Altered representation of naive and memory CD8 T cell subsets in HIV-infected children

Journal of Clinical Investigation

Volumn 95, Issue 5, 1995, Pages 2054-2060

  Rabin, Ronald L ^a,d   Roederer, Mario ^a   Maldonado, Yvonne ^a   Petru, Ann ^b   Herzenberg, Leonard A ^a,c   Herzenberg, Leonore A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OAKLAND   (United States)

^c STANFORD UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Acquired immunodeficiency syndrome; Naive T cells; T cell subsets; T4 cells; T8 cells

Indexed keywords

ANTIVIRUS AGENT; CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; DIDANOSINE; L SELECTIN; LEUKOCYTE ANTIGEN; LEVOTHYROXINE SODIUM; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; RECOMBINANT GROWTH HORMONE; SOMATREM; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; ARTICLE; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CONGENITAL HYPOTHYROIDISM; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GROWTH HORMONE DEFICIENCY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; LYMPHOCYTE COUNT; MALE; MEMORY CELL; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ACTINS; ADOLESCENT; ANTIGENS, CD; BASE SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; COMPARATIVE STUDY; DNA PRIMERS; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HIV INFECTIONS; HIV SERONEGATIVITY; HUMAN; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INFANT; INTERFERON TYPE II; INTERLEUKINS; LYMPHOCYTE COUNT; MALE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTE SUBSETS;

EID: 0028902027     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117891     Document Type: Article

References (30)

1. + cell anti-HIV activity: nonlytic suppression of virus replication. AIDS Res. Hum. Retroviruses. 8:1039-1050.
2. + cells defined by anti-CD45RA (2H4) and anti-CD29 (4B4) antibodies. Cell. Immunol. 128:314-328.
3. + cells with different requirements for activation and differentiation. J. Immunol. 146:2088-2094.
4. Clement, L. T. 1992. Isoforms of the CD45 common leukocyte antigen family: markers for human T-cell differentiation. J. Clin. Immunol. 12:1-10.
5. McGrath, M. S. 1990. T cell abnormalities. In AIDS Knowledge Base. Textbook on HIV from the University of California, San Francisco and San Francisco General Hospital. P. T. Cohen, M. A. Sande, and P. A. Volberding, editors. Medical Publishing Group, Waltham. 3.2.2-1-3.
6. Steihm, E. R., and D. W. Wara. 1991. Immunology of HIV. In Pediatric AIDS: The challenge of HIV infection in infants, children, and adolescents. P. A. Pizzo and C. M. Wilfert, editors. Williams and Wilkins, Baltimore. 95-112.
7. Prince, H. E., S. Kleinman, C. Czaplicki, J. John, and A. E. Williams. 1990. Interrelationships between serologic markers of immune activation and T lymphocyte subsets in HIV infection. J. Acquired Immune Defic. Syndr. 3:525-530.
8. Giorgi, J. V., and R. Detels. 1989. T-cell subset alterations in HIV-infected homosexual men: NIAlD multicenter AIDS cohort study. Clin. Immunol. Immunopathol. 52:10-18.
9. Teitel, J. M., J. J. Freedman, M. B. Garvey, and M. Kardish. 1989. Two-year evaluation of clinical and laboratory variables of immune function in 117 hemophiliacs seropositive or seronegative for HIV-1. Am. J. Hematol. 32:262-272.
10. Froebel, K. S., K. V. Doherty, J. A. Whitelaw, R. A. Hague, J. Y. Mok, and A. G. Bird. 1991. Increased expression of the CD45RO (memory) antigen on T cells in HIV-infected children. AIDS (Phila.). 5:97-99.
11. Borkowsky, W., T. Moore, K. Krasinski, K. O. Ajuang-Simbiri, and R. Holzman. 1992. Evolution of phenotypic memory T cells in HIV-1 infected infants and children. Clin. Immunol. Immunopathol. 63:280-284.
12. Bell, E. B., and S. M. Sparshott. 1990. Interconversion of CD45R subsets of CD4 T cells in vivo. Nature (Lond.). 348:163-166.
13. + T cell line. J. Immunol. 146:1175-1183.
14. Gray, D. 1993. Immunological memory. Annu. Rev. Immunol. 1993:49-77.
15. Sanders, M. E., M. W. Makgoba, S. O. Sharrow, D. Stephany, T. Springer, H. A. Young, and S. Shaw. 1988. Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CD229, and Pgp-1) and have enhanced IFN-γ production. J. Immunol. 140:1401-1407.
16. Picker, L. J., J. R. Treer, D. B. Ferguson, P. A. Collins, D. Buck, and L. W. Terstappen. 1993. Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition. J. Immunol. 150:1105-1121.
17. Roederer, M., J. G. Dubs, M. T. Anderson, P. A. Raju, L. A. Herzenberg, and L. A. Herzenberg. 1995. CD8 naive T cell counts decrease progressively in HIV-infected adults. J. Clin. Invest. 95:2061-2066.
18. Roederer, M., F. J. T. Staal, M. T. Anderson, R. Rabin, P. A. Raju, L. A. Herzenberg, and L. A. Herzenberg. 1993. Disregulation of leukocyte glutathione in AIDS. In Clinical Flow Cytometry. A. L. Landay, K. A. Ault, K. D. Bauer, and P. S. Rabinovitch, editors. New York Academy of Sciences, New York. 113-125.
19. Moore, W. A., and R. A. Kautz. 1986. Data analysis in flow cytometry. In Handbook of Experimental Immunology. D. M. Weir, L. A. Herzenberg, and L. A. Herzenberg, editors. Blackwell Scientific Publications, Edinburgh. 30.1-30.11.
20. + T cells contain cells with high levels of lymphocyte function-associated antigen-1 expression, a phenotype of primed T cells. J. Immunol. 150:429-437.
21. Byrne, J. A., J. L. Butler, and M. D. Cooper. 1988. Differential activation requirements for virgin and memory T cells. J. Immunol. 141:3249-3257.
22. -) subsets in human immunodeficiency virus infection. J. Clin. Lab. Anal. 5:96-100.
23. Prince, H. E., and E. R. Jensen. 1991. Three-color cytofluorometric analysis of CD8 cell subsets in HIV-1 infection. J. Acquired Immune Defic. Syndr. 4:1227-1232.
24. Froebel, K. S., K. V. Doherty, J. A. Whitelaw, R. A. Hague, J. Y. Mok, and A. G. Bird. 1991. Increased expression of the CD45RO (memory) antigen on T cells in HIV-infected children. AIDS (Phila.). 5:97-99.
25. Church, J. A., G. Costin, and J. Brooks. 1989. Immune functions in children treated with biosynthetic growth hormone. J. Pediatr. 115:420-423.
26. high T cell population. Eur. J. Immunol. 23:1057-1063.
27. Bonyhadi, M. L., L. Rabin, S. Salimi, D. Brown, J. Kosek, J. McCune, and H. Kaneshima. 1993. HIV induces thymus depletion in vivo. Nature (Lond.). 363:728-732.
28. Smerdon, R. A., M. Peakman, M. J. Hussain, L. Alviggin, P. J. Watkins, R. D. Leslie, and D. Vergani. 1993. Increase in simultaneous coexpression of naive and memory lymphocyte markers at diagnosis of IDDM. Diabetes. 42:127-133.
29. Semba, R. D., Muhilal, B. J. Ward, D. E. Griffin, A. L. Scott, G. Natadisastra, K. J. West, and A. Sommer. 1993. Abnormal T-cell subset proportions in vitamin-A-deficient children. Lancet. 341:5-8.
30. Cook, R. T., T. J. Waldschmidt, Z. K. Ballas, B. L. Cook, B. M. Booth, B. C. Steward, and M. J. Garvey. 1994. Fine T-cell subsets in alcoholics as determined by the expression of L-selectin, leukocyte common antigen, and β-integrin. Alcohol Clin. Exp. Res. 18:71-80.