Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture

Journal of Clinical Investigation

Volumn 95, Issue 5, 1995, Pages 1994-2003

  Takahashi, Morio ^a   Ota, Shinichi ^d   Shimada, Tadato ^d   Hamada, Eiji ^d   Kawabe, Takao ^d   Okudaira, Takehito ^d   Matsumura, Masayuki ^a   Kaneko, Nobuyuki ^a   Terano, Akira ^b   Nakamura, Toshikazu ^c   Omata, Masao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Dokkyo University   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^d NONE

Author keywords

gastric epithelial cell; hepatocyte growth factor; Northern blot hybridization; proliferation; restitution

Indexed keywords

CYCLOHEXIMIDE; DNA; EPIDERMAL GROWTH FACTOR; IMMUNOGLOBULIN G; INSULIN; MESSENGER RNA; RABBIT ANTISERUM; RECOMBINANT SCATTER FACTOR; SCATTER FACTOR;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; FETAL CALF SERUM; FIBROBLAST; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; MONOLAYER CULTURE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RABBIT; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH EPITHELIUM; STOMACH ULCER; ULCER HEALING;

EID: 0028914930     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117884     Document Type: Article

References (46)

1. Myhre, E. 1960. Regeneration of the fundic mucosa in rats. Arch. Pathol. 70:476-485.
2. Chen, M. C., A. T. Lee, and A. H. Soll. 1991. Mitogenic response of canine fundic epithelial cells in short-term culture to transforming growth factor a and insulin-like growth factor 1. J. Clin. Invest. 87:1716-1723.
3. Rutten, M. J., P. Harmon, and D. R. Campbell. 1991. Insulin enhances epidermal growth factor- and transforming growth factor alpha-stimulated growth in primary cultures of guinea pig gastric mucous epithelial cells. Scand. J. Gastroenterol. 26:965-973.
4. Rutten, M. J., P. J. Dempsey, T. E. Solomon, and J. R. J. Coffey. 1993. TGF-α is a potent mitogen for primary cultures of guinea pig gastric mucous epithelial cells. Am. J. Physiol. 265 (Gastrointest. Liver Physiol. 28):G361-G369.
5. Yoshiura, K., S. Ota, A. Terano, M. Takahashi, Y. Hata, T. Kawabe, H. Mutoh, H. Hiraishi, R. Nakata, K. Okano, and M. Omata. 1994. Growth regulation of rabbit gastric epithelial cells and protooncogene expression. Dig. Dis. Sci. 39:1454-1463.
6. Polk, W. H., Jr., P. J. Dempsey, W. E. Russell, P. I. Brown, R. D. Beauchamp, J. A. Barnard, and J. R. J. Coffey. 1992. Increased production of transforming growth factor a following acute gastric injury. Gastroenterology. 102:1467-1474.
7. Beauchamp, R. D., J. A. Barnard, C. M. MacCuthen, J. A. Cherner, and R. J. Coffey. 1989. Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal. J. Clin. Invest. 83:1017-1023.
8. Folkman, J., S. Szabo, and P. Vattay. 1990. Effect of oral administration of bFGF on healing of chronic duodenal ulcers, gastric secretion and acme mucosal lesions in rats. Gastroenterology. 98:45.
9. Szabo, S., P. Vattay, and R. E. Morales. 1989. Orally administered FGF mutein: effect on healing of chronic duodenal ulcers in rats. Dig. Dis. Sci. 34:1323.
10. Folkman, J., S. Szabo, M. Stovroff, P. MacNeil, W. Li, and Y. Shing. 1991. Duodenal ulcer. Discovery of a new mechanism and development of angiogenic therapy that accelerates healing. Ann. Surg. 214:414-427.
11. Morris, G. P., and J. L. Wallace. 1981. The roles of ethanol and of acid in the production of gastric erosions in rats. Virchow's Arch. B. 38:23-28.
12. Wang, J. Y., and L. R. Johnson. 1989. Induction of gastric and duodenal mucosal ornithine decarboxylase during stress. Am. J. Physiol. 257 (Gastrointest. Liver Physiol. 20):G259-G265.
13. Rutten, M. J., and S. Ito. 1983. Morphology and electrophysiology of guinea pig gastric mucosal repair in vitro. Am. J. Physiol. 257 (Gastrointest. Liver Physiol. 7):G171-G183.
14. Silen, W. 1983. Gastric mucosal defence and repair. In Physiology of the Gastrointestinal Tract. Second edition. L. R. Johnson, editor. Raven Press, New York. 1055-1069.
15. Silen, W., and S. Ito. 1985. Mechanisms for rapid re-epithelialization of the gastric mucosal surface. Ann. Rev. Physiol. 47:217-229.
16. Yeomans, N. D., D. J. B. S. John, and W. G. Deboer. 1973. Regeneration of gastric mucosa after aspirin-induced injury to the rat. Am. J. Dig. Dis. 18:773-780.
17. Nakamura, T. 1991. Structure and function of hepatocyte growth factor. Prog. Growth Factor Res. 3:67-85.
18. Matsumoto, K., and T. Nakamura. 1992. Hepatocyte growth factor: Molecular structure, roles in liver regeneration, and other biological functions. Crit. Rev. Oncogenesis. 3:27-54.
19. Igawa, T., S. Kanda, and H. Kanetake. 1991. Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epithelial cells. Biochem. Biophys. Res. Commun. 174:831-838.
20. Matsumoto, K., H. Tajima, and T. Nakamura. 1991. Hepatocyte growth factor is a potent stimulator for human melanocytes. Biochem. Biophys. Res. Commun. 176:45-51.
21. Matsumoto, K., K. Yoshikawa, and T. Nakamura. 1991. Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor. Exp. Cell. Res. 196:114-120.
22. Kinoshita, T., K. Tashiro, and T. Nakamura. 1989. Marked increase of HGF mRNA in non-parenchymal liver cells of rats treated with hepatotoxins. Biochem. Biophys. Res. Commun. 165(3):1229-1234.
23. Noji, S., K. Tashiro, E. Koyama, T. Nohno, K. Ohyama, S. Taniguchi, and T. Nakamura. 1990. Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat liver, as revealed by in situ hybridization. Biochem. Biophys. Res. Commun. 173:42-47.
24. DiRenzo, M. F., R. P. Narsimhan, M. Olivero, S. Bretti, S. Giordano, E. Medico, P. Gaglia, P. Zara, and P. M. Comoglio. 1991. Expression of the Met/HGF receptor in normal and neoplastic human tissues. Oncogene. 6:1997-2003.
25. Takahashi, M., S. Ota, A. Terano, K. Yoshiura, M. Matsumura, Y. Niwa, T. Kawabe, T. Nakamura, and M. Omata. 1993. Hepatocyte growth factor induces mitogenic reaction to the rabbit gastric epithelial cells in primary culture. Biochem. Biophys. Res. Commun. 191:528-534.
26. Nakamura, T., T. Nishizawa, M. Hagiya, T. Seki, M. Shimonishi, A. Sugimura, K. Tashiro, and S. Shimizu. 1989. Molecular cloning and expression of human hepatocyte growth factor. Nature (Lond.). 342:440-443.
27. Zarnegar, R., S. Muga, R. Rahija, and G. Michalopoulos. 1990. Tissue distribution of hepatopoietin-A: a heparin-binding polypeptide growth factor for hepatocytes. Proc. Natl. Acad. Sci. USA. 87:1252-1256.
28. Ota, S., A. Terano, and H. Hiraishi. 1990. A monolayer culture of gastric mucous cells from adult rabbits. Gastroenterol. Jpn. 25:1-7.
29. Terano, A., K. J. Ivey, and J. Stachra. 1982. Cell culture of rat gastric fundic mucosa. Gastroenterology. 83:1280-1291.
30. Nachlas, M. M., K. C. Tsou, and E. D. Souda. 1957. Cytochemical demonstration of succinic dehydrogenase by the use of a new p-nitrophenyl substituted ditetrazole. J. Histochem. Cytochem. 15:420-436.
31. Bowie, D. J. 1935. A method for staining the pepsinogen granules of gastric glands. Anat. Rec. 64:357.
32. Higuchi, O., and T. Nakamura. 1991. Identification and change in the receptor for hepatocyte growth factor in rat liver after partial hepatectomy or induced hepatitis. Biochem. Biophys. Res. Commun. 176:599-607.
33. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
34. Tashiro, K., M. Hagiya, T. Nishizawa, T. Seki, M. Shimonishi, S. Shimizu, and T. Nakamura. 1990. Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues. Proc. Natl. Acad. Sci. USA. 87:3200.
35. Tsao, M., H. Zhu, A. Giaid, J. Viallet, T. Nakamura, and M. Park. 1993. Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial and lung carcimoma. Cell Growth & Differ. 4:571-579.
36. Sato, Y., K. Mukai, S. Watanabe, M. Goto, and Y. Shimosato. 1986. The AMeX method: a simplified technique of tissue processing and paraffin embedding with improved preservation of antigens for immunostaining. Am. J. Pathol. 125:431-435.
37. Yoshinaga, Y., Y. Matsuno, S. Fujita, T. Nakamura, M. Kikuchi, Y. Shimosato, and S. Hirohashi. 1993. Immunohistochemical detection of hepatocyte growth factor/scatter factor in human cancerous and inflammatory lesions of various organs. Jpn. J. Cancer Res. 84:1150-1158.
38. Sporn, M. B., and A. B. Roberts. 1993. A major advance in the use of growth factors to enhance wound healing. J. Clin. Invest. 92:2565-2566.
39. Lynch, S. E., R. B. Colvin, and H. N. Antoniades. 1989. Growth factors in wound healing. J. Clin. Invest. 84:640-646.
40. McCormack, S., A., M. J. Viar, and L. R. Johnson. 1992. Migration of IEC-6 cells: a model for mucosal healing. Am. J. Physiol. 263 (Gastrointest. Liver Physiol. 26):G426-G435.
41. Nursat, A., A. C. Parkos, E. A. Bacarra, J. P. Godowski, C. Delp-Archer, M. E. Rosen, and L. J. Madara. 1994. Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junction on transformed and non-transformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium. J. Clin. Invest. 93:2056-2065.
42. Prat, M., R. P. Narsimhan, T. Crepaldi, M. R. Nicotra, P. G. Natali, and P. M. Comoglio. 1991. The recepor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors. Int. J. Cancer. 49:323-328.
43. Konturek, J. W., W. Bielanski, S. J. Konturek, J. Bogdal, and J. Oleksy. 1989. Distribution and release of epidermal growth factor in man. Gut. 30:1194-1200.
44. Chen, M. C., A. T. Lee, W. E. Karmes, D. Avedian, M. Martin, J. M. Sorvillo, and A. H. Soll. 1993. Paracrine control of gastric epithelial cell growth in culture by transforming growth factor-α. Am. J. Physiol. 264 (Gastrointest. Liver Physiol. 27):G390-G396.
45. Yanagita, K., M. Nagaike, H. Ishibashi, Y. Niho, K. Matsumoto, and T. Nakamura. 1992. Lung may have an endocrine function producing hepatocyte growth factor in response to injury of distal organ. Biochem. Biophys. Res. Commun. 182:802-809.
46. Szabo, S. 1991. Mechanism of gastric mucosal injury and protection. J. Clin. Gastroenterol. 13 Suppl 2:S21-34.