Reconstitution of protein kinase A regulation of the rat prolactin promoter in HeLa nonpituitary cells: Identification of both GHF-1/Pit-1-dependent and -independent mechanisms

Molecular Endocrinology

Volumn 9, Issue 4, 1995, Pages 502-512

  Rajnarayan, Sudha ^a   Chiono, Matt ^a   Alexander, Linda M ^a,b   Gutierrez Hartmann, Arthur ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b University of Colorado Health Science Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; BETA GLOBIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; FORSKOLIN; LUCIFERASE; PROLACTIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL STRAIN GH3; CONTROLLED STUDY; DNA FOOTPRINTING; DNA TRANSFECTION; ENZYME ACTIVE SITE; ENZYME RECONSTITUTION; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE; SITE DIRECTED MUTAGENESIS;

ANIMAL; BASE SEQUENCE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HELA CELLS; HUMAN; MOLECULAR SEQUENCE DATA; PROLACTIN; PROMOTER REGIONS (GENETICS); RATS; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0028898976     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/mend.9.4.7659093     Document Type: Article

References (46)

1. Voss JW, Rosenfeld MG 1992 Anterior pituitary development: Short tales from dwarf mice. Cell 70: 527-530
2. Tashjian AHJ, Yasumura Y, Levine L, Sato GH, Parker ML 1968 Establishment of clonal strains of rat pituitary tumor cells that secrete growth hormone. Endocrinology 82: 342-352
3. Elsholtz HP 1992 Molecular biology of prolactin: Cell-specific and endocrine regulators of the prolactin gene. Semin Reprod Endocrinol 10: 183-195
4. Maurer RA 1981 Transcriptional regulation of the prolactin gene by ergocryptine and cyclic AMP. Nature 294: 94-97
5. Elsholtz HP, Lew AM, Albert PR, Sundmark VC 1991 Inhibitory control of prolactin and Pit-1 gene promoters by dopamine. J Biol Chem 266: 22919-22925
6. Frohman LA 1987 Diseases of the anterior pituitary. In: Fellg P, Baxter JD, Broadus AE, Frohman LA (eds) Endocrinology and Metabolism, ed 2. McGraw-Hill Book Co, New York, pp 247-337
7. Keech CA, Gutlerrez-Hartmann A 1989 Analysis of rat prolactin promoter sequences that mediate pituitary-specific and 3',5'-cyclic adenosine monophosphate-regulated gene expression in vivo. Mol Endocrinol 3: 832-839
8. Keech CA, Jackson SM, Siddiqui SK, Ocran KW, Guti-errez-Hartmann A 1992 Cyclic AMP activation of the rat prolactin promoter is restricted to the pituitary-specific cell type. Mol Endocrinol 6: 2059-2070
9. Day RN, Walder JA, Maurer RA 1989 A protein kinase inhibitor gene reduces both basal and multihormone-stimulated prolactin gene transcription. J Biol Chem 264: 431-436
10. Iverson RA, Day KH, d’Emden M, Day RN, Maurer RA 1990 Clustered point mutation analysis of the rat prolactin promoter. Mol Endocrinol 4: 1564-1571
11. Conrad KE, Gutlerrez-Hartmann A 1992 The ras and protein kinase A pathways are mutually antagonistic in regulating rat prolactin promoter activity. Oncogene 7: 1279-1286
12. Hoeffler JP, Habener JF 1990 Characterization of a cyclic AMP regulatory element DNA-bindlng protein. Trends Endocrinol Metab 1: 155-158
13. Liang J, Kim KE, Schoderbeck WE, Maurer RA 1992 Characterization of a nontissue-specific, 3',5'-cyclic adenosine monophosphate-responsive element of the proxim al region of the rat prolactin gene. Mol Endocrinol 6: 885-892
14. Peers B, Monget P, Nalda MA, Voz ML, Berwaer M, Belayew A, Martial JA 1991 Transcriptional Induction of the human prolactin gene by cAMP requires two exacting elements and at least the pituitary-specific factor Pit-1. J Biol Chem 266: 18127-18134
15. Yan G-Z, Chen X-H, Bancroft C 1994 A constltutively active form of CREB can activate expression of the rat prolactin promoter in non-pituitary cells. Mol Cell Endocrinol 101: R25-R30
16. Peers B, Nalda AM, Monget P, Voz ML, Belayew A, Martial JA 1992 Binding of a 100-kDa ubiquitous factor to the human prolactin promoter is required for its basal and hormone regulated activity. Eur J Biochem 210: 53-58
17. d’Emden MC, Oklmura Y, Maurer RA 1992 Analysis of functional cooperativity between Individual transcription-stimulating elements in the proximal region of the rat prolactin gene. Mol Endocrinol 6: 581-588
18. Stanley FM 1992 An element in the prolactin promoter mediates the stimulatory effect of insulin on transcription of the prolactin gene. J Biol Chem 267: 16719-16726
19. Jackson SM, Keech CA, Williamson DJ, Gutierrez-Hart-mann A 1992 Interaction of positive and negative transcription elements controls repression of the proximal rat prolactin promoter in nonpituitary cells. Mol Cell Biol 12: 2708-2719
20. Elsholtz HP, Mangalam HJ, Potter E, Albert VR, Supowit S, Evans RM, Rosenfeld MG 1986 Two different cis-active elements transfer the transcriptional effects of both EGF and phorbol esters. Science 234: 1552-1557
21. Schoderbek WE, Kim KE, Ridgway EC, Mellon PL, Maurer RA 1992 Analysis of DNA sequences required for pituitary-specific expression of the glycoprotein hormone a-subunlt gene. Mol Endocrinol 6: 893-903
22. Conrad KE, Oberwetter JM, Vallaincourt R, Johnson GL, Gutierrez-Hartmann A 1994 Identification of the functional components of the Ras signaling pathway regulating pituitary cell-specific gene expression. Mol Cell Biol 14: 1553-1565
23. Theill LE, Hattori K, Domenico D, Castrlllo J-L, Karin M 1992 Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomaln proteins. EMBO J 11: 2261-2269
24. Theill LE, Castrillo JL, Wu D, Karin M 1989 Dissection of functional domains of the pituitary-specific transcription factor GHF-1. Nature 342: 945-948
25. Konzak KE, Moore DD 1992 Functional isoforms of Pit-1 generated by alternative mRNA splicing. Mol Endocrinol 6: 241-247
26. Ingraham HA, Chen RP, Mangalam HJ, Elsholtz, HP, Flynn SE, Un CR, Simmons DM, Swanson L, Rosenfeld MG 1988 A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell 55: 519-529
27. Morris AE, Kloss B, McChesney RE, Bancroft C, Chasin LA 1992 An alternatively spliced Pit-1 Isoform altered in its ability to trans-activate. Nucleic Acids Res 20: 1355-1361
28. Berwaer M, Peers B, Nalda AM, Monget P, Davis JRE, Belayew A, Martial JA 1993 Thyrotropin-releasing hormone and epidermal growth factor induce human prolactin expression via identical multiple cis elements. Mol Cell Endocrinol 92: 1-7
29. Coleman DT, Bancroft C 1993 Pituitary adenylate cyclaseactivating polypeptide stimulates prolactin gene expression in a rat pituitary cell line. Endocrinology 133: 2736-2742
30. Drolet DW, Scully KM, Simmons DM, Swanson LW, Wegner M, Chu K, Rosenfeld MG 1991 TEF, a transcription factor expressed in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev 5: 1739-1753
31. Keech CA, Gutierrez-Hartmann A 1991 Insulin activation of rat prolactin promoter activity. Mol Cell Endocrinol 78: 55-60
32. Haugen BR, Gordon DF, Nelson AR, Wood WW, Ridg-way EC 1994 The combination of Pit-1 and Pit-IT have a synergistic stimulatory effect on the thyrotropin β-sub-unit promoter but not the growth hormone or prolactin promoters. Mol Endocrinol 8: 1574-1582
33. Kapiloff MS, Farkash Y, Wegner M, Rosenfeld MG 1991 Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements. Science 253: 786-789
34. Dana S, Karin M 1989 Induction of human growth hormone promoter activity by the adenosine 3',5'-mono-phosphate pathway involves a novel response element. Mol Endocrinol 3: 815-821
35. Copp RP, Samuels HH 1989 Identification of an adenosine 3',5'-monophosphate (cAMP)-responsive region in the rat growth hormone gene: Evidence for independent and synergistic effects of cAMP and thyroid hormone on gene expression. Mol Endocrinol 3: 790-796
36. Oklmura Y, Howard PW, Maurer RA 1994 Plt-1 binding sites mediate transcriptional responses to cAMP through a mechanism which does not require inducible phosphorylation of Pit-1. Mol Endocrinol 8: 1559-1565
37. Fischberg DJ, Chen X-H, Bancroft C 1994 A Pit-1 phosphorylation mutant can mediate either basal or induced prolactin or growth hormone promoter activity. Mol Endocrinol 8: 1566-1573
38. Gutierrez-Hartmann A 1994 Pit-1/GHF-1: A pituitary-specific transcription factor linking general signaling pathways to cell-specific gene expression. Mol Endocrinol 8: 1447-1449
39. Voss JW, Wilson L, Rosenfeld MG 1991 POU-domaln proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to Induce exression of the prolactin promoter. Genes Dev 5: 1309-1320
40. Lipkln SM, Naar AM, Kalla KA, Sack RA, Rosenfeld MG 1993 Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression. Genes Dev 7: 1674-1687
41. Day RN, Koike S, Sakai M, Muramatsu M, Maurer RA 1990 Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene. Mol Endocrinol 4: 1964-1971
42. Schaufele F, West BL, Baxter JD 1992 Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor. Mol Endocrinol 6: 656-665
43. Oberwetter JM, Conrad KE, Gutierrez-Hartmann A 1993 The Ras and protein kinase C signaling pathways are functionally antagonistic in GH4 neuroendocrine cells. Mol Endocrinol 7: 915-923
44. Maxwell IH, Harrison GS, Wood WM, Maxwell F 1989 A DNA cassette containing a trimerized SV40 polyadenyl-ation signal which efficiently blocks spurious plasmid-initiated transcription. Biotechniques 7: 276-280
45. de Wet JR, Wood KV, DeLuca M, Helinski DR, Subramani S 1987 Firefly luciferase gene: Structure and expression in mammalian cells. Mol Cell Biol 7: 725-737
46. MacGregor GR, Caskey CT 1989 Construction of plasmids that express E. coli beta-galactosidase in mammalian cells. Nucleic Acids Res 17: 2365