Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice

Journal of Experimental Medicine

Volumn 181, Issue 2, 1995, Pages 569-575

  Abraham, Edward ^a   Bursten, Stuart ^c   Shenkar, Robert ^a   Allbee, Janet ^a   Tuder, Rubin ^a   Woodson, Paul ^c   Guidot, David M ^b   Rice, Glenn ^c   Singer, Jack W ^c   Repine, John E ^a,b  

^a Division of Pulmonary Sciences and Critical Care Medicine   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c Cell Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL[ACYL CARRIER PROTEIN] PHOSPHOLIPID ACYLTRANSFERASE; ACYL[ACYL CARRIER PROTEIN] PHOSPHOLIPID ACYLTRANSFERASE INHIBITOR; ENZYME INHIBITOR; LISOFYLLINE; PHOSPHATIDIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPOXIA; LUNG HEMORRHAGE; LUNG INJURY; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACYLTRANSFERASES; ANIMAL; CELL ADHESION; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; HEMORRHAGE; HUMAN; INFLAMMATION; LUNG; MICE; PENTOXIFYLLINE; PHOSPHATIDIC ACIDS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028912627     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.181.2.569     Document Type: Article

References (32)

1. Repine, J.E. 1992. Scientific perspectives on Adult Respiratory Distress Syndrome. Lancet 339: 466-469.
2. Shenkar, R., W.F. Coulson, and E. Abraham. 1994. Hemorrhage and resuscitation induce alterations in cytokine expression and the development of acute lung injury. Am.J. Respir. Cell Mol. Biol. 10: 290-297.
3. Hoch, R.C., R. Rodriguez, T. Manning, W.C. Shoemaker, and E. Abraham. 1993. Effects of accidental trauma on cytokine and endotoxin production. Crit. Care Med. 21: 839-845.
4. Shenkar, R., and E. Abraham. 1993. Effects of hemorrhage on cytokine gene transcription. Lymphokine Cytokine Res. 12: 237-247.
5. Law, M.M., H.G. Cryer, and E. Abraham. 1993. Elevated serum levels of ICAM-1, but not TNF-receptor correlate with the development of multiple organ failure in trauma patients. J. Trauma 25:165.
6. Zoeller, R.A., P.D. Wightman, M.S. Anderson, and C.R. Raetz. 1987. Accumulation of lysophosphatidylinositol in RAW264.7 macrophage tumor cells stimulated by lipid A precursors. J. Biol. Chem. 262: 17212-17219.
7. Bursten, S.L., W.E. Harris, K. Bomsztyk, and D. Lovett. 1991. Interleukin rapidly stimulates lysophosphatidate acyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells. J. Biol. Chem. 266: 20732-20743.
8. Rice, G.C., P. Brown, R. Nelson, J. Bianco, J. Singer, and S.L. Bursten. 1994. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proc. Natl. Acad. Sci. USA. 91: 3857-3861.
9. Bursten, S.L., W.E. Harris, K. Resch, and D.H. Lovett. 1992. Lipid A activation of glomerular mesangial cells: mimicry of the bioactive lipid, phosphatidic acid. Am.J. Physiol. 262(Cell Phys. 31) C328-C338.
10. Rice, G.C., J. Rosen, R. Weeks, J. Michnick, J.A. Bianco, and J.W. Singer. 1994. CT1501R selectively inhibits induced inflammatory monokines in human whole blood ex viva Shock. 1: 254-266.
11. Agwu, D.E., L.C. McPhail, S. Sozzani, D.A. Bass, and C.E. McCall. 1991. Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effect on activation of NADPH oxidase. J. Clin. Invest. 88: 531-540.
12. Repine, J.E., and C.C. Clawson. 1978. Influence of surface proteins and separation techniques on neutrophil unstimulated and stimulated locomotion in vitro. J. Reticuloendothel. Soc. 24: 217-226.
13. Rasp, F.L., C.C. Clawson, J.R. Hoidal, and J.E. Repine. 1979. Quantitation and scanning electron microscopic comparison of human alveolar macrophage and polymorphonuclear leukocyte adherence to nylon fibers in vitra J. Reticuloendothel. Soc. 25: 101-109.
14. Berger, E.M., R.N. Harada, A.E. Vatter, C.M. Bowman, and J.E. Repine. 1984. Cyclical abnormalities in the bactericidal function, superoxide anion production and lysozyme activity of neutrophils obtained from a healthy woman during menstruation. J. Infectious Dis. 149: 413-419.
15. Robinson, A., and E. Abraham. 1991. Effects of hemorrhage and resuscitation on bacterial antigen specific pulmonary plasma cell function. Crit. Care Med. 19: 1285-1293.
16. Abraham, E., A.A. Freitas, and A.A. Coutinho. 1990. Purification and characterization of intraparenchymal lung lymphocytes. J. Immunol. 144: 2117-2222.
17. Kawasaki, E.S. 1991. Amplification of RNA. In PCR Protocols: A Guide to Methods and Applications. M.A. Innis, D.H. Gel-fand, J.J. Sninsky, and T.J. White, editors. Academic Press, New York. 2-3.
18. Siebert, P.D., and J.W. Larrick. 1993. PCR Mimics: competitive DNA fragments for use as internal standards in quantitative PCR. Biotechniques 14: 244-249.
19. Abraham, E., and S. Fink. 1986. Cardiorespiratory and conjunctival oxygen tension monitoring during resuscitation from hemorrhage. Crit. Care Med. 14: 1004-1009.
20. Hyers, T.M., S.M. Tricomi, P.A. Dettenmeier, and A.A. Fowler. 1991. Tumor necrosis factor levels in serum andbronchoalveolar lavage fluid of patients with the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 144: 268-271.
21. Suter, P.M., S. Suter, E. Girardin, P. Roux-Lombard, G.E. Grau, and J.M. Dayer. 1992. High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am. Rev. Respir. Dis. 145: 1016-1022.
22. Nishizuka, Y. 1992. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (Wash. DC). 258: 607-614.
23. Bocckino, S.B., P.B. Wilson, andJ.H. Exton. 1991. Phospha-tidate-dependent protein phosphorylation. Proc. Natl. Acad. Sci. USA. 88: 6210-6213.
24. Tsai, M.-H., C.-L. Yu, F.-S. Wei, and D.W. Stacey. 1989. The effect of GTPase activating protein upon ras is inhibited by mitogenically responsive lipids. Science (Wash. DC). 243: 522-526.
25. Moolenaar, W.H., W. Kruijer, B.C. Tilly, I. Verlaan, A.J. Bierman, and S.W. deLaat. 1986. Growth factor-like action of phosphatidic acid. Nature (Land.). 323: 171-173.
26. Altin, J.G., and F. Bygrave. 1987. Phosphatidic acid and aracha-donic acid each interact synergistically with glucagon to stimulate Ca+2 influx in the perfused liver. Biochem.J. 247: 613-619.
27. Rnauss, T.C., F.E. Jaffer, and H.E. Abboud. 1990. Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C. J. Biol. Chem. 265: 14457-14463.
28. Bursten, S., R. Weeks, J. West, T. Le, T. Wilson, D. Porubek, J.A. Bianco, J.W. Singer, and G.C. Rice. Potential role for phosphatidic acid in mediating the inflammatory responses to TNFa and IL-1β. Circ. Shock. In press.
29. Moolenaar, W.H. 1994. LPA: a novel lipid mediator with diverse biological actions. Trends Cell Biol. 4: 213-218.
30. +-activated CI" current in Xenopus laevis oocytes. Am. J. Physiol. 263:C896-C900.
31. Aviram, M., and I. Maor. 1993. Phospholipase D-modified low density lipoprotein is taken up by macrophages at increased rate. A possible role for phosphatidic acid. J. Clin. Invest. 91: 1942-1952.
32. Arend, W.P. 1993. Interleukin-1 receptor antagonist. Adv. Immunol. 54: 167-227.