DNA repair by ogt alkyltransferase influences EMS mutational specificity

Carcinogenesis

Volumn 16, Issue 4, 1995, Pages 817-821

  Vidal, Antonio ^a   Abril, Nieves ^a   Pueyo, Carmen ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; GUANINE; MESYLIC ACID ETHYL ESTER; TRANSFERASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA SEQUENCE; ESCHERICHIA COLI; EXCISION REPAIR; GENE MUTATION; MUTAGENESIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL;

BACTERIAL PROTEINS; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; DNA REPAIR; ETHYL METHANESULFONATE; GENES, BACTERIAL; LAC OPERON; METHYLTRANSFERASES; MOLECULAR SEQUENCE DATA; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SENSITIVITY AND SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0028913876     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/16.4.817     Document Type: Article

References (25)

1. Singer, B. and Grunberger D. (1983) Molecular Biology of Mutagens and Carcinogens. Plenum Press, New York, NY, pp. 55-68.
2. Loveless, A. (1969) Possible relevance of 06-alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosoamides. Nature, 223, 206-207.
3. Pegg A.E. and Singer, B. (1984) Methylation of the 0-6 position of guanine in DNA is the most likely initiating event in carcinogenesis by alkylating agents. Cancer. Invest, 2, 221-236.
4. Horsfall, M.J., Gordon, AJ.E., Bums, P.A., Zielensk M., van der Vliet, G.M.E. and Glickman B.W. (1990) Mutational specificity of alkylating agents and the influence of DNA repair. Environ. Mol. Mutagen., 15, 107-122.
5. Potter, P.M., Wilkinson, M.C., Fitton J., Carr F.J., Brcnnand J., Cooper, D.P. and Margison, G.P. (1987) Characterisation and nucleotide sequence of ogt CAalkylguanine-DNA-alkyltransferase gene of E.coli. Nucleic Acids Res., 15, 9177-9193.
6. Rebeck, G.W., Coons, S., Carroll, P. and Samson, L. (1988) A second DNA methyltransferase repair enzyme in Escherichia coli. Proc. Natl Acad. Sci. USA, 85, 3039-3043
7. Samson, L. and Caims J. (1977) A new pathway for DNA repair in Escherichia coli. Nature (Lond), 267, 281-282.
8. Schendel P.F. and Robins, P.E. (1978) Repair of CAmethylguanine in adapted Escherichia coli. Proc. Natl Acad. Sci. USA, 12, 6017-6020.
9. Teo, L., Sedgwick, B., Demple B., Li, B. and Lindahl, T. (1984) Induction of resistance to alkylating agents in E.coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage. EMBO J„ 3, 2151-2157.
10. Wilkinson, M.C., Potter, P.M., Cawkwell L., Georgiadis P, Patel, D., Swann, P.F. and Margison G.P. (1989) Purification of the E.coli ogt gene product to homogeneity and its rate of action on CAmcthylguanine, CAethylguanine and Cf*-methylthymine in dodecadeoxyribonucleotides. Nucleic Acids Res., 17, 8475-8484.
11. Abril, N., Roldin-Aijona, T., Prieto-Alamo, M-.J., van Zeeland, A.A. and Pueyo C. (1992) Mutagenesis and DNA repair for alkylation damages in Escherichia coli K-12. Environ. Mol. Mutagen., 19, 288-290.
12. Abril, N., Hera, C., Alejandre E., Rafferty J.A., Margison G.P. and Pueyo C. (1994) Effect of ogt expression on mutation induction by methyl-, ethyl- and propylmethanesulphonate in Escherichia coli K-12 strains. Mol. Gen. Genet., 242, 744-748.
13. Rebeck, G.W. and Samson J-. (1991) Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6- methylguanine DNA repair methyltransferase. J. Bacteriol., 173, 2068-2076.
14. Samson, L., Thomale J. and Rajewsky M.F. (1988) Alternative pathways for the in vivo repair of CAalkylguanine and (74-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair. EMBO J„ 7, 2261-2267.
15. Kohda, K.H., Ninomiya, S., Washizu K., Shiraki K., Ebie, M. and Kawazoe Y. (1987) Mutagenicity of a series of W-alkyl-, N-hydroxy- alkyl-, iV-haloalkyl- and A-carboxy-alkyl-N-nitrosoureas in Escherichia coli tester strains: dependence on the uvrA DNA-repiair system. Mutat. Res., 77, 219-220.
16. Bums P.A., Allen, F.L. and Glickman B.W. (1986) DNA sequence analysis of mutagenicity and site specificity of ethyl methanesulphonate in Uvr+ and Uvr- strains of Escherichia coli. Genetics, 113, 811-819.
17. Curtis, R. (1981) Gene transfer. In Gerhardt.P. (ed.), Manual of Methods for General Bacteriology. American Society for Microbiology, Washington, DC, pp. 243-266.
18. Miller J.H. (1972) A Short Course in Bacterial Genetics. A Laboratory Manual and a Handbook for Escherichia coli and Related Bacteria. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
19. Davis, R.W., Botstein D. and Roth J.R. (1980) A Manual for Genetic Engineering. Advanced Bacterial Genetics. Cold Spiring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 201-206.
20. Millerj H. (1992) Experiments in Molecular Genetics. Cold Spring Harbor Laboratory Press, Cold Spiring Harbor, NY.
21. Hera, C. and Pueyo C. (1986) Conditions for the opitimal use of the L-arabinose-resistance mutagenesis test with Salmonella typhimurium. Mutagenesis, 1, 267-273.
22. Schaapier R.M., Danforth B.N. and Glickman B.W. (1985) Rapid repeated cloning of mutant lac repiressor genes. Gene, 39, 181-189.
23. Pienkowska, M, Glickman B.W., Ferreira, A., Anderson, M. and Zielenska, M. (1993) Large-scale mutational analysis of EMS-induced mutation in the lacl gene of Escherichia coli. Mutat. Res., 288, 123-131.
24. Bums, P.A., Gordon, A.J.E., Kunsmann K. and Glickman B.W. (1988) Influence of neighbouring base sequence on the distribution and repiair of A'-ethyl-W-nitrosourea-induced lesions in Escherichia coli. Cancer. Res., 48, 4455-4458.
25. Oiler, A.R., Fijalkowska J.J., Dunn R.L. and Schaapier JCM. (1992) Transcription-repiair coupling determines the strandedness of ultraviolet mutagenesis in Escherichia coli. Proc. Natl Acad. Sci. USA, 89, 11036-11040.