Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet

Pediatric Research

Volumn 37, Issue 5, 1995, Pages 667-670

  Thoresen, Marianne ^e   Penrice, Juliet ^a   Lorek, Ann ^a   Cady, E B ^c   Wylezinska, Marzena ^c   Kirkbride, V ^a   Cooper, C E ^a   Brown, G C ^b   Edwards, A D ^d   Wyatt, J S ^a   Reynolds, E O ^a  

^a Great Ormond Street Hospital for Children   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE PHOSPHATE; PHOSPHATE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN OXYGEN CONSUMPTION; CONTROLLED STUDY; ENERGY EXPENDITURE; INDUCED HYPOTHERMIA; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PERINATAL ASPHYXIA; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SWINE;

ACUTE DISEASE; ANIMAL; ANIMALS, NEWBORN; CEREBRAL CORTEX; ENERGY METABOLISM; HYPOTHERMIA, INDUCED; HYPOXIA, BRAIN; ISCHEMIC ATTACK, TRANSIENT; PHOSPHATES; PHOSPHOCREATINE; SUPPORT, NON-U.S. GOV'T; SWINE;

EID: 0028910724     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/00006450-199505000-00019     Document Type: Article

References (14)

1. Roth SC, Edwards AD, Cady EB, Delpy DT, Wyatt JS, Azzopardi D, Baudin J, Townsend J, Stewart AL, Reynolds EOR 1992 Relation between cerebral oxidative metabolism following birth asphyxia and neurodevelopmental outcome and brain growth at one year. Dev Med Child Neurol 34:285-295
2. Mehmet H, Yue X, Squier MV, Lorek A, Cady EB, Penrice J, Sarraf C, Wylezinska M, Kirkbride V, Cooper C, Brown GC, Wyatt JS, Reynolds EOR, Edwards AD 1994 Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischemia is related to the degree of high energy phosphate depletion during the insult. Neurosci Lett 181:121-125
3. Ginsberg MD, Sternau LL, Globus MY-T, Dietrich WD, Busto R 1992 Therapeutic modulation of brain temperature: relevance to ischemic brain injury. Cerebrovasc Brain Metab Rev 4:189-225
4. Dietrich WD, Busto R, Alonso O, Globus MY-T, Ginsberg MD 1993 Intraischemic but not postischemic brain hypothermia protects chronically following global fore-brain ischemia in rats. J Cereb Blood Flow Metab 13:541-549
5. Carroll M, Beek O 1992 Protection against hippocampal CA1 cell loss by postischemic hypothermia is dependent on delay of initiation and duration. Metab Brain Dis 7:45-50
6. Coimbra C, Wieloch T1994 Moderate hypothermia mitigates neuronal damage in the rat brain when initiated several hours following transient cerebral ischemia. Acta Neuropathol 87:325-331
7. Yager J, Towfighi J, Vannucci RC 1993 Influence of mild hypothermia on hypoxic-ischemic brain damage in the immature rat. Pediatr Res 34:525-529
8. Lorek A, Takei Y, Cady EB, Wyatt JS, Penrice J, Edwards AD, Peebles D, Wylezinska M, Owen-Reece H, Kirkbride V, Cooper CE, Aldridge RF, Roth S, Brown G, Delpy DT, Reynolds EOR 1994 Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorous magnetic resonance spectroscopy. Pediatr Res 36:699-706
9. Westin B, Nyberg R, Miller JA, Wedenberg E 1962 Hypothermia and transfusion with oxygenated blood in the treatment of asphyxia neonatorum. Acta Paediatr Scand (suppl 51):139:1-80
10. Silverman WA, Fertig JW, Berger AP 1958 The influence of the thermal environment upon the survival of newly born premature infants. Pediatrics 22:876-886
11. Zhang RL, Chopp M, Chen H, Garcia JH, Zhang ZG 1993 Postischemic (1 hour) hypothermia significantly reduces ischemic cell damage in rats subjected to 2 hours of middle cerebral artery occlusion. Stroke 24:1235-1240
12. Busto R, Dietrich WD, Globus MY-T, Ginsberg MD 1989 Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury. Neurosci Lett 101:299-304
13. BSgenholm R, Loberg EM, Apricena F, Kjellmer I, Thoresen M 1994 Posfhypoxic hypothermia provides cerebral protection against hypoxic-ischemic brain damage in the neonatal rat. Proceedings of the 14th European Congress of Perinatal Medicine, Helsinki, Finland: Kirjapaino Tapo Oy, 250
14. Blumberg RM, Sirimanne ES, Williams CE, Edwards AD, Gluckman PD 1994 Effect of delayed hypothermia on hypoxic-ischaemic cerebral injury in the developing rat. Proceedings of the 14th European Congress of Perinatal Medicine, Helsinki, Finland: Kirjapaino Tapo Oy, 249