CD28-B7 blockade after alloantigenic challenge in vivo inhibits thl cytokines but spares Th2

Journal of Experimental Medicine

Volumn 181, Issue 5, 1995, Pages 1869-1874

  Sayegh, Mohamed H ^a   Akalin, Enver ^a   Hancock, Wayne W ^b   Russell, Mary E ^c   Carpenter, Charles B ^a   Linsley, Peter S ^d   Turka, Laurence A ^e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; B7 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; HYBRID PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; INTERLEUKIN 10; INTERLEUKIN 2; RECOMBINANT INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR;

ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; GRAFT SURVIVAL; HELPER CELL; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE SUBPOPULATION; VASCULITIS;

ANIMAL; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; CYTOKINES; IMMUNE TOLERANCE; INTERLEUKIN-2; ISOANTIGENS; KIDNEY TRANSPLANTATION; MALE; RATS; RATS, INBRED BN; RATS, INBRED LEW; SUPPORT, U.S. GOV'T, P.H.S.; TH1 CELLS; TH2 CELLS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0028903939     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.181.5.1869     Document Type: Article

References (22)

1. Schwartz, R.H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell. 71: 1065-1068.
2. Linsley, P.S., and J.A. Ledbetter. 1993. The role of the CD28 receptor during T cell responses to antigen. Antiu. Rev. Immunol. 11: 191-212.
3. Turka, L.A., P.S. Linsley, H. Lin, W. Brady, J.M. Leiden, R.Q. Wei, M.L. Gibson, X.G. Zheng, S. Myrdal, D. Gordon, et al. 1992. T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo. Proc Natl. Acad. Sci. USA. 89: 11102-11105.
4. Tan, P., C. Anasetti, J.A. Hansen, J. Melrose, M. Brunvand, J. Bradshaw, J.A. Ledbetter, and P.S. Linsley. 1993. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 177: 165-173.
5. Linsley, P.S., P.M. Wallace, J. Johnson, M.G. Gibson, J.L. Greene, J.A. Ledbetter, C. Singh, and M.A. Tepper. 1992. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science (Wash. DC). 257: 792-795.
6. Lenschow, D.J., Y. Zeng, R. Thistlethwaite, A. Montag, W. Brady, M.G. Gibson, P.S. Linsley, and J.A. Bluestone. 1992. Long-term survival of Xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science (Wash. DC). 257: 789-792.
7. Lin, H., S.F. Bolling, P.S. Linsley, R.Q. Wei, D. Gordon, C.B. Thompson, and L.A. Turka. 1993. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J. Exp Med. 178: 1801-1806.
8. Pearson, T.C., D.Z. Alexander, K.J. Winn, P.S. Linsley, R.P. Lowry, and C.P. Larsen. 1994. Transplantation tolerance induced by CTLA4-Ig. Transplantation. 57: 1701-1706.
9. Sayegh, M.H., N. Perico, L. Gallon, O. Imberti, W.W. Hancock, G. Remuzzi, and C.B. Carpenter. 1994. Mechanisms of acquired thymic unresponsiveness to renal allografts: thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy. Transplantation. 58: 125-132.
10. Khoury, S.J., W.W. Hancock, and H.L. Weiner. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential up-regulation of transforming growth factor-β and prostaglandin E expression in the brain. J. Exp Med. 176: 1355-1364.
11. Khoury, S.J., M.H. Sayegh, L. Gallon, W.W. Hancock, C.B. Carpenter, and H.L. Weiner. 1993. Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalotigenic peptide. J. Exp Med. 178: 559-566.
12. Hancock, W.W., S.J. Khoury, C.B. Carpenter, and M.H. Sayegh. 1994. Differential effects of oral versus intrathymic administration of polymorphic MHC class II peptides on mononuclear and endothelial cell activation and cytokine expression during a delayed-type hypersensitivity response. Am. J. Pathol. 144: 1149-1158.
13. Austyn, J.M., D.F. Hankins, C.P. Larsen, P.J. Morris, A.S. Rao, and J.A. Roake. 1994. Isolation and characterization of dendritic cells from mouse heart and kidney. J. Immunol. 152: 2401-2410.
14. Mosmann, T.R., and R.L. Coffman. 1989. Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv. Immunol. 46: 111-147.
15. Kupiec-Weglinski, J.W., B. Wasowska, I. Papp, G. Schmidbauer, M.H. Sayegh, W.M.I. Baldwin, K.J. Wieder, and W.W. Hancock. 1993. CD4mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition ofThl lymphokines. J. Immunol. 151: 5053-5061.
16. Takeuchi, T., R.P. Lowry, and B. Konieczny. 1992. Heart allografts in murine systems. The differential activation of Th2-like effector cells in peripheral tolerance. Transplantation. 53: 1281-1294.
17. Snijdewint, E.G.M., P. Kalinsky, E.A. Wierenga, J.D. Bos, and M.L. Kapsenberg. 1993. Prostaglandin-E(2) differentially modulates cytokine secretion profiles of human T-helper lymphocytes. J. Immunol. 150: 5321-5329.
18. Boussiotis, V.A., G.J. Freeman, J.G. Gribben, J. Daley, G. Gray, and L.M. Nadler. 1993. Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T cell activation. Proc. Natl. Acad. Sci. USA. 90: 11059-11063.
19. McArthur, J.G., and D.H. Raulet. 1993. CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin. J.Exp Med. 178: 1645-1653.
20. Seder, R.A., R.N. Germain, P.S. Linsley, and W.E. Paul. 1994. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. J. Exp. Med. 179: 299-304.
21. Lu, P., X. Zhou, S.J. Chen, M. Moorman, S.C. Morris, F.D. Pinkelman, P.S. Linsley, J.F. Urban, and W.C. Gause. 1994. CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite. J. Exp Med. 180: 693-698.
22. Croft, M., and S. S.L. 1991. B cell response to T helper cell subsets. II. Both the stage of T cell response and the cytokine secreted determine the extent and nature of helper activity. J. Immunol. 147: 3679-3689.