Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

Cell

Volumn 80, Issue 3, 1995, Pages 485-496

  Kennedy, Brian K ^a   Austriaco Jr , Nicanor R ^a   Zhang, Jisi ^a   Guarente, Leonard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ARTICLE; CONTROLLED STUDY; GENE LOCUS; GENE MUTATION; GENE REPRESSION; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TELOMERE;

SACCHAROMYCES CEREVISIAE;

EID: 0028897013     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90499-9     Document Type: Article

References (65)

1. Telomere length predicts replicative capacity of human fibroblasts
2. Modifiers of position effect are shared between Teomere and silent mating-type loci in Saccharomyces cerevisiae
3. Elevated paraquat resistance can be used as a bioassay for longevity in a genetically based long-lived strain of Drosophila
4. 5-Fluororotic acid as a selective agent in yeast molecular genetics
5. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
6. Organization of DNA sequences and replication origins at yeast telomeres
7. Identification of a Ty1 regulatory sequence responsive to STE7 and STE12
8. Telomere length constancy during aging of Saccharomyces cerevisiae
9. Preparation and partial characterization of old yeast cells
10. Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae
11. Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene
12. Replicative senescence: the human fibroblast comes of age
13. On the nature of the function expressive of the law of human mortality and on the mode of determining the value of life contingencies
14. Genetic linkage of Werner's syndrome to five markers on chromosome 8
15. Characterization of the cell cycle of cultured human diploid cells: effects of aging and hydrocortisone
16. Heme regulates transcription of the CYCI gene of S. cerevisiae via an upstream activation site
17. Telomeres shorten during ageing of human fibroblasts
18. Mutants of S. cerevisiae unresponsive to cell division control by polypeptide mating hormones
19. The limited in vitro lifetime of human diploid cell strains
20. A gene involved in control of human cellular senescence on human chromosome 1q
21. Putting the HO gene to work: practical uses for mating-type switching
22. Cloning and characterization of four SIR genes of Saccharomyces cerevisiae
23. Replication control and cellular life span
24. The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression
25. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging
26. Reproductive capacity and mode of death of yeast cells
27. A C. elegans mutant that lives twice as long as wild type
28. Daughter cells of S. cerevisiae from old mothers display a reduced life span
29. An ancient developmental induction: heat-shock proteins induced in sporulation and oogenesis
30. Silencers, silencing, and heritable transcriptional states
31. Selection for delayed senescence in Drosophila melanogaster
32. Gene action in the X-chromosome of the mouse (Mus musculus L.)
33. The HML mating-type cassette of Saccharomyces cerevisiae is regulated by two separate but functionally equivalent silencers
34. Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae
35. Life span of individual yeast cells
36. Experiments on ageing in single cells of Saccharomyces cerevisiae
37. Parental age and the life span of zygotes of Saccharomyces cerevisiae
38. Calender life span versus budding life span of Saccharomyces cerevisiae
39. Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on chromosome 4
40. Dominance of the senescent phenotype in heterokaryons between replicative and post-replicative human fibroblast-like cells
41. A theory of marginotomy
42. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres
43. Genetic analysis of indefinite division in human cells. Identification of four complementation groups
44. Epigenetic inheritance of transcriptional states in S. cerevisiae
45. Induction of heat shock proteins and thermotolerance by ethanol in Saccharomyces cerevisiae
46. A formal mortality analysis for populations of unicellular organisms
47. Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage
48. Physical maps of the six smallest chromosomes of Saccharomyces cerevisiae at a resolution of 2.6 kilobase pairs
49. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
50. Genetics of life-history of Drosophila melanogaster
51. Evidence of clonal attenuation, clonal succession, and clonal expansion in mass cultures of aging Werners syndrome skin fibroblasts
52. Telomere reduction in giant cell tumor of bone and with aging
53. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis
54. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
55. Induction of cellular senescence in immortalized cells by human chromosome I
56. A multi-subunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
57. Production of sperm reduces nematode lifespan
58. Loss of telomeric DNA during aging of normal and Trisomy 21 human lymphocytes
59. Genetic analysis of chemosensory control of Dauer formation in Caenorhabditis elegans
60. Unusual DNA sequences associated with the ends of yeast chromosomes
61. Age related reactivation of an X-linked gene
62. The STE4 and STE18 genes of yeast encode potential δ and γ subunits of the mating factor receptor-coupled G protein
63. DNA methylation decreases in aging but not in immortal cells