842-50
82. 2-induced secretion of surfactant phospholipid by isolated gastric mucous cells. Gastroenterology 100:1232-40
83. Schmitz MGJ, Renooij W. 1990. Phospholipids from rat, human, and canine gastric mucosa. Gastroenterology 99: 1292-96
84. Sengupta S, Piotrowski E, Slomiany A, Slomiany BL. 1991. Role of adrenergic and cholinergic mediators in gastric mucus phospholipid secretion. Biochem. Int. 24:1145-53
85. Slomiany A, Galicki NI, Kojima K, Baras-Grnszka Z, Slomiany BL. 1981. Glyceroglucolipids of the mucous barrier of dog stomach. Biochim. Biophys. Acta 665:88-91
86. Slomiany A, Jozwiak Z, Takagi A, Slomiany BL. 1984. The role of covalently bound fatty acids in the degradation of human gastric mucus glycoprotein. Arch. Biochem. 229:560-67
87. Slomiany BL, Kasinathan C, Slomiany A. 1989. Lipolytic activity of Campylobacter pylori: effect of colloidal bismuth subcitrate (De-Nol). Am. J. Gastroenterol. 84:1273-77
88. Slomiany BL, Sarosiek J, Slomiany A. 1987. Gastric mucus and the mucosal barrier. Dig. Dis. Sci. 5:125-45
89. Slomiany BL, Slomiany A. 1991. Role of mucus in gastric mucosal protection. J. Physiol. Pharmacol. 42:141-61
90. Slomiany A, Yano S, Slomiany BL, Glass GBJ. 1978. Lipid composition of the gastric mucous barrier in the rat. J. Bio/. Chem. 253:3785-91
91. Spychal RT, Goggin PM, Marrero JM, Saverymuttu SH, Yu CW, et al. 1990. Surface hydrophobicity of gastric mucosa in peptic ulcer disease: relationship to gastritis and Campylobacter pylori infection. Gastroenterology 98:1250-54
92. Spychal RT, Marrero JM, Saverymuttu SH, Northfield TC, 1989. Measurement of the surface hydrophobicity of human gastrointestinal mucosa. Gastroenterology 97:104-11
93. Swam RA, Ashley SW, Soybel DI, Ordway FS, Cheung LY. 1987. Protective effect of exogenous phospholipid on aspirin-induced gastric mucosal injury. Am. J. Surg. 153:48-53
94. Tatsumi Y, Lichtenberger LM. 1994. Trinitrobenzensulfonic acid (TNBS) reduces colonic mucosal hydrophobicity by formation of a complex with zwitterionic phospholipids. Gastroenterology. 106:A781 (Abstr.)
95. Tietze CC, Becich MJ, Engle M, Stenson WF, Eliakim R, Alpers DH. 1992. Surfactant-like particle production by Caco-2 cells is stimulated by tranfection with rat intestinal alkaline phosphatase cDNA. Am. J. Physiol. 263:G756-66
96. Walsbren SJ, Gelbel JP, Modlin IM, Boron WF. 1994. Unusual permeability properties of gastric gland cells. Nature 368:332-34
97. Wassef MK, Lin YN, Horowitz MI. 1978. Phospholipid-deacylating enzymes of rat stomach mucosa. Biochim. Biophys. Acta 528:318-30
98. Wassef MK, Lin YN, Horowitz MJ. 1979. Molecular species of phosphatidylcholine from rat gastric mucosa. Biochim. Biophys. Acta 573:222-26
99. Weberg R, Berstad K, Berstad A. 1990. Acute effects of antacids on gastric juice components in duodenal ulcer patients. Eur. J. Clin. Invest. 20:511-15
100. Weit Kamp J-H, Perez-Perez GI, Bode G, Blaser MJ. 1992. Characteristics of Helicobacter pylori phospholipase C activity. Gastroenterology 102:A946 (Abst.)
101. Wertz PW, Downing DT. 1982. Glycolipids in mammalian epidermis: structure and function in the water barrier. Science 217:1261-62
102. Williams SE, Turnburg LA. 1980. Retardation of acid diffusion by pig gastric mucus: a potential role in mucosal protection. Gastroenterology 79:299-304
103. Wolfe S. 1965. Gastric secretions. In The Stomach. pp. 53-79. New York: Oxford Univ. Press