Prodigiosin 25-C uncouples vacuolar type H+-ATPase, inhibits vacuolar acidification and affects glycoprotein processing

FEBS Letters

Volumn 359, Issue 1, 1995, Pages 53-59

  Kataoka, Takao ^a   Muroi, Makoto ^b   Ohkuma, Shoji ^c   Waritani, Takaki ^c   Magae, Junji ^a   Takatsuki, Akira ^b   Kondo, Shunzo ^d   Yamasaki, Makari ^e   Nagai, Kazuo ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

^d MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

Acidification; Glycoprotein processing; Prodigiosin 25 C; Vacuolar type H+ ATPase

Indexed keywords

3 AMINO 3' (2,4 DINITROANILINO) N METHYLDIPROPYLAMINE; ACRIDINE ORANGE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CONCANAMYCIN A; MONENSIN; OLIGOMYCIN; PRODIGIOSIN; PRODIGIOSIN 25C; PROTON PUMP; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ACIDIFICATION; ANIMAL TISSUE; ARTICLE; CELL PH; CELL STRAIN BHK; CONTROLLED STUDY; CYTOCHEMISTRY; ENZYME ACTIVITY; GOLGI COMPLEX; LIVER LYSOSOME; MITOCHONDRION; MORPHOLOGY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; STREPTOMYCES; TRANSMISSION ELECTRON MICROSCOPY; VESICULAR STOMATITIS VIRUS;

ADENOSINE TRIPHOSPHATE; ANIMAL; CELL LINE; GLYCOPROTEINS; GOLGI APPARATUS; HAMSTERS; HYDROGEN-ION CONCENTRATION; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; LIVER; LYSOSOMES; MALE; MICROSCOPY, ELECTRON; MITOCHONDRIAL SWELLING; PRODIGIOSIN; PROTON PUMPS; PROTON-TRANSLOCATING ATPASES; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; VACUOLES;

ANIMALIA; CRICETINAE; STREPTOMYCES; VESICULAR STOMATITIS VIRUS;

EID: 0028896647     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(94)01446-8     Document Type: Article

References (32)

1. Folimycin (concanamycin A) and Bafilomycin A1, Inhibitors Specific for V-ATPase, Exert Similar but Distinct Effects on Intracellular Translocation and Processing of Glycoproteins
2. Prodigiosin-25 C Isolation and the Chemical Structure