Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

Nature Medicine

Volumn 1, Issue 2, 1995, Pages 129-134

  Finkel, T H ^a,b   Tudor Williams, G ^c   Banda, N K ^a   Cotton, M F ^b   Curiel, T ^b   Monks, C ^a,b   Baba, T W ^d,e   Ruprecht, R M ^d   Kupfer, A ^a,b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; CD4 ANTIGEN; CD8 ANTIGEN; CYTIDINE DERIVATIVE; DIDANOSINE; GLYCOPROTEIN GP 120; NEVIRAPINE; VIRUS RNA; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL MODEL; APOPTOSIS; ARTICLE; CASE REPORT; CHILD; CONTROLLED STUDY; DRUG TARGETING; ETIOLOGY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IN SITU HYBRIDIZATION; LYMPH NODE BIOPSY; LYMPHADENITIS; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE ACTIVATION; VIRUS REPLICATION;

ANIMAL; APOPTOSIS; CHILD; CHILD, PRESCHOOL; FEMALE; HIV INFECTIONS; HIV-1; HUMAN; LYMPH NODES; MACACA; MALE; RNA, MESSENGER; RNA, VIRAL; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIV; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES;

EID: 0028912254     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm0295-129     Document Type: Article

References (34)

1. Levy, J. A. Pathogenesis of human immunodeficiency virus infection. Microbiol. Rev. 57, 183-289 (1993).
2. Greene, W. C. AIDS and the immune system. Scient. Am. 269, 98-105 (1993).
3. Finkel, T. H. & Banda, N, K, Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells? Cun. Opin. Immun. 6, 605-615 (1994).
4. Terai, C., Kornbluth, R. S., Pavia, D., Richman, D. D. & Carson, D. A. Apop- tosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J. din. Invest. 87, 1710-1715 (1991).
5. Laurent-Crawford, A. et al. The cytopathic effect of HIV is associated with apoptosis. Virology 185, 829-839 (1991).
6. Cohen, J. J. Apoptosis: The physiologic pathway of cell death. Hosp. Pract. 28, 35-43 (1993).
7. Groux, H, Monte, D., Bourrez, J. M., Capron, A. & Ameisen, J. C. Activation-induced death by apoptosis in CD4 T cells from human immunodeficiency virus-infected asymptomatic individuals. J. exp. Med. 175, 331-340 (1992).
8. Meyaard, L. et al. Programmed death of T cells in HIV-1 infection. Science 257, 217-219 (1992).
9. Lewis, D. E., Ng Tang, D. S., Adu-Oppong, A., Schober, W. & Rodgers, J. R. Anergy and apoptosis in CD8+ T cells from HIV-infected persons. J. Immun. 153, 412-420 (1994).
10. Oyaizu, N. et al. Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood 82, 3075-3080 (1993).
11. Gougeon, M. et al. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res. Hum. Retrovir. 9, 553-563 (1993).
12. Pantaleo, G. et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362, 355-358 (1993).
13. Embretson, J. et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362, 359-362 (1993).
14. Gorczyka, W., Bruno, S., Darzynkiewicz, R. J., Gong, J. & Darzynkiewicz, Z. DNA strand breaks during apoptosis. Their early in situ detection by terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int. J. One. 1, 639-648 (1992).
15. Baba, T. W. et al. Mucosal infection of neonatal rhesus monkeys with cell-free SIV. AIDS Res. Hum. Retrovir. 10, 351-357 (1994).
16. Goebel, W. S., Hommel-Berrey, G. & Brahmi, Z. Lymphokine-activated killer cells do not induce degradation of viral or cellular RNA in targets in which DNA fragmentation occurs. FASEB J. 6, A1335 (1992).
17. Liu, Y.-J., Johnson, G. D., Gordon, J. & MacLennan I. C. M. Germinal centres in T-cell-dependent antibody responses. Immun. Today 13, 17-21 (1992).
18. Kuby, J. Immunology (Freeman, New York, 1994).
19. Stein, H., Gerdes, J. & Mason, D. Y. The normal and malignant germinal centre. Clin. Haematol. 11, 531-559 (1982).
20. Gray, D., Kosco, M. & Stockinger, B. Novel pathways of antigen presentation for the maintenance of memory. Int. Immun. 3, 141-148 (1991).
21. Cameron, P. U. et al. Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science 257, 383-387 (1992).
22. Piatak, M. et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259, 1749-1754 (1993).
23. Patterson, B. K. et al. Detection of HIV-1 DNA and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry. Science 260, 976-979 (1993).
24. Stevenson, M., Meier, C., Mann, A. M., Chapman, N. & Wasiak, W. Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: Mechanism for persistence in AIDS. Cell 53, 483-496 (1988).
25. Kowalski, M., Bergeron, L., Dorfman, T., Haseltine, W. & Sodroski, J. Attenuation of human immunodeficiency virus type 1 cytopathic effect by a mutation affecting the transmembrane envelope glycoprotein. J. Virol. 65, 281-291 (1991).
26. Schwartz, L. M. & Osborne, B. A. Programmed cell death, apoptosis and killer genes. Immun. Today 14, 582-590 (1993).
27. Mosier, D. E., Gulizia, R. J., Maclsaad, P. D., Torbett, B. E. & Levy, J. A. Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates. Science 260, 689-692 (1993).
28. Bonyhadi, M. L. et al. HIV induces thymus depletion in vivo. Nature 363, 728-732 (1993).
29. Aldrovandi, G. M. et al. The SCID-Hu mouse as a model for HIV-1 infection. Nature 363, 732-736 (1993).
30. Banda, N. K. et al. Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J. exp. Med. 176, 1099-1106 (1992).
31. Weinhold, K. J. et al. HIV-1 gp120-mediated immune suppression and lymphocyte destruction in the absence of viral infection. J. Immun. 142, 3091-3097 (1989).
32. Siliciano, R. F. et al. Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion. Cell 54, 561-575 (1988).
33. Lyerly, H. K., Matthews, T. J., Langlois, A. J., Bolognesi, D. P. & Weinhold, K. J. Human T-cell lymphotropic virus IIIB glycoprotein (gp120) bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack. Proc. natn. Acad. Sci. U.S.A. 84, 4601-4605 (1987).
34. Fox, C. H. & Cottler-Fox, M. in Cun. Prot in Immun. (eds Coligan, J. E., Kruisbeek, A. M., Margulies, D. H., Shevach, E. M. & Strober, W.) 12.8.1-12.8.21 (Green and Wiley, 1994).