Intermediate steps in positive selection: Differentiation of CD4+8int TCRint thymocytes into CD4−8+TCRhi Thymocytes

Journal of Experimental Medicine

Volumn 181, Issue 5, 1995, Pages 1643-1651

  Lundberg, Katarina ^a   Heath, William ^a   Köntgen, Frank ^a   Carbone, Francis R ^b   Shortman, Ken ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY MEDICAL SCHOOL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; LYMPHOCYTE DIFFERENTIATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; THYMUS;

ANIMAL; ANTIGENS, CD4; ANTIGENS, CD8; CELL DIFFERENTIATION; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES;

EID: 0028906216     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.181.5.1643     Document Type: Article

References (34)

1. Davies, M.M., and P.J. Bjorkman. 1988. Tcell antigen receptor genes and T-cell recognition. Nature (Lond.). 334: 395-402.
2. Miceli, M.C., andJ.R. Parnes. 1993. Role of CD4 and CD8 in T cell activation and differentiation. Adv. Immunol 53: 59-122.
3. Benoist, C., and D. Mathis. 1992. Generation of the ceβ T-cell repertoire. Curr. Opin. Immunol. 4: 156-161.
4. Robey, E., and B.J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12: 675-705.
5. von Boehmer, H., W. Swat, and P. Kisielow. 1993. Positive selection of immature α/β T cells. Immunol. Rev. 135: 67-79.
6. Borgulya, P., H. Kishi, U. Muller, J. Kirberg, and H. von Boehmer. 1991. Development of the CD4 and CD8 lineage of T cells: instruction versus selection. EMBO(Eur. Mol. Biol. Organ.) J. 10: 913-918.
7. Robey, E.A., B.J. Fowlkes, J.W. Gordon, D. Kioussis, H. von Boehmer, F. Ramsdell, and R. Axel. 1991. Thymic selection in CDS transgenic mice supports an instmctive model for commitment to a CD4 or CD8 lineage. Cell. 64: 99-107.
8. Chan, S.H., D. Cosgrove, C. Waltzinger, C. Benoist, and D. Mathis. 1993. Another view of the selective model of thymocyte selection. Cell. 73: 225-236.
9. Davis, C.B., N. Killeen, M.E.C. Crooks, D. Raulet, andD.R. Littman. 1993. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell. 73: 237-247.
10. + thymocytes: selection rather than instruction. Science (Wash. DC). 261: 911-915.
11. Crump, A.L., M.J. Grusby, L.H. Glimcher, and H. Cantor. 1993. Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc. Natl. Acad. Set. USA. 90:10739-10743.
12. Kontgen, F., G. Suss, C. Stewart, M. Steinmetz, and H. Bluethmann. 1993. Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int. Immunol. 5: 957-964.
13. Guidos, C.J., J.S. Danska, C.G. Fathman, andl.L. Weissman. 1990. T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. J. Exp Med. 172: 835-845.
14. +CD8" thymocytes represents an intermediate stage in intrathymic repertoire selection. Int. Immunol. 4: 153-161.
15. Marodon, G., and B. Rocha. 1994. Generation of mature T cell populations in the thymus: CD4 or CD8 down-regulation occurs at different stages of thymocyte differentiation. Eur. J. Immunol. 24: 196-204.
16. Hogquist, K.A., S.C. Jameson, W.R. Heath, J.L. Howard, M.J. Bevan, and F.R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell. 76: 17-27.
17. Wilson, A., A. D’Amico, T. Ewing, R. Scollay, and K. Shortman. 1988. Subpopulations of early thymocytes: a crosscorrelation flow-cytometric analysis of adult mouse Ly 2" L3T4" (CD8-CD4") thymocytes using eight different surface markers. J. Immunol. 140: 1461-1469.
18. Lundberg, K., and K. Shortman. 1994. Small cortical thymocytes are subject to positive selection. J. Exp. Med. 179:1475-1483.
19. Tomonari, K. 1988. A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex. Immunogenetics. 28: 455-458.
20. Scollay, R., J. Smith, and V. Stauffer. 1986. Dynamics of early T cells: prothymocyte migration and proliferation in the adult mouse thymus. Immunol. Rev. 91: 129-157.
21. Houston, L.L., R. Nowinski, and I. Bernstein. 1980. Specific in vivo localization on monoclonal antibodies directed against the Thy 1.1 antigen. J. Immunol. 125: 837-843.
22. Holmes, K.L., W.Y. Langdon, T.N. Fredrickson, R.L. Coffman, P.M. Hoffman, J.W. Hartley, and H.C. Morse. 1986. Analysis of neoplasms induced by CAS-BR-M MULV tumour extracts. J. Immunol. 137: 679-688.
23. Springer, T., G. Galfre, D.S. Secher, and C. Milstein. 1978. Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur. J. Immunol. 8: 539-551.
24. Coffman, R.L. 1982. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69: 5-23.
25. Bhattacharya, A., M.E. Dorf, and T.A. Springer. 1981. A shared alloantigenic determinant on la antigens encoded by the IA and IE subregions: evidence of I region gene duplication. J. Immunol. 127: 2488-2495.
26. Ledbetter, J.A., and L.A. Herzenberg. 1979. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47: 63-90.
27. Hugo, P., and H.T. Petrie. 1992. Multiple routes for late intrathymic precursors to generate CD4+CD8+ thymocytes. Adv. Mol. Cell. Biol. 5: 37-53.
28. Petrie, H.T., A. Strasser, A.W. Harris, P. Hugo, and K. Shortman. 1993. CD4+8" and CD4"8+ mature thymocytes require different post-selection processing for final development. J. Immunol. 151: 1273-1279.
29. Shortman, K., D. Vremec, and M. Egerton. 1991. The kinetics of T cell antigen receptor expression by subgroups of CD4 + 8+ thymocytes: delineation of CD4+8+32+ thymocytes as post-selection intermediates leading to mature T cells. J. Exp Med. 173: 323-332.
30. Borgulya, P., H. Kishi, U. Muller, J. Kirberg, and H. von Boehmer. 1991. Development of the CD4 and CD8 lineage of T cells: instruction versus selection. EMBO (Eur. Mol. Biol. Organ.) J. 10: 913-918.
31. Robey, E., A. Itano, W.C. Fanslow, and BJ. Fowlkes. 1994. Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice. J. Exp Med. 179: 1997-2004.
32. + cells in β2-microglobulin-deficient mice. Eur. J. Immunol. 24: 1933-1936.
33. + thymocytes selected by MHC class I molecules. Science (Wash. DC). 263: 1774-1778.
34. + single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp Med. 180: 25-34.