Abnormal Patterns of D-Type Cyclin Expression and G1 Regulation in Human Head and Neck Cancer

Cancer Research

Volumn 55, Issue 4, 1995, Pages 949-956

  Bartkova, Jirina ^a   Lukas, Jiri ^a   Müller, Heiko ^a   Strauss, Michael ^a,b   Gusterson, Barry ^c   Bartek, Jiri ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE;

ARTICLE; CARCINOGENESIS; CELL CYCLE G1 PHASE; CONTROLLED STUDY; GENE AMPLIFICATION; GENE EXPRESSION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN DETERMINATION;

CARCINOMA, SQUAMOUS CELL; CYCLIN D1; CYCLINS; G1 PHASE; HEAD AND NECK NEOPLASMS; HUMAN; IMMUNOHISTOCHEMISTRY; ONCOGENE PROTEINS; PARAFFIN EMBEDDING; SUPPORT, NON-U.S. GOV'T;

EID: 0028894280     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Renan, M. J. How many mutations are required for tumorigenesis? Implications from human cancer data. Mol. Carcinog., 7: 139–146, 1993.
2. Nawroz, H., van der Riet, P., Hruban, R. H., Koch, W., Ruppert, J. M., and Sidransky, D. Allelotype of head and neck squamous cell carcinoma. Cancer Res., 54: 1152–1155, 1994.
3. Gusterson, B. A., Anbazhagan, R., Warren, W., Midgley, C. A., Lane, D. P., O'Hare, M., Stamps, A., Carter, R., and Jayatilake, H. Expression of p53 in premalignant and malignant squamous epithelium. Oncogene, 6: 1785–1789, 1991.
4. Brachman, D. G., Graves, D., Vokes, E., Beckett, M., Haraf, D., Montag, A., Dunphy, E., Mick, R., Yandell, D., and Wechselbaum, R. R. Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer. Cancer Res., 52: 4832–4836, 1992.
5. Somers, K., Merrick, M. E., Lopez, M. E., Incognito, L. S., Schechter, G. L., and Casey, G. Frequent p53 mutations in head and neck cancer. Cancer Res., 52: 5997–6000, 1992.
6. Boyle, J. O., Hakim, J., Koch, W., van der Riet, P., Hruban, R. H., Roa, A., Correo, R., Eby, Y. J., Ruppert, J. M., and Sidransky, D. The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res., 53: 4477–4480, 1993.
7. Serrano, M., Hannon, G. J., and Beach, D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/cdk4. Nature (Lond.), 366: 704–707, 1993.
8. Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stocken, E., Day, R. S., Johnson, B. E., and Skolnick, M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science (Washington DC), 264: 436–440, 1994.
9. Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashi, K., and Carson, D. A. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond.), 368: 753–756, 1994.
10. Marx, J. A challenge to pl6 gene as a major tumor suppressor. Science (Washington DC), 264: 1846, 1994.
11. Berenson, J. R., Yang, J., and Mickel, R. A. Frequent amplification of the bcl-1 locus in head and neck squamous cell carcinomas. Oncogene, 4: 1111–1116, 1989.
12. Somers, K. D., Cartwright, S. L., and Schechter, G. L. Amplification of the int-2 gene in human head and neck squamous cell carcinomas. Oncogene, 5: 915–920, 1990.
13. Lammie, G., Fantl, V., Smith, R., Schuuring, E., Brookes, S., Michalides, R., Dickson, C., Arnold, A., and Peters, G. D11S287, a putative oncogene on chromosome llql3, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1. Oncogene, 6: 439–444, 1991.
14. Schuuring, E., Verhoeven, E., Mooi, W. J., and Michalides, R. J. A. M. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11ql3 region in human carcinomas. Oncogene, 7: 355–361, 1992.
15. Motokura, T., and Arnold, A. Cyclins and oncogenesis. Biochim. Biophys. Acta, 1155: 63–78, 1993.
16. Lew, D. J., Dulic, V., and Reed, S. I. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell, 66: 1197–1206, 1991.
17. Matsushime, H., Roussel, M. F., Ashmun, R. A., and Sherr, C. J. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell, 65: 701–713, 1991.
18. Xiong, Y., Connolly, T., Futcher, B., and Beach, D. Human D-type cyclin. Cell, 65: 691–699, 1991.
19. Motokura, T., Bloom, T., Kim, H. G., Juppner, H., Ruderman, J. V., Kronenberg, H. M., and Arnold, A. A novel cyclin encoded by a bell-linked candidate oncogene. Nature (Lond.), 350: 512–515, 1991.
20. Sherr, C. J. Mammalian G1 cyclins. Cell, 73: 1059–1065, 1993.
21. Lukas, J., Pagano, M., Staskova, Z., Draetta, G., and Bartek, J. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene, 9: 707–718, 1994.
22. Bartkova, J., Lukas, J., Strauss, M., and Bartek, J. Cell cycle-related variation and tissue-restricted expression of cyclin D1 protein. J. Pathol., 172: 237–245, 1994.
23. Baldin, V., Lukas, J., Marcote, M. J., Pagano, M., and Draetta, G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev., 7: 812–821, 1993.
24. Bartek, J., Vojtesek, B., Grand, R. J. A., Gallimore, P. H., and Lane, D. P. Cellular localization and T antigen binding of the retinoblastoma protein. Oncogene, 7: 101–108, 1992.
25. Gillett, C., Fantl, V., Smith, R., Fisher, C., Bartek, J., Dickson, C., Barnes, D., and Peters, G. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res., 54: 1812–1817, 1994.
26. Bartkova, J., Lukas, J., Müller, H., Lutzhøft, D., Strauss, M., and Bartek, J. Cyclin D1 protein expression and function in human breast cancer. Int. J. Cancer, 57: 353–361, 1994.
27. Zhang, Y-J., Jiang, W., Chen, C. J., Lee, G S., Kahn, S. M., Santella, R. M., and Weinstein, I. B. Amplification and overexpression of cyclin D1 in human hepatocellular Carcinoma. Biochem. Biophys. Res. Commun., 196: 1010–1016, 1993.
28. Müller, H., Lukas, J., Schneider, A., Warthoe, P., Bartek, J., Eilers, M., and Strauss, M. Cyclin D1 expression is regulated by the retinoblastoma protein. Proc. Natl. Acad. Sci. USA, 91: 2945–2949, 1994.
29. Lukas, J., Bartek, J., and Strauss, M. J. Efficient transfer of antibodies into mammalian cells by electroporation. J. Immunol. Methods, 170: 255–259, 1994.
30. Lukas, J., Jadayel, D., Bartkova, J., Nacheva, E., Dyer, M. J. S., Strauss, M., and Bartek, J. BCL-1/cyclin D1 oncoprotein oscillates and subverts the G1 phase control in B-cell neoplasms carrying the t(ll;14) translocation. Oncogene, 9: 2159–2167, 1994.
31. Motokura, T., Keyomarsi, K., Kronenberg, H. M., and Arnold, A. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRADl/cyclin D1 proto-oncogene. J. Biol. Chem., 267: 20412–20415, 1992.
32. Lukas, J., Müller, H., Bartkova, J., Spitkovsky, D., Kjerulff, A. A., Jansen-Dürr, P., Strauss, M., and Bartek, J. DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J. Cell Biol., 125: 625–638, 1994.
33. Jiang, W., Zhang, Y-J., Kahn, S. M., Hollstein, M. C., Santella, R. M., Lu, S-H., Harris, C. C., Montesano, R., and Weinstein, I. B. Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc. Natl. Acad. Sci. USA, 90: 9026–9030, 1993.
34. Wang, T. C., Cardiff, R. D., Zukerberg, L., Lees, E., Arnold, A., and Schmidt, E. V. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature (Lond.), 369: 669–671, 1994.
35. Williams, B. O., Remington, L., Albert, D. M., Mukai, S., Branson, R. T., and Jacks, T. Cooperative tumorigenic effects of gennline mutations in Rb and p53. Nature Genet., 7: 480–484, 1994.
36. Quelle, D. E., Ashmun, R. A., Shurtleff, S. A., Kato, J-Y., Bar-Sagi, D., Roussel, M. F., and Sherr., C. J. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev., 7: 1559–1571, 1993.
37. Inaba, T., Matsushime, H., Valentine, M., Roussel, M. F., Sherr, C. J., and Look, A. T. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics, 13: 565–574, 1992.
38. Palmero, I., Holder, A., Sinclair, A., Dickson, C., and Peters, G. Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines. Oncogene, 8: 1049–1054, 1993.
39. Ando, K., Ajchenbaum-Cymbalista, F., and Griffin, J. D. Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells. Proc. Natl. Acad. Sci. USA, 90: 9571–9575, 1993.
40. Kato, J-Y., and Sherr, C. J. Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1. Proc. Natl. Acad. Sci. USA, 90: 11513–11517, 1993.
41. Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J-Y., and Livingston, D. M. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell, 73: 487–497, 1993.
42. Dowdy, S. F., Hinds, P. W., Louie, K., Reed, S. I., Arnold, A., and Weinberg, R. A. Physical interaction of the retinoblastoma protein with human D cyclins. Cell, 73: 499–511, 1993.
43. PSKJ3/cdk4) for mammalian D type G1 cyclins. Cell, 71: 323–334, 1992.
44. Kato, J-Y., Matsushime, H., Hieben, S. W., Ewen, M. E., and Sherr, C. J. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev., 7: 331–342, 1993.
45. Xiong, Y., Zhang, H., and Beach, D. D-type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell, 71: 505–514, 1992.
46. Xiong, Y., Menninger, J., Beach, D., and Ward, D. C. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics, 13: 575–584, 1992.
47. Bates, S., Bonetta, L., MacAllan, D., Parry, D., Holder, A., Dickson, C., and Peters, G. CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene, 9: 71–79, 1994.
48. Meyerson, M., and Harlow, E. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol., 14: 2077–2086, 1994.
49. Hinds, P. W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S. I., and Weinberg, R. A. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell, 70: 993–1006, 1992.
50. Matsushime, H., Quelle, D. E., Shurtleff, S. A., Shibuya, M., Sherr, C. J., and Kato, J-Y. D-type Cyclin-dependent kinase activity in mammalian cells. Mol. Cel. Biol., 14: 2066–2076, 1994.
51. Goodrich, D. W., and Lee, W-H. Molecular characterization of the retinoblastoma susceptibility gene. Biochim. Biophys. Acta, 1155: 43–61, 1993.
52. Bates, S., Parry, D., Bonetta, L., Vousden, K., Dickson, C., and Peters, G. Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene, 9: 1633–1640, 1994.
53. Schauer, I. E., Siriwardana, S., Langan, T. A., and Sclafani, R. A. Cyclin D1 overexpression vs. retinoblastoma inactivation: Implications for growth control evasion in non-small cell and small cell lung cancer. Proc. Natl. Acad. Sci. USA, 91: 7827–7831, 1994.
54. Dyson, N., Howley, P. M., Munger, K., and Harlow, E. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (Washington DC), 243: 934–937, 1989.
55. Rosenberg, C. L., Wong, E., Petty, E. M., Bale, A. E., Tsujimoto, Y., Harris, N. L., and Arnold, A. PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma. Proc. Natl. Acad. Sci. USA, 88: 9638–9642, 1991.
56. Withers, D., Harvey, R., Faust, J., Melnyk, O., Carey, K., and Meeker, T. Characterization of a candidate bell gene. Mol. Cell. Biol., 11: 4846–4853, 1991.
57. Seto, M., Yamamoto, K., Iida, S., et al Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(ll;14)(ql3↓2) translocation. Oncogene, 7: 1401–1406, 1992.
58. Jiang, W., Kahn, S. M., Tomita, N., Zhang, Y.-J., Lu, S.-H., and Weinstein, I. B. Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res., 52: 2980–2983, 1992.
59. Buckley, M. F., Kimberley, J. E., Sweeney, J. E., Hamilton, J. A., Sini, R. L., Manning, D. L., Nicholson, R. I., deFazio, A., Watts, C. K. W., Musgrove, E. A., and Sutherland, R. L. Expression and amplification of cyclin genes in human breast cancer. Oncogene, 8: 2127–2133, 1993.
60. Lebwohl, D. E., Muise-Helmericks, R., Sepp-Lorenzino, L., Serve, S., Timaul, M., Bol, R., Borgen, P., and Rosen, N. A truncated cyclin D1 gene encodes a stable mRNA in a human breast cancer cell line. Oncogene, 9: 1925–1929, 1994.
61. Jiang, W., Kahn, S. M., Zhou, P., Zhang, Y-J., Cacace, A. M., Infante, A. S., Doi, S., Santella, R. M., and Weinstein, I. B. Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene, 8: 3447–3457, 1993.
62. Lovec, H., Sewing, A., Lucibello, F. C., Müller, R., and Möröy, T. Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation. Oncogene, 9: 323–326, 1994.
63. Hinds, P. W., Dowdy, S. F., Eaton, E. N., Arnold, A., and Weinberg, R. A. Function of a human cyclin gene as an oncogene. Proc. Natl. Acad. Sci. USA, 91: 709–713, 1994.
64. Bodrug, S. E., Warner, B. J., Bath, M. L., Lindeman, G. J., Harris, A. W., and Adams, J. M. Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO J., 13: 2124–2130, 1994.
65. Lovec, H., Grzeschiczek, A., Kowalski, M-B., and Möröy, T. Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice. EMBO J., 13: 3487–3495, 1994.
66. Hanna, Z., Jankowski, M., Tremblay, P., Jiang, X., Milatovich, A., Francke, U., and Joliceur, P. The Vin-1 gene, identified by provirus insertional mutagenesis, is the cyclin D2. Oncogene, 8: 1661–1666, 1993.
67. Leach, F. S., Elledge, S. J., Sherr, C. J., Willson, J. K. V., Markowitz, S., Kinzler, K. W., and Vogelstein, B. Amplification of cyclin genes in colorectal carcinomas. Cancer Res., 53: 1986–1989, 1993.