Wnt5a Cloning, Expression, and Up-Regulation in Human Primary Breast Cancers

Clinical Cancer Research

Volumn 1, Issue 2, 1995, Pages 215-222

  Lejeune, Sue ^a   Huguet, Emmanuel L ^a   Hamby, Andrew ^a   Poulsom, Richard ^a   Harris, Adrian L ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; MOLECULAR CLONING; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; BRAIN; BREAST; BREAST NEOPLASMS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 3; CLONING, MOLECULAR; CONSERVED SEQUENCE; FEMALE; FETUS; GENE LIBRARY; HUMAN; IN SITU HYBRIDIZATION; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PLACENTA; PREGNANCY; PROTEINS; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED; XENOPUS;

EID: 0028902359     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Nusse, R., vanOoyen, A., Cox, D., Fung, Y. K., and Varmus, H. Mode of proviral activation of a putative mammary oncogene (int-l) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumour virus. Mol. Cell. Biol., 10: 4170–4179, 1984.
2. Rijsewijk, F., Schuermann, M., Wagenaar, E., Parren, P., Weigel, D., and Nusse, R. The Drosophila homolog of the mouse mammary oncogene int-l is identical to the segment polarity gene wingless. Cell, 50: 649–657, 1987.
3. Roelink, H., Wagenaar, E., Lopes, D.S.S., and Nusse, R. Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-l/Wnt-1 and is normally expressed in mouse embryos and adult brain. Proc. Natl. Acad. Sci. USA, 87: 4519–4523, 1990.
4. Roelink, H., Wagenaar, E., and Nusse, R. Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors. Oncogene, 7: 487–492, 1992.
5. Gavin, B. J., McMahon, J. A., and McMahon, A. P. Expression of multiple novel Wnt-l/int-/-related genes during fetal and adult mouse development. Genes Dev., 4: 2319–2332, 1990.
6. Papkoff, J., Brown, A. M., and Varmus, H. E. The int-l protooncogene products are glycoproteins that appear to enter the secretory pathway. Mol. Cell. Biol. 7: 3978–3984, 1987.
7. Smolich, B. D., McMahon, J. A., McMahon, A. P., and Papkoff, J. Wnt family proteins are secreted and associated with the cell surface. Mol. Biol. Cell, 4: 1267–1275, 1993.
8. Blasband, A., Schryver, B., and Papkoff, J. The biochemical properties and transforming potential of human Wnt-2 are similar to Wnt-1. Oncogene, 7: 153–161, 1992.
9. Jue, S. F., Bradley, R. S., Rudnicki, J. A., Varmus, H. E., and Brown, A. M. The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Mol. Cell. Biol., 12: 321–328, 1992.
10. Gavin, B. J., and McMahon, A. P. Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol. Cell. Biol., 12: 2418–2423, 1992.
11. Buhler, T. A., Dale, T. C., Kieback, C., Humphreys, R. C., and Rosen, J. M. Localization and quantification of Wnt-2 gene expression in mouse mammary development. Dev. Biol., 155: 87–96, 1993.
12. Huguet, E. L., McMahon, J. A., McMahon, A. P., Bicknell, R., and Harris, A. L. Differential expression of human Wnt genes 2, 3, 4, and 7b in human breast cell lines and normal and diseased states of human breast tissue. Cancer Research, 54: 2615–2621, 1994.
13. Olson, D. J., and Moon, R. T. Distinct effects of ectopic expression of Wnt-1, activin B, and bFGF on gap junctional permeability in 32-cell Xenopus embryos. Dev. Biol., 151: 204–212, 1992.
14. Moon, R. T., Campbell, R. M., Christian, J. L., McGrew, L. L., Shih, J., and Fraser, S. Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis. Development, 119: 97–111, 1993.
15. Southern, E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol., 98: 503–517, 1975.
16. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. Current Protocols in Molecular Biology, Vol. 1, pp. 4.7.1–4.7.8. New York: Green Publishing Associates and Wiley Interscience, 1991.
17. Chomczinski, P., and Sacchi, N. Single step isolation of RNA by acid guanidium thiocyanate-phenol-chloroform extraction. Ann. Biochem., 162: 321–328, 1987.
18. McCarthy, S., and Bicknell, R. Responses of pertussis toxin treated microvascular endothelial cells to transforming growth factor p. J. Biol. Chem., 267: 21617–21622, 1992.
19. Lejeune, S., Leek, R., Horak, E., Plowman, G., Greenall, M., and Harris, A. L. Amphiregulin, EGF receptor, and estrogen receptor in human breast cancer. Cancer Res. 53: 3597–3602, 1993.
20. Senior, P. V., Critchley, D. R., Beck, F., Walker, F. A., and Varley, J. M. The localization of lamini mRNA and protein in the postimplantation embryo and placenta of the mouse: an in situ hybridisation and immunocytochemical study. Development, 104: 431–446, 1988.
21. Wright, N. A., Poulsom, R., and Stamp, G. W. Epidermal growth factor receptor induces expression of regulatory peptides in damaged human gastrointestinal tissue. J. Pathol., 162: 279–284, 1990.
22. Fox, S. B., Smith, K., Hollyer, J., Greenall, M., Hastrich, D., and Harris, A. L. The epidermal growth factor receptor as a prognostic marker: results of 370 patients and review of 3009 patients. Breast Cancer Res. Treat., 29: 41–49, 1994.
23. Gavin, B. J., McMahon, J. A., and McMahon, A. P. Expression of multiple novel Wnt-1/int-/-related genes during fetal and adult mouse development. Genes Dev., 4: 2319–2332, 1990.
24. Christian, J. L., Gavin, B. J., McMahon, A. P., and Moon, R. T. Isolation of cDNAs partially encoding four Xenopus Wnt-l/int-l-related proteins and characterization of their transient expression during embryonic development. Dev. Biol., 143: 230–234, 1991.
25. Sidow, A. Diversification of the Wnt gene family on the ancestral lineage of vertebrates. Proc. Natl. Acad. Sci. USA, 89: 5098–5102, 1992.
26. Mastro, R., Gasparotto, D., Vukosavljevic, T., Barzan, L., Sulfaro, S., and Boiocchi, M. Three discrete regions of deletion at 3p in head and neck cancers. Cancer Res., 53: 5775–5779, 1993.
27. Callahan, R., Cropp, C., Merlo, G., Campbell, G., and Lidereau, R. Mutations in breast cancer. In: The Therapeutic Implications of the Molecular Biology of Breast Cancer, pp. 57–67. Rome: John Libbey CIC, 1991.
28. Clark, C. C., Cohen, I., Eichstetter, I., Cannizzaro, L. A., McPherson, J. D., Wasmuth, J. J., and Iozzo, R. V. Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3pl4-p21. Genomics, 18: 249–260, 1993.
29. Lin, T. P., Guzman, R. C., Osborn, R. C., Thordarson, G., and Nandi, S. Role of endocrine, autocrine, and paracrine interactions in the development of mammary hyperplasia in Wnt-1 transgenic mice. Cancer Res., 52: 4413–4419, 1992.
30. Olson, D., and Papkoff, J. Regulated expression of Wnt family members during proliferation of C57mg mammary cells. Cell Growth & Differ., 5: 197–206, 1994.