Characterization of a Class of Peptide Boronates with Neutral P1 Side Chains as Highly Selective Inhibitors of Thrombin

Journal of Medicinal Chemistry

Volumn 38, Issue 9, 1995, Pages 1511-1522

  Deadman, John J ^a   Elgendy, Said ^a   Goodwin, Christopher A ^a   Green, Donovan ^a   Baban, Jehan A ^a   Patel, Geeta ^a   Skordalakes, Emmanuel ^a   Claeson, Goran ^a   Kakkar, Vijay V ^a   Scully, Michael F ^a  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BLOOD CLOTTING FACTOR 10A; BORONIC ACID DERIVATIVE; CATHEPSIN G; CHYMOTRYPSIN; ELASTASE; KALLIKREIN; PEPTIDE DERIVATIVE; PLASMIN; SERINE PROTEINASE; THROMBIN; THROMBIN INHIBITOR; TRIPEPTIDE; UROKINASE;

ANTICOAGULATION; ARTICLE; COMPETITIVE INHIBITION; DRUG BINDING; DRUG POTENCY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; PARTIAL THROMBOPLASTIN TIME; THROMBIN TIME;

BORONIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 0028905557     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00009a012     Document Type: Article

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