Selective apoptosis of cd4+ cd8+ thymocytes by the anti-fas antibody

Journal of Experimental Medicine

Volumn 181, Issue 2, 1995, Pages 485-491

  Ogasawara, Jun ^a,b   Suda, Takashi ^a   Nagata, Shigekazu ^a  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b OSAKA CITY INSTITUTE OF PUBLIC HEALTH AND ENVIRONMENTAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CELL SURFACE PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CYTOTOXICITY; GENE EXPRESSION; GENE MUTATION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE;

ANIMAL; ANTIGENS, CD4; ANTIGENS, CD8; ANTIGENS, CD95; ANTIGENS, SURFACE; APOPTOSIS; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; HAMSTERS; MICE; MICE, INBRED BALB C; SUPPORT, NON-U.S. GOV'T; THYMUS GLAND;

EID: 0028912626     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.181.2.485     Document Type: Article

References (42)

1. Schwartz, R.H. 1989. Acquisition of immunologic tolerance. Cell. 57: 1073-1081.
2. von Boehmer, H. 1994. Positive selection of lymphocytes. Cell. 76: 219-228.
3. Nossal, G.J.V. 1994. Negative selection of lymphocytes. Cell. 76: 229-239.
4. Webb, S., C. Morris, and J. Sprent. 1990. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell. 63: 1249-1256.
5. Watanabe-Fukunaga, R., C.I. Brannan, N. Itoh, S. Yonehara, N.G. Copeland, N.A. Jenkins, and S. Nagata. 1992. The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J. Immunol. 148: 1274-1279.
6. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell. 66: 233-243.
7. Nagata, S. 1994. Fas and Fas ligand: a death factor and its receptor. Adv. Immunol. 57: 129-144.
8. Ogasawara, J., R. Watanabe-Fukunaga, M. Adachi, A. Mat-suzawa, T. Kasugai, Y. Kitamura, N. Itoh, T. Suda, and S. Nagata. 1993. Lethal effect of the anti-Fas antibody in mice. Nature (Lond.). 364: 806-809.
9. Suda, T., T. Takahashi, P. Golstein, and S. Nagata. 1993. Molecular cloning and expression of the Fas ligand: a novel member of the tumor necrosis factor family. Cell. 75: 1169-1178.
10. Suda, T., and S. Nagata. 1994. Purification and characterization of the Fas ligand that induces apoptosis. J. Exp. Med. 179: 873-878.
11. Trauth, B.C., C. Klas, A.M.J. Peters, S. Matzuku, P. Moller, W. Falk, K.-M. Debatin, and P.H. Krammer. 1989. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science (Wash. DC). 245: 301-305.
12. Yonehara, S., A. Ishii, and M. Yonehara. 1989. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169: 1747-1756.
13. Watanabe-Fukunaga, R., C.I. Brannan, N.G. Copeland, N.A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (Lond.). 356: 314-317.
14. Takahashi, T., M. Tanaka, C.I. Brannan, N.A. Jenkins, N.G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lym-phoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 76: 969-976.
15. Adachi, M., R. Watanabe-Fukunaga, and S. Nagata. 1993. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of Ipr mice. Proc. Natl. Acad. Sci. USA. 90: 1756-1760.
16. Cohen, P.L., and R.A. Eisenberg. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9: 243-269.
17. Sambrook, J., E.F. Fretsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
18. Zhou, T., H. Bluethmann, J. Eldridge, K. Berry, and J.D. Mountz. 1993. Origin of CD4-CD8"B220+ T cells in MRL-Ipr/lpr mice. J. Immunol. 150: 3651-3667.
19. Herron, L.R., R.A. Eisenberg, E. Roper, V.N. Kakkanaiah, P.L. Cohen, and B.L. Kotzin. 1993. Selection of the T cell receptor repertoire in Lpr mice. J. Immunol. 151: 3450-3459.
20. Cohen, J.J., and R.C. Duke. 1984. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132: 38-42.
21. Kizaki, H., T. Tadakuma, C. Odaka, J. Muramatsu, and Y. Ishimura. 1989. Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters. J. Immunol. 143: 1790-1794.
22. McConkey, D.J., P. Nicotera, P. Hartzell, G. Bellomo, A.H. Wyllie, and S. Orrenius. 1989. Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration. Arch. Biochem. Biophys. 269: 365-370.
23. Murphy, K.M., A.B. Heimberger, and D.Y. Loh. 1990. Induction by antigen of intrathymic apoptosis of CD4+CD8 + TCR’° thymocytes in vivo. Science (Wash. DC). 250: 1720-1723.
24. Smith, C.A., G.T. Williams, R. Kingston, E.J. Jenkinson, and J.J.T. Owen. 1989. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature (Lond.). 337: 181-184.
25. Drappa, J., N. Brot, and K.B. Elkon. 1993. The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL Ipr/lpr. Proc. Natl. Acad. Sci. USA. 90: 10340-10344.
26. Leithauser, F., J. Dhein, G. Mechtersheimer, K. Koretz, S. Briiderlein, C. Henne, A. Schmidt, K.-M. Debatin, P.H. Krammer, and P. Moller. 1993. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lai i Invest. 69: 415-429.
27. Debatin, K.-M., D. Suss, and P.H. Krammer. 1994. Differential expression of APO-1 on human thymocytes: implications for negative selection? Eur. J. Immunol. 24: 753-758.
28. Blackman, M., J. Kappler, and P. Marrack. 1990. The role of the T cell receptor in positive and negative selection of developing T cells. Science (Wash. DC). 248: 1335-1341.
29. Russell, J.H., B. Rush, C. Weaver, and R. Wang. 1993. Mature T cells of autoimmune Ipr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. USA. 90: 4409-4413.
30. Russell, J.H., and R. Wang. 1993. Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells. Eur. J. Immunol. 23: 2379-2382.
31. Shi, Y., R.P. Bissonnette, N. Parfey, M. Szalay, andD.R. Green. 1991. In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J. Immunol. 144: 3326-3346.
32. Strasser, A., A.W. Harris, and S. Cory. 1991. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell. 67: 889-899.
33. Sentman, C.L., J.R. Shutter, D. Hockenbery, O. Kanagawa, and S.J. Korsmeyer. 1991. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell. 67: 879-888.
34. Itoh, N., Y. Tsujimoto, and S. Nagata. 1993. Effect of bcl-2 on Fas antigen-mediated cell death. J. Immunol. 151: 621-627.
35. Sidman, C.L., J.D. Marshall, and H. von Boehmer. 1992. Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of Ipr and gld mutant mice. Eur. J. Immunol. 22: 499-504.
36. Owen-Schaub, L.B., S. Yonehara, W.L. Crump III, and E.A. Grimm. 1992. DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell. Immunol. 140: 197-205.
37. Klas, C., K.-M. Debatin, R.R. Jonker, and P.H. Krammer. 1993. Activation interferes with the APO-1 pathway in mature human T cells. Int. Immunol. 5: 625-630.
38. Korsmeyer, S.J. 1992. Bcl-2 initiates a new category of on cogenes: regulators of cell death. Blood. 80: 879-886.
39. Veis, D.J., C.L. Sentman, E.A. Bach, and S.J. Korsmeyer. 1993. Expression of the bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol. 151: 2546-2554.
40. Boise, L.H., M. Gonzalez-Garcia, C.E. Postema, L. Ding, T. Lindsten, L.A. Turka, X. Mao, G. Nunez, and C.B. Thompson. 1993. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell. 74: 597-608.
41. Oltvai, Z.O., C.L. Milliman, and S.J. Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74: 609-619.
42. Alderson, M.R., R.J. Armitage, E. Maraskovsky, TW. Tough, E. Roux, K. Schooley, F. Ramsdell, and D.H. Lynch. 1993. Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 178: 2231-2235.