Novel Antiasthmatic Agents with Dual Activities of Thromboxane A2 Synthetase Inhibition and Bronchodilation. VI.1) Indazole Derivatives

Chemical and Pharmaceutical Bulletin

Volumn 43, Issue 2, 1995, Pages 332-334

  Yamaguchi, Masahisa ^a   Maruyama, Noriaki ^a   Koga, Takaki ^a   Kamel, Kenshi ^a   Akima, Michitaka ^a   Kuroki, Toshio ^a   Hamana, Masatomo ^a   Ohi, Nobuhiro ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

antiasthematic agent; bronchodilator; indazole derivative; TXA2 synthetase inhibitor

Indexed keywords

2 ETHYL 4 (3 PYRIDYL) 1(2H) PHTHALAZINONE; 3 ETHOXY 1 (3 PYRIDYL) 1H INDAZOLE; AMINOPHYLLINE; ANTIASTHMATIC AGENT; INDAZOLE DERIVATIVE; OZAGREL; THROMBOXANE B2; THROMBOXANE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG SYNTHESIS; ENZYME INHIBITION; GUINEA PIG; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION; TRACHEA;

ADMINISTRATION, ORAL; AMINOPHYLLINE; ANIMAL; BENZOFURANS; BRONCHODILATOR AGENTS; COMPARATIVE STUDY; FATTY ACIDS, MONOUNSATURATED; GUINEA PIGS; HISTAMINE ANTAGONISTS; IN VITRO; INDAZOLES; MALE; METHACRYLATES; PENTANOIC ACIDS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOXANE-A SYNTHASE; TRACHEA;

EID: 0028903272     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.43.332     Document Type: Article

References (11)

1. M. Yamaguchi, N. Maruyama, T. Koga, K. Kamei, M. Akima, T. Kuroki, M. Hamana, N. Ohi, Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation V. Thienopyridazinone derivatives. Chem. Pharm. Bull., 43, 236 (1994).
2. M. Yamaguchi, K. Kamei, T. Koga, M. Akima, T. Kuroki, N. Ohi, J. Med. Chem., 36, 4052 (1993)
3. M. Yamaguchi, K. Kamei, T. Koga, M. Akima, N. Maruyama, T. Kuroki, N. Ohi, J. Med. Chem., 36, 4061 (1993)
4. M. Yamaguchi, T. Koga, K. Kamei, M. Akima, T. Kuroki, M. Hamana, N. Ohi, Chem. Pharm. Bull., 42, 1601 (1994)
5. M. Yamaguchi, T. Koga, K. Kamei, M. Akima, N. Maruyama, T. Kuroki, M. Hamana, N. Ohi, Chem. Pharm. Bull., 42, 1850 (1994).
6. K. Kato, S. Ohkawa, S. Terao, Z. Terashita, K. Nishikawa, J. Med. Chem., 28, 287 (1985).
7. F. De Clerck, J. Beetens, D. de Chaffoy de Courcelles, E. Freyne, P.A.J. Janssen, Thromb. Haemost., 61, 35 (1989).
8. K. Iizuka, K. Akahane, D. Momose, M. Nakazawa, T. Tanouchi, M. Kawamura, I. Ohyama, I. Kajiwara, Y. Iguchi, T. Okada, K. Taniguchi, T. Miyamoto, M. Hayashi, J. Med. Chem., 24, 1139 (1981).
9. J.L. Mehta, D.L. Lawson, W.W. Nichols, Am. J. Physiol., 257, 1240 (1989).
10. V.A. Petrow, J. Chem. Soc., 1978, 927.
11. L. Baiocchi, G. Corsi, G. Palazzo, Synthesis, 1978, 633.