Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus

Journal of Clinical Investigation

Volumn 95, Issue 3, 1995, Pages 1032-1039

  Alarcón, Cristina ^a   Leahy, Jack L ^b   Schuppin, George T ^a   Rhodes, Christopher J ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b TUFTS UNIVERSITY   (United States)

^c JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYPEPTIDASE H; PROINSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE CONVERSION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SECRETORY GRANULE;

EID: 0028912883     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117748     Document Type: Article

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