Expression of the Gastrin-releasing Peptide Receptor Confers a Growth Response to Bombesin in Immortalized Human Bronchial Epithelial Cells

Cancer Research

Volumn 55, Issue 9, 1995, Pages 1853-1855

  Al Moustafa, Ala Eddin ^a   Viallet, Jean ^a   Tsao, Ming Sound ^a   Battey, James F ^b  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOMBESIN; GASTRIN RELEASING PEPTIDE;

ARTICLE; BINDING SITE; BRONCHUS MUCOSA; CELL GROWTH; DNA TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION;

ANIMAL; BLOTTING, NORTHERN; BOMBESIN; BRONCHI; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; EPITHELIUM; FEMALE; HUMAN; IODINE RADIOISOTOPES; KINETICS; MICE; MICE, NUDE; RECEPTORS, BOMBESIN; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TRANSFECTION;

EID: 0028898209     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Cuttitta, R., Carney, D. N., Mulshine, J., Moody, T. W., Fedorko, J., Fischler, A., and Minna, J. D. Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Nature (Lond.), 316: 823–826, 1985.
2. Corjay, M. H., Dobrzanski, D. J., Way, J. M., Viallet, J., Shapira, H., Worland, P., Sausville, E. A., and Battey, J. F. Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. J. Biol. Chem., 266: 18771–18779, 1991.
3. Fathi, Z., Corjay, M. H., Shapira, H., Wada, E., Benya, R., Jensen, R., Viallet, J., Sausville, E. A., and Battey, J. F. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. J. Biol. Chem., 268: 5979–5984, 1993.
4. Frankel, A., Tsao, M.-S., and Viallet, J. Receptor subtype expression and responsiveness to bombesin in cultured human bronchial epithelial cells. Cancer Res., 54: 1613–1616, 1994.
5. Viallet, J., Liu, C., Emond, J., and Tsao, M.-S. Characterization of human bronchial epithelial cells immortalized by the E6 and E7 genes of human papillomavirus type 16. Exp. Cell Res., 212: 36–41, 1994.
6. Scatchard, G. The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci., 57: 660–672, 1949.
7. Frankel, A., and Viallet, J. Protein kinase C is not involved in the homologous desensitization of bombesin responses in small cell lung cancer cells. Exp. Cell Res., 209: 398–401, 1993.
8. Walsh, J., Bouzyk, M., and Rozengurt, E. Homologous desensitization of bombesin-induced increases in intracellular Ca2+ in quiescent Swiss 3T3 cells involves a protein kinase C-independent mechanism. J. Cell. Physiol., 156: 333–340, 1993.
9. Jetten, A. M., Vollberg, T. M., and Nervi, C. Hyperplasia and squamous metaplasia in the tracheobronchial epithelium: alterations in the balance of growth and differentiation factors. Adv. Exp. Med. Biol., 320: 89–93, 1992.
10. Tsao, M.-S., Zhu, H., Giaid, A., Viallet, J., Nakamura, T., and Park, M. Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial cells and lung carcinoma cells. Cell Growth & Differ., 4: 571–579, 1993.
11. Viallet, J., and Minna, J. Gastrin-releasing peptide (GRP, mammalian bombesin) in the pathogenesis of lung cancer. Prog. Growth Factor Res., 1: 89–97, 1989.
12. Aguayo, S., Kane, M., King, T. J., Schwarz, M., Grauer, L., and Miller, Y. Increased levels of bombesin-like peptides in the lower respiratory tract of asymptomatic cigarette smokers. J. Clin. Invest., 84: 1105–1113, 1989.
13. Willey, J. C., Lechner, J. F., and Harris, C. C. Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells. Exp. Cell Res., 153: 245–248, 1984.
14. Siegfried, J. S., Guentert, P. J., and Gaither, A. L. Effects of bombesin and gastrin-releasing peptide on human bronchial epithelial cells from a series of donors: individual variation and modulation by bombesin analogs. Anat. Rec., 236: 2A1–2A7, 1993.
15. Lundgren, J., Baraniuk, J., Ostrowski, N., Kaliner, M., and Shelhamer, J. Gastrin-releasing peptide stimulates glycoconjugate release from feline trachea. Am. J. Physiol., 258: L68-L74, 1990.
16. Baraniuk, J. N., Lundgren, J. D., Shelhamer, J. H., and Kaliner, M. A. Gastrin releasing peptide (GRP) binding sites in human bronchi. Neuropeptides, 21: 81–84, 1992.
17. Zachary, I., and Rozengurt, E. Focal adhesion kinase (pl25FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes. Cell, 71: 891–894, 1992.